HK1003425A1 - Oxypurine nucleosides and their congeners and acyl derivatives thereof for improvement of hematopoiesis - Google Patents

Oxypurine nucleosides and their congeners and acyl derivatives thereof for improvement of hematopoiesis

Info

Publication number
HK1003425A1
HK1003425A1 HK98102606A HK98102606A HK1003425A1 HK 1003425 A1 HK1003425 A1 HK 1003425A1 HK 98102606 A HK98102606 A HK 98102606A HK 98102606 A HK98102606 A HK 98102606A HK 1003425 A1 HK1003425 A1 HK 1003425A1
Authority
HK
Hong Kong
Prior art keywords
congeners
hematopoiesis
acyl derivatives
improvement
oxypurine nucleosides
Prior art date
Application number
HK98102606A
Other languages
English (en)
Inventor
Reid Warren Von Borstel
Michael Kevin Bamat
Bradley Mark Hiltbrand
James Charles Butler
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of HK1003425A1 publication Critical patent/HK1003425A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK98102606A 1991-02-08 1998-03-27 Oxypurine nucleosides and their congeners and acyl derivatives thereof for improvement of hematopoiesis HK1003425A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65388291A 1991-02-08 1991-02-08
PCT/US1992/000887 WO1992013561A1 (en) 1991-02-08 1992-02-05 Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis

Publications (1)

Publication Number Publication Date
HK1003425A1 true HK1003425A1 (en) 1998-10-30

Family

ID=24622651

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102606A HK1003425A1 (en) 1991-02-08 1998-03-27 Oxypurine nucleosides and their congeners and acyl derivatives thereof for improvement of hematopoiesis

Country Status (12)

Country Link
EP (1) EP0570519B1 (ja)
JP (6) JP3393645B2 (ja)
KR (2) KR100263943B1 (ja)
AT (1) ATE179615T1 (ja)
AU (1) AU663309C (ja)
CA (2) CA2444071C (ja)
DE (1) DE69229108T2 (ja)
HK (1) HK1003425A1 (ja)
IL (1) IL100874A (ja)
RU (1) RU2158269C2 (ja)
WO (1) WO1992013561A1 (ja)
ZA (1) ZA92914B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
SE9800452D0 (sv) * 1998-02-13 1998-02-13 Medivir Ab Antivirals
US6054441A (en) * 1987-10-28 2000-04-25 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DE69232070T2 (de) * 1991-07-05 2002-06-06 Pro-Neuron, Inc. Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
US5762922A (en) * 1994-01-31 1998-06-09 Ludwig Institute For Cancer Research Antioxidants and intracellular gluthathione raising agents for therapeutic treatments
RU2203669C2 (ru) * 1994-08-12 2003-05-10 Про-Нейрон Инк. Способы лечения сепсиса и воспалений с помощью оксипуриновых нуклеозидов
JP3844654B2 (ja) * 1997-08-15 2006-11-15 メディヴィル・アクチボラグ レトロウイルス逆転写酵素およびｂ型肝炎ウイルス（ｈｂｖ）のｄｎａポリメラーゼのインヒビターを含む抗ウイルス剤などのヌクレオシドアナログ
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
EP1567112B1 (en) * 2002-11-22 2008-10-15 Smithkline Beecham Corporation THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS
JP3929949B2 (ja) * 2003-08-08 2007-06-13 独立行政法人科学技術振興機構 酸化により機能性ユニットを放出するヌクレオシドおよびそれを含むオリゴヌクレオチドの製造法
WO2009045655A2 (en) 2007-08-16 2009-04-09 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions containing purine nucleosides and manganese and their uses
AU2016222458B2 (en) * 2007-08-16 2018-11-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions containing Nucleosides and Manganese and their Uses
BR112012027740B1 (pt) 2010-04-29 2021-02-17 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. composições contendo nucleosídeos de purina e pirimidina, peptídeos e maganês e seus usos
CN110339203A (zh) 2013-04-08 2019-10-18 得克萨斯系统大学评议会 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物
EP3758490A4 (en) * 2018-03-02 2021-12-22 January Therapeutics, Inc. COMPOSITIONS OF NANOPARTICLES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002963A (en) * 1975-05-29 1977-01-11 North Electric Company Converter circuit and method having fast responding current balance and limiting
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
US4849411A (en) * 1982-11-09 1989-07-18 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
GB2177914B (en) * 1985-06-04 1989-10-25 Chugai Pharmaceutical Co Ltd A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia
ATE93236T1 (de) * 1987-10-28 1993-09-15 Pro Neuron Inc Acylatiertes uridin und cytidin und deren verwendungen.
WO1989003838A1 (en) * 1987-10-28 1989-05-05 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
ATE111157T1 (de) * 1988-04-29 1994-09-15 Genetics Inst Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf.

Also Published As

Publication number Publication date
WO1992013561A1 (en) 1992-08-20
KR100418483B1 (ko) 2004-02-11
RU2158269C2 (ru) 2000-10-27
JP2006096772A (ja) 2006-04-13
DE69229108D1 (de) 1999-06-10
IL100874A (en) 1996-01-19
AU663309C (en) 2002-08-08
JP3393645B2 (ja) 2003-04-07
AU1417792A (en) 1992-09-07
JP2003064092A (ja) 2003-03-05
CA2444071C (en) 2008-10-07
EP0570519A1 (en) 1993-11-24
CA2100655C (en) 2004-02-03
CA2444071A1 (en) 1992-08-20
ZA92914B (en) 1993-08-09
JP3760149B2 (ja) 2006-03-29
KR100263943B1 (ko) 2000-08-16
JP2003119152A (ja) 2003-04-23
EP0570519A4 (en) 1996-02-21
EP0570519B1 (en) 1999-05-06
AU663309B2 (en) 1995-10-05
JP4067926B2 (ja) 2008-03-26
JP3996352B2 (ja) 2007-10-24
IL100874A0 (en) 1992-11-15
JPH06511473A (ja) 1994-12-22
JP2003160585A (ja) 2003-06-03
ATE179615T1 (de) 1999-05-15
CA2100655A1 (en) 1992-08-09
JP2001270896A (ja) 2001-10-02
JP3885006B2 (ja) 2007-02-21
DE69229108T2 (de) 1999-09-23

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100205