ES2003112A6 - Un procedimiento para la preparacion de un decapeptido. - Google Patents

Un procedimiento para la preparacion de un decapeptido.

Info

Publication number
ES2003112A6
ES2003112A6 ES8602274A ES8602274A ES2003112A6 ES 2003112 A6 ES2003112 A6 ES 2003112A6 ES 8602274 A ES8602274 A ES 8602274A ES 8602274 A ES8602274 A ES 8602274A ES 2003112 A6 ES2003112 A6 ES 2003112A6
Authority
ES
Spain
Prior art keywords
neurokinin
solutions containing
peptide antagonists
opthalmic solutions
decapeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602274A
Other languages
English (en)
Inventor
David Erick Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho McNeil Pharmaceutical Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES2003112A6 publication Critical patent/ES2003112A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

EL DECAPEPTIDO DE FORMULA (I): A1-D-PRO2-HIS3-D4-PHE5-D-TRP6-VAL7-D-TRP8-LEU9-NLE10-NH2FF(I) DONDE A1 ES ASP1 O D-ASP1 Y D4 ES ASP4 O D)ASP4 Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, SE OBTIENE HACIENDO REACCIONAR JUNTOS Y EN CUALQUIER ORDEN QUE SE DESEE LOS AMINOACIDOS INDIVIDUALES 1 A 10 ANTES SEÑALADOS. ESTOS DECAPEPTIDOS SON ANALGESICOS Y EJERCEN ACTIVIDAD ANTAGONISTA DE LA NEUROQUININA B QUE TAMBIEN ES CONOCIDA COMO NEUROMEDINA K. DICHOS DECAPEPTIDOS SON UTILES PARA LA OBTENCION DE SOLUCIONES OFTALMICAS PARA EL TRATAMIENTO DEL DOLOR O LA INFLAMACION.
ES8602274A 1985-09-30 1986-09-29 Un procedimiento para la preparacion de un decapeptido. Expired ES2003112A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/781,839 US4665157A (en) 1985-09-30 1985-09-30 Peptide antagonists of neurokinin B

Publications (1)

Publication Number Publication Date
ES2003112A6 true ES2003112A6 (es) 1988-10-16

Family

ID=25124115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602274A Expired ES2003112A6 (es) 1985-09-30 1986-09-29 Un procedimiento para la preparacion de un decapeptido.

Country Status (9)

Country Link
US (1) US4665157A (es)
EP (1) EP0219258A3 (es)
JP (1) JPS62123198A (es)
AU (1) AU587285B2 (es)
CA (1) CA1291592C (es)
DK (1) DK464986A (es)
ES (1) ES2003112A6 (es)
GR (1) GR862451B (es)
ZA (1) ZA867423B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742156A (en) * 1985-09-30 1988-05-03 Mcneilab, Inc. Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4665157A (en) * 1985-09-30 1987-05-12 Mcneilab, Inc. Peptide antagonists of neurokinin B
US5331089A (en) * 1988-03-25 1994-07-19 Merck Sharpe & Dohme, Ltd. Peptides useful as tachykinin agonists
DE3813124A1 (de) * 1988-04-15 1989-10-26 Krieg Benno Destillierbare pufferloesungen und ihre anwendungen
US6218364B1 (en) 1988-06-20 2001-04-17 Scott L. Harbeson Fluorinated neurokinin A antagonists
US5830863A (en) * 1988-06-20 1998-11-03 Merrell Pharmaceuticals Inc. Neurokinin A antagonists
IT1233696B (it) * 1989-05-29 1992-04-14 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione
ZA906188B (en) * 1989-08-10 1991-06-26 Merrell Dow Pharma Cyclic neurokinin a antagonists
US5374621A (en) * 1991-09-13 1994-12-20 Regents Of The University Of California Neurotensin method for inhibiting vascular leakage
US5328927A (en) * 1992-03-03 1994-07-12 Merck Sharpe & Dohme, Ltd. Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
GB9927125D0 (en) 1999-11-16 2000-01-12 Univ Reading The Placental human neurokinin B precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4481139A (en) * 1983-04-13 1984-11-06 Board Of Regents, The University Of Texas System Peptide antagonists of substance P
US4665157A (en) * 1985-09-30 1987-05-12 Mcneilab, Inc. Peptide antagonists of neurokinin B

Also Published As

Publication number Publication date
DK464986D0 (da) 1986-09-29
ZA867423B (en) 1988-04-27
GR862451B (en) 1987-02-03
JPS62123198A (ja) 1987-06-04
CA1291592C (en) 1991-10-29
EP0219258A2 (en) 1987-04-22
AU587285B2 (en) 1989-08-10
DK464986A (da) 1987-03-31
EP0219258A3 (en) 1988-12-21
AU6321486A (en) 1987-04-02
US4665157A (en) 1987-05-12

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