HK1011353A1 - Diaminocyclobutene-3,4-diones as smooth muscle relaxants - Google Patents
Diaminocyclobutene-3,4-diones as smooth muscle relaxantsInfo
- Publication number
- HK1011353A1 HK1011353A1 HK98112276A HK98112276A HK1011353A1 HK 1011353 A1 HK1011353 A1 HK 1011353A1 HK 98112276 A HK98112276 A HK 98112276A HK 98112276 A HK98112276 A HK 98112276A HK 1011353 A1 HK1011353 A1 HK 1011353A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- smooth muscle
- muscle relaxants
- diaminocyclobutene
- diones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Pyridine Compounds (AREA)
- Pens And Brushes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/153,706 US5354763A (en) | 1993-11-17 | 1993-11-17 | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
PCT/US1994/012561 WO1995014005A1 (en) | 1993-11-17 | 1994-11-01 | Diaminocyclobutene-3,4-diones as smooth muscle relaxants |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1011353A1 true HK1011353A1 (en) | 1999-07-09 |
Family
ID=22548391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98112276A HK1011353A1 (en) | 1993-11-17 | 1998-11-24 | Diaminocyclobutene-3,4-diones as smooth muscle relaxants |
Country Status (22)
Country | Link |
---|---|
US (5) | US5354763A (xx) |
EP (1) | EP0729457B1 (xx) |
JP (1) | JPH09505296A (xx) |
KR (1) | KR960705780A (xx) |
AT (1) | ATE174907T1 (xx) |
AU (1) | AU677479B2 (xx) |
CA (1) | CA2175386A1 (xx) |
DE (1) | DE69415554T2 (xx) |
DK (1) | DK0729457T3 (xx) |
ES (1) | ES2126241T3 (xx) |
FI (1) | FI962070A (xx) |
GR (1) | GR3029646T3 (xx) |
HK (1) | HK1011353A1 (xx) |
HU (1) | HU215603B (xx) |
IL (1) | IL111529A (xx) |
LV (1) | LV12258B (xx) |
NZ (1) | NZ276568A (xx) |
PH (1) | PH31054A (xx) |
SG (1) | SG47587A1 (xx) |
SI (1) | SI0729457T1 (xx) |
WO (1) | WO1995014005A1 (xx) |
ZA (1) | ZA948877B (xx) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466712A (en) * | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
US5464867A (en) * | 1994-11-16 | 1995-11-07 | American Home Products Corporation | Diaminocyclobutene-3,4-diones |
BR9509699A (pt) * | 1994-11-16 | 1998-06-30 | American Home Prod | Diaminociclobuteno 3-4-dionas |
IL127261A0 (en) * | 1996-06-17 | 1999-09-22 | American Home Prod | Heterocyclylmethylamino derivatives of cyclobutene-3,4- diones as potassium channel modulators |
US5872139A (en) * | 1996-06-17 | 1999-02-16 | American Home Products Corporation | Heterocyclymethylamino derivatives of cyclobutene-3,4-diones |
US5780505A (en) * | 1996-07-17 | 1998-07-14 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones |
US5750574A (en) * | 1996-07-17 | 1998-05-12 | American Home Products Corporation | Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones |
US5763474A (en) * | 1996-07-17 | 1998-06-09 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
US5846999A (en) * | 1996-07-17 | 1998-12-08 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
AU6250298A (en) * | 1997-01-30 | 1998-08-25 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
US5840764A (en) * | 1997-01-30 | 1998-11-24 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
US6376555B1 (en) | 1998-12-04 | 2002-04-23 | American Home Products Corporation | 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers |
JP2003529532A (ja) * | 1998-12-04 | 2003-10-07 | ワイス | 4−3−置換−アミノ−シクロブト−3−エン−1,2−ジオン及び平滑筋収縮に影響を及ぼすための使用 |
WO2001038329A1 (fr) * | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Cristaux de mirtazapine anhydre et leur procede d'obtention |
US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
NZ543869A (en) * | 2001-04-16 | 2007-09-28 | Schering Corp | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine repcetor ligands |
US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
CN1599734A (zh) * | 2001-10-12 | 2005-03-23 | 先灵公司 | 作为cxc趋化因子受体拮抗剂的3,4-二取代的马来酰亚胺化合物 |
US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
CA2479126C (en) * | 2002-03-18 | 2011-11-15 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
DE60326080D1 (en) * | 2002-10-09 | 2009-03-19 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
TW200528450A (en) * | 2003-12-19 | 2005-09-01 | Schering Corp | Thiadiazoles as cxc-and cc-chemokine receptor ligands |
US7671212B2 (en) * | 2003-12-22 | 2010-03-02 | Schering Corporation | Isothiazole dioxides as CXC- and CC-chemokine receptor ligands |
ATE432921T1 (de) | 2004-12-23 | 2009-06-15 | Gpc Biotech Ag | Quadratsäurederivate mit antiproliferativer wirkung |
MX2008000366A (es) * | 2005-06-29 | 2008-03-07 | Schering Corp | Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina. |
DE602006017849D1 (de) * | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
EP2021316A1 (en) * | 2006-05-26 | 2009-02-11 | Abbott Laboratories | Inhibitors of polo-like kinases |
RU2009103999A (ru) * | 2006-07-07 | 2010-08-20 | Шеринг Корпорейшн (US) | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокиновых рецепторов |
US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
US9006426B2 (en) | 2008-06-24 | 2015-04-14 | Topotarget A/S | Squaric acid derivatives as inhibitors of the nicotinamide |
UA103198C2 (xx) * | 2008-08-04 | 2013-09-25 | Новартис Аг | Похідні сквараміду як антагоністи cxcr2$производные скварамида как антагонисты cxcr2 |
US9118048B2 (en) | 2009-09-04 | 2015-08-25 | Lg Fuel Cell Systems Inc. | Engine systems and methods of operating an engine |
US9178235B2 (en) | 2009-09-04 | 2015-11-03 | Lg Fuel Cell Systems, Inc. | Reducing gas generators and methods for generating a reducing gas |
US8668752B2 (en) * | 2009-09-04 | 2014-03-11 | Rolls-Royce Fuel Cell Systems (Us) Inc. | Apparatus for generating a gas which may be used for startup and shutdown of a fuel cell |
US9874158B2 (en) | 2009-09-04 | 2018-01-23 | Lg Fuel Cell Systems, Inc | Engine systems and methods of operating an engine |
US8597841B2 (en) | 2009-09-04 | 2013-12-03 | Lg Fuel Cell Systems Inc. | Method for generating a gas which may be used for startup and shutdown of a fuel cell |
US9083020B2 (en) | 2009-09-04 | 2015-07-14 | Lg Fuel Cell Systems Inc. | Reducing gas generators and methods for generating reducing gas |
US9140220B2 (en) | 2011-06-30 | 2015-09-22 | Lg Fuel Cell Systems Inc. | Engine systems and methods of operating an engine |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
EP3668832A1 (en) | 2017-08-14 | 2020-06-24 | Allergan, Inc. | 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof |
KR102615234B1 (ko) | 2018-09-21 | 2023-12-19 | 화이자 인코포레이티드 | Ccr6 억제제로서 유용한 n-치환된-디옥소시클로부테닐아미노-3-히드록시-피콜린아미드 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
EP0359537B1 (en) * | 1988-09-16 | 1996-06-26 | Beecham Group Plc | Benzopyran derivatives with antihypertensive activity |
GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
US5212283A (en) * | 1992-03-03 | 1993-05-18 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polyimides containing the cyclobutene-3, 4-dione moiety |
JPH0692915A (ja) * | 1992-07-28 | 1994-04-05 | Sumitomo Metal Ind Ltd | 1,2−ジアミノシクロブテン−3,4−ジオン誘導体及びその用途 |
-
1993
- 1993-11-17 US US08/153,706 patent/US5354763A/en not_active Expired - Lifetime
-
1994
- 1994-06-13 US US08/259,220 patent/US5397790A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,212 patent/US5403854A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,210 patent/US5403853A/en not_active Expired - Lifetime
- 1994-06-13 US US08/259,049 patent/US5401753A/en not_active Expired - Lifetime
- 1994-11-01 ES ES95901739T patent/ES2126241T3/es not_active Expired - Lifetime
- 1994-11-01 KR KR1019960702542A patent/KR960705780A/ko active IP Right Grant
- 1994-11-01 SI SI9430213T patent/SI0729457T1/xx unknown
- 1994-11-01 DE DE69415554T patent/DE69415554T2/de not_active Expired - Fee Related
- 1994-11-01 JP JP7514471A patent/JPH09505296A/ja not_active Ceased
- 1994-11-01 AU AU10866/95A patent/AU677479B2/en not_active Ceased
- 1994-11-01 DK DK95901739T patent/DK0729457T3/da active
- 1994-11-01 SG SG1996002966A patent/SG47587A1/en unknown
- 1994-11-01 NZ NZ276568A patent/NZ276568A/en unknown
- 1994-11-01 CA CA002175386A patent/CA2175386A1/en not_active Abandoned
- 1994-11-01 WO PCT/US1994/012561 patent/WO1995014005A1/en active IP Right Grant
- 1994-11-01 HU HU9601310A patent/HU215603B/hu not_active IP Right Cessation
- 1994-11-01 AT AT95901739T patent/ATE174907T1/de not_active IP Right Cessation
- 1994-11-01 EP EP95901739A patent/EP0729457B1/en not_active Expired - Lifetime
- 1994-11-04 IL IL11152994A patent/IL111529A/xx active IP Right Grant
- 1994-11-09 ZA ZA948877A patent/ZA948877B/xx unknown
- 1994-11-16 PH PH49383A patent/PH31054A/en unknown
-
1996
- 1996-05-15 FI FI962070A patent/FI962070A/fi unknown
-
1998
- 1998-11-24 HK HK98112276A patent/HK1011353A1/xx not_active IP Right Cessation
-
1999
- 1999-02-15 LV LVP-99-23A patent/LV12258B/en unknown
- 1999-03-09 GR GR990400737T patent/GR3029646T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA948877B (en) | 1996-05-09 |
GR3029646T3 (en) | 1999-06-30 |
SG47587A1 (en) | 1998-04-17 |
WO1995014005A1 (en) | 1995-05-26 |
SI0729457T1 (en) | 1999-04-30 |
PH31054A (en) | 1998-02-03 |
US5403854A (en) | 1995-04-04 |
FI962070A0 (fi) | 1996-05-15 |
AU1086695A (en) | 1995-06-06 |
DE69415554T2 (de) | 1999-05-12 |
US5397790A (en) | 1995-03-14 |
ATE174907T1 (de) | 1999-01-15 |
HUT75655A (en) | 1997-05-28 |
ES2126241T3 (es) | 1999-03-16 |
HU9601310D0 (en) | 1996-07-29 |
IL111529A0 (en) | 1995-01-24 |
DE69415554D1 (de) | 1999-02-04 |
DK0729457T3 (da) | 1999-08-23 |
CA2175386A1 (en) | 1995-05-26 |
NZ276568A (en) | 1996-11-26 |
LV12258B (en) | 1999-09-20 |
AU677479B2 (en) | 1997-04-24 |
IL111529A (en) | 1999-08-17 |
US5401753A (en) | 1995-03-28 |
KR960705780A (ko) | 1996-11-08 |
US5403853A (en) | 1995-04-04 |
JPH09505296A (ja) | 1997-05-27 |
FI962070A (fi) | 1996-05-15 |
EP0729457A1 (en) | 1996-09-04 |
EP0729457B1 (en) | 1998-12-23 |
US5354763A (en) | 1994-10-11 |
LV12258A (lv) | 1999-04-20 |
HU215603B (hu) | 1999-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20031101 |
|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |