WO1989001490A3 - Molecules biologiquement actives - Google Patents

Molecules biologiquement actives Download PDF

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Publication number
WO1989001490A3
WO1989001490A3 PCT/GB1988/000668 GB8800668W WO8901490A3 WO 1989001490 A3 WO1989001490 A3 WO 1989001490A3 GB 8800668 W GB8800668 W GB 8800668W WO 8901490 A3 WO8901490 A3 WO 8901490A3
Authority
WO
WIPO (PCT)
Prior art keywords
positions
peptide
biologically active
salts
active molecules
Prior art date
Application number
PCT/GB1988/000668
Other languages
English (en)
Other versions
WO1989001490A2 (fr
Inventor
Stephen James
John Hamilton Riley
Robert Bomford
Original Assignee
Coopers Animal Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coopers Animal Health filed Critical Coopers Animal Health
Priority to KR1019890700618A priority Critical patent/KR890701621A/ko
Priority to BR888807658A priority patent/BR8807658A/pt
Publication of WO1989001490A2 publication Critical patent/WO1989001490A2/fr
Publication of WO1989001490A3 publication Critical patent/WO1989001490A3/fr
Priority to DK034590A priority patent/DK34590A/da
Priority to LVP-93-543A priority patent/LV10627B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention se rapporte à un peptide présentant une homologie structurale primaire avec une séquence continue de résidus d'acides aminés de l'hormone de la croissance bovine dans les positions d'occupation de régions 1 à 18 ou 55 à 72 ou 97 à 110 ou 122 à 138, à des peptides antigéniquement équivalents à un tel peptide ou à des sels d'un tel peptide. Ledit peptide est de préférence choisi parmi les peptides suivants: (a) 122-138; (b) 119-131; (c) 130-143; (d) 123-137; (e) 133-146; chacun desdits peptides peut être d'origine bovine, ovine, porcine, avienne ou provenir de salmonidés ou peut constituer des sels de n'importe lesquels de ces peptides. Ledit peptide peut être administré à des vertébrés dans des formulations antigéniques destinées à améliorer la croissance ou (chez les mammifères) la lactation.
PCT/GB1988/000668 1987-08-11 1988-08-11 Molecules biologiquement actives WO1989001490A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019890700618A KR890701621A (ko) 1987-08-11 1988-08-11 생물학적 활성분자
BR888807658A BR8807658A (pt) 1987-08-11 1988-08-11 Peptideos tendo homologia estrutural, formulacao antigena farmaceutica e processo para alterar as caracteristicas de um vertebrado
DK034590A DK34590A (da) 1987-08-11 1990-02-09 Biologisk aktive molekyler
LVP-93-543A LV10627B (en) 1987-08-11 1993-06-09 Biologically active peptide molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8718937 1987-08-11
GB878718937A GB8718937D0 (en) 1987-08-11 1987-08-11 Biologically active molecules

Publications (2)

Publication Number Publication Date
WO1989001490A2 WO1989001490A2 (fr) 1989-02-23
WO1989001490A3 true WO1989001490A3 (fr) 1989-04-06

Family

ID=10622096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1988/000668 WO1989001490A2 (fr) 1987-08-11 1988-08-11 Molecules biologiquement actives

Country Status (19)

Country Link
EP (1) EP0303488B1 (fr)
JP (1) JPH02504632A (fr)
KR (1) KR890701621A (fr)
AT (1) ATE116333T1 (fr)
AU (1) AU629179B2 (fr)
BR (1) BR8807658A (fr)
DE (1) DE3852588T2 (fr)
DK (1) DK34590A (fr)
ES (1) ES2066787T3 (fr)
GB (1) GB8718937D0 (fr)
GR (1) GR3015288T3 (fr)
HU (2) HUT52788A (fr)
IE (1) IE67318B1 (fr)
LV (1) LV10627B (fr)
MY (1) MY103759A (fr)
NZ (1) NZ225767A (fr)
PT (1) PT88229B (fr)
WO (1) WO1989001490A2 (fr)
ZA (1) ZA885892B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0556171T3 (da) * 1989-10-12 2000-12-18 Univ Ohio Væksthormon-antagonister
US5210180A (en) * 1989-10-27 1993-05-11 American Cyanamid Company Enhancement of porcine somatotropin activity
US6165465A (en) * 1990-05-15 2000-12-26 American Cyanamid Company Immunologic enhancement of the somatogenic effect of somatotropin with an antibody
CA2143739A1 (fr) * 1992-09-07 1994-03-17 Andrew T. Holder Molecules augmentant l'effet de l'hormone de croissance
FR2744123B1 (fr) * 1996-01-26 1998-04-17 Carelli Claude Marcel Henri Molecules biologiquement actives plus particulierement peptidiques ayant un effet potentialisateur de l'activite biologique de l'hormone de croissance
FR2833012B1 (fr) * 2001-12-04 2004-01-30 Centre Nat Rech Scient Peptides agonistes de l'hormone de croissance et leurs applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004915A1 (fr) * 1983-06-04 1984-12-20 Amgen Peptides biologiquement actifs apparentes structuralement a des regions dans des hormones de croissance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004915A1 (fr) * 1983-06-04 1984-12-20 Amgen Peptides biologiquement actifs apparentes structuralement a des regions dans des hormones de croissance

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemistry, volume 27, 1988, P.R. Gooley et al.: "Determination of local conformational stability in fragment 96-133 of bovine growth hormone by high-resolution 1H NMR spectroscopy", pages 802-809 *
Chemical Abstracts, volume 100, 1984, (Columbus, Ohio, US), W.P. VanderLaan et al.: "Study of human growth hormone structure with a radioimmunoassay specific for the fifteen amino acid fragment comprising hGH (32-46)", see page 71 *
Chemical Abstracts, volume 106, 1987, (Columbus, Ohio, US), R.W. Stevenson et al.: "The synthetic 32-46 fragment of human growth hormone increases insulin and glucagon levels in the conscious dog", see page 99 *
Chemical Abstracts, volume 108, 1988 (Columbus, Ohio, US), D.N. Brems et al.: "A search for ordered secondary structure in isolated fragments of bovine growth hormone", see page 82 *
Chemical Abstracts, volume 109, 1988, (Columbus, Ohio, US), P.R. Gooley et al.: "The preferred conformational state of the N-terminus section of a bovine growth hormone fragment (residues 96-133) in water is an omega loop", see page 92 *
J. Org. Chem., volume 40, no. 9, 1975, S.-S. Wang et al.: "Preparation of protected peptide intermediates for a synthesis of the ovine pituitary growth hormone sequence 96-135", pages 1227-1234 *

Also Published As

Publication number Publication date
LV10627A (lv) 1995-04-20
DE3852588D1 (de) 1995-02-09
AU2254588A (en) 1989-03-09
PT88229A (pt) 1989-06-30
JPH02504632A (ja) 1990-12-27
EP0303488A2 (fr) 1989-02-15
IE67318B1 (en) 1996-03-20
DE3852588T2 (de) 1995-05-11
ES2066787T3 (es) 1995-03-16
EP0303488B1 (fr) 1994-12-28
EP0303488A3 (en) 1989-05-03
NZ225767A (en) 1991-06-25
DK34590D0 (da) 1990-02-09
DK34590A (da) 1990-04-06
AU629179B2 (en) 1992-10-01
ATE116333T1 (de) 1995-01-15
GB8718937D0 (en) 1987-09-16
KR890701621A (ko) 1989-12-21
GR3015288T3 (en) 1995-06-30
BR8807658A (pt) 1990-08-07
MY103759A (en) 1993-09-30
WO1989001490A2 (fr) 1989-02-23
ZA885892B (en) 1990-04-25
HUT52788A (en) 1990-08-28
HU884790D0 (en) 1990-07-28
IE882432L (en) 1989-02-11
PT88229B (pt) 1995-03-01
LV10627B (en) 1995-08-20

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