HK1003226A1 - Process for the preparation of substituted indolinone derivatives - Google Patents
Process for the preparation of substituted indolinone derivativesInfo
- Publication number
- HK1003226A1 HK1003226A1 HK98102343A HK98102343A HK1003226A1 HK 1003226 A1 HK1003226 A1 HK 1003226A1 HK 98102343 A HK98102343 A HK 98102343A HK 98102343 A HK98102343 A HK 98102343A HK 1003226 A1 HK1003226 A1 HK 1003226A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- indolinone derivatives
- substituted indolinone
- chem
- equivalents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
- C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878714371A GB8714371D0 (en) | 1987-06-19 | 1987-06-19 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1003226A1 true HK1003226A1 (en) | 1998-10-16 |
Family
ID=10619198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98102343A HK1003226A1 (en) | 1987-06-19 | 1998-03-19 | Process for the preparation of substituted indolinone derivatives |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4997954A (da) |
| EP (1) | EP0300614B1 (da) |
| JP (1) | JPH07596B2 (da) |
| KR (1) | KR0143088B1 (da) |
| CN (1) | CN1019296B (da) |
| AT (1) | ATE93521T1 (da) |
| AU (1) | AU600582B2 (da) |
| CA (1) | CA1326035C (da) |
| CY (1) | CY1951A (da) |
| DE (1) | DE3883456T2 (da) |
| DK (1) | DK169965B1 (da) |
| EG (1) | EG18412A (da) |
| ES (1) | ES2058285T3 (da) |
| FI (1) | FI89264C (da) |
| GB (1) | GB8714371D0 (da) |
| HK (1) | HK1003226A1 (da) |
| HU (4) | HU205339B (da) |
| IE (1) | IE62830B1 (da) |
| IL (1) | IL86736A (da) |
| MY (1) | MY103583A (da) |
| NO (1) | NO172577C (da) |
| NZ (1) | NZ225072A (da) |
| PH (1) | PH24608A (da) |
| PT (1) | PT87770B (da) |
| ZA (1) | ZA884334B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
| MX9304801A (es) * | 1992-08-06 | 1997-06-28 | Warner Lambert Co | 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales. |
| US5278162A (en) * | 1992-09-18 | 1994-01-11 | The Du Pont Merck Pharmaceutical Company | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man |
| GB9300309D0 (en) * | 1993-01-08 | 1993-03-03 | Smithkline Beecham Plc | Process |
| US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
| AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
| AU2002222642A1 (en) * | 2000-12-14 | 2002-06-24 | Nissan Chemical Industries Ltd. | Method for producing indole derivative |
| WO2005074387A2 (en) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride |
| US7378439B2 (en) * | 2004-01-20 | 2008-05-27 | Usv, Ltd. | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride |
| WO2005105741A1 (en) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
| EP1568689A1 (en) * | 2004-02-19 | 2005-08-31 | Helm AG | Process for the preparation of the 2-oxoindole derivative, Ropinirole |
| WO2005080333A1 (en) * | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Process for purification of ropinirole |
| CN1953967B (zh) * | 2004-04-27 | 2013-03-13 | 惠氏公司 | 孕酮受体调节剂的纯化 |
| US7968731B2 (en) | 2006-03-29 | 2011-06-28 | Alembic Limited | Process for the purification of Ropinirole hydrochloride |
| US20070254941A1 (en) * | 2006-04-21 | 2007-11-01 | Glenmark Pharmaceuticals Limited | Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation |
| CN100457732C (zh) * | 2006-05-25 | 2009-02-04 | 药源药物化学（上海）有限公司 | 罗匹尼罗的制备方法 |
| WO2010023693A2 (en) * | 2008-09-01 | 2010-03-04 | Lupin Limited | Novel controlled release compositions of ropinirole |
| ES2513691T3 (es) * | 2009-05-21 | 2014-10-27 | Hisamitsu Pharmaceutical Co., Inc. | Preparación transdérmica |
| US10961194B2 (en) | 2017-06-16 | 2021-03-30 | Zhejiang Huahai Licheng Pharmaceutical Co., Ltd. | Method for purifying ropinirole hydrochloride |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588740A (en) * | 1982-12-07 | 1986-05-13 | Smithkline Beckman Corporation | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones |
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| US4761485A (en) * | 1987-03-11 | 1988-08-02 | Pfizer Inc. | Synthetic method for indol-2(3H)-ones |
-
1987
- 1987-06-19 GB GB878714371A patent/GB8714371D0/en active Pending
-
1988
- 1988-06-13 CA CA000569292A patent/CA1326035C/en not_active Expired - Lifetime
- 1988-06-13 PH PH37063A patent/PH24608A/en unknown
- 1988-06-13 NO NO882588A patent/NO172577C/no not_active IP Right Cessation
- 1988-06-14 IL IL86736A patent/IL86736A/xx not_active IP Right Cessation
- 1988-06-15 US US07/207,351 patent/US4997954A/en not_active Expired - Lifetime
- 1988-06-16 ES ES88305510T patent/ES2058285T3/es not_active Expired - Lifetime
- 1988-06-16 DE DE88305510T patent/DE3883456T2/de not_active Expired - Lifetime
- 1988-06-16 AT AT88305510T patent/ATE93521T1/de not_active IP Right Cessation
- 1988-06-16 EP EP88305510A patent/EP0300614B1/en not_active Expired - Lifetime
- 1988-06-16 CN CN88103732A patent/CN1019296B/zh not_active Expired
- 1988-06-17 ZA ZA884334A patent/ZA884334B/xx unknown
- 1988-06-17 JP JP63151067A patent/JPH07596B2/ja not_active Expired - Lifetime
- 1988-06-17 DK DK334788A patent/DK169965B1/da not_active IP Right Cessation
- 1988-06-17 HU HU911599A patent/HU205339B/hu not_active IP Right Cessation
- 1988-06-17 HU HU893988A patent/HU203723B/hu not_active IP Right Cessation
- 1988-06-17 MY MYPI88000674A patent/MY103583A/en unknown
- 1988-06-17 FI FI882919A patent/FI89264C/fi active IP Right Grant
- 1988-06-17 AU AU18119/88A patent/AU600582B2/en not_active Expired
- 1988-06-17 HU HU883123A patent/HU202200B/hu unknown
- 1988-06-17 KR KR1019880007283A patent/KR0143088B1/ko not_active IP Right Cessation
- 1988-06-17 NZ NZ225072A patent/NZ225072A/xx unknown
- 1988-06-17 PT PT87770A patent/PT87770B/pt not_active IP Right Cessation
- 1988-06-17 HU HU906948A patent/HUT55360A/hu unknown
- 1988-06-17 IE IE183788A patent/IE62830B1/en not_active IP Right Cessation
- 1988-06-19 EG EG342/88A patent/EG18412A/xx active
-
1997
- 1997-05-16 CY CY195197A patent/CY1951A/xx unknown
-
1998
- 1998-03-19 HK HK98102343A patent/HK1003226A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PE | Patent expired |
Effective date: 20080615 |