HK1016090A1 - Bradykinin analogs as selective thrombin inhibitors - Google Patents

Bradykinin analogs as selective thrombin inhibitors

Info

Publication number
HK1016090A1
HK1016090A1 HK99101383A HK99101383A HK1016090A1 HK 1016090 A1 HK1016090 A1 HK 1016090A1 HK 99101383 A HK99101383 A HK 99101383A HK 99101383 A HK99101383 A HK 99101383A HK 1016090 A1 HK1016090 A1 HK 1016090A1
Authority
HK
Hong Kong
Prior art keywords
bradykinin
induced
pct
thrombin
analogs
Prior art date
Application number
HK99101383A
Other languages
English (en)
Inventor
Alvin H Schmaier
Ahmed A K Hasan
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of HK1016090A1 publication Critical patent/HK1016090A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK99101383A 1995-06-09 1999-04-07 Bradykinin analogs as selective thrombin inhibitors HK1016090A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9695P 1995-06-09 1995-06-09
PCT/US1996/009940 WO1996041640A1 (fr) 1995-06-09 1996-06-07 Analogues de la bradykinine utilises comme inhibiteurs selectifs de la thrombine

Publications (1)

Publication Number Publication Date
HK1016090A1 true HK1016090A1 (en) 1999-10-29

Family

ID=21689904

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99101383A HK1016090A1 (en) 1995-06-09 1999-04-07 Bradykinin analogs as selective thrombin inhibitors

Country Status (9)

Country Link
US (1) US6143719A (fr)
EP (1) EP0871464B1 (fr)
JP (1) JP4067117B2 (fr)
AT (1) ATE235912T1 (fr)
AU (1) AU703256B2 (fr)
CA (1) CA2221865C (fr)
DE (1) DE69627191T2 (fr)
HK (1) HK1016090A1 (fr)
WO (1) WO1996041640A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20020076782A1 (en) * 1996-07-05 2002-06-20 John P.N. Rosazza Purified nitric oxide synthase
WO1998047522A1 (fr) * 1997-04-23 1998-10-29 The Regents Of The University Of Michigan Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire
AU761624B2 (en) * 1997-04-23 2003-06-05 Regents Of The University Of Michigan, The Bradykinin analogs as selective inhibitors of cell activation
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
US6767889B1 (en) 1998-11-10 2004-07-27 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
ATE324901T1 (de) 1998-11-10 2006-06-15 Univ Temple Hemmung der angiogenese durch peptidanaloge der kininogen domäne 5mit hohem molekulargewicht
AU774694B2 (en) * 1998-12-16 2004-07-01 Temple University - Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
US6869931B1 (en) * 1998-12-16 2005-03-22 Temple University - Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
US6544750B1 (en) * 1999-08-17 2003-04-08 Thromgen, Inc. Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US6994852B1 (en) 1999-11-12 2006-02-07 Temple University-Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
US7074765B2 (en) * 2003-05-01 2006-07-11 The Regents Of The University Of Michigan Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
EP1778652A2 (fr) * 2004-08-20 2007-05-02 EntreMed, Inc. Compositions et procedes comportant des antagonistes de recepteur active par la proteinase
WO2006045503A1 (fr) 2004-10-19 2006-05-04 Lonza Ag Procede de synthese de peptides en phase solide
US7879792B2 (en) * 2005-06-02 2011-02-01 The Regents Of The University Of Michigan Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
CA2818522C (fr) 2010-12-02 2016-05-17 Becton, Dickinson And Company Dispositifs de prelevement sanguin contenant un agent de stabilisation du sang

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4693993A (en) * 1985-06-13 1987-09-15 Stewart John M Bradykinin antagonist peptides
US4870017A (en) * 1985-09-20 1989-09-26 Cetus Corporation Bacterial methionine N-terminal peptidase
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US5416191A (en) * 1991-04-01 1995-05-16 Cortech, Inc. Bradykinin antagonists
HUT65328A (en) * 1991-04-01 1994-05-02 Cortech Process for producing bradykinin antagonists
DE69231918D1 (de) * 1991-04-19 2001-08-09 Scios Nova Inc Peptidantagonisten des bradykinin
AU2548992A (en) * 1991-08-13 1993-03-16 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
FR2686343B1 (fr) * 1992-01-17 1994-03-11 Adir Cie Nouveaux derives pseudopeptidiques a activite antagoniste de la bradykinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH07507995A (ja) * 1992-03-02 1995-09-07 バイオジェン，インコーポレイテッド トロンビンレセプターアンタゴニスト
IL107400A0 (en) * 1992-11-10 1994-01-25 Cortech Inc Bradykinin antagonists

Also Published As

Publication number Publication date
ATE235912T1 (de) 2003-04-15
JP4067117B2 (ja) 2008-03-26
DE69627191D1 (de) 2003-05-08
AU703256B2 (en) 1999-03-25
DE69627191T2 (de) 2004-01-08
CA2221865A1 (fr) 1996-12-27
EP0871464B1 (fr) 2003-04-02
CA2221865C (fr) 2007-12-11
AU6382896A (en) 1997-01-09
WO1996041640A1 (fr) 1996-12-27
EP0871464A4 (fr) 2001-05-16
EP0871464A1 (fr) 1998-10-21
JP2001511762A (ja) 2001-08-14
US6143719A (en) 2000-11-07

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100607