GT201800018A - Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana - Google Patents

Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana

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Publication number
GT201800018A
GT201800018A GT201800018A GT201800018A GT201800018A GT 201800018 A GT201800018 A GT 201800018A GT 201800018 A GT201800018 A GT 201800018A GT 201800018 A GT201800018 A GT 201800018A GT 201800018 A GT201800018 A GT 201800018A
Authority
GT
Guatemala
Prior art keywords
antibody
functionality
improved binding
safety characteristics
human immunotherapy
Prior art date
Application number
GT201800018A
Other languages
English (en)
Spanish (es)
Inventor
Jay Rothstein
Robert George Edward Holgate
Arron Hearn
Original Assignee
Immunext Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunext Inc filed Critical Immunext Inc
Publication of GT201800018A publication Critical patent/GT201800018A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
GT201800018A 2015-07-14 2018-01-12 Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana GT201800018A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562192269P 2015-07-14 2015-07-14
US201562197966P 2015-07-28 2015-07-28
US201662277201P 2016-01-11 2016-01-11

Publications (1)

Publication Number Publication Date
GT201800018A true GT201800018A (es) 2019-08-08

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GT201800018A GT201800018A (es) 2015-07-14 2018-01-12 Anticuerpo anti-cd154 con características de unión, funcionalidad y seguridad mejoradas y uso en inmunoterapia humana

Country Status (22)

Country Link
US (3) US10874738B2 (OSRAM)
EP (1) EP3331548A4 (OSRAM)
JP (4) JP6826113B2 (OSRAM)
KR (2) KR20250099272A (OSRAM)
CN (2) CN108135969B (OSRAM)
AU (3) AU2016294417B2 (OSRAM)
CL (1) CL2018000103A1 (OSRAM)
CO (1) CO2018001363A2 (OSRAM)
CR (1) CR20180097A (OSRAM)
DO (1) DOP2018000018A (OSRAM)
EA (1) EA201890297A1 (OSRAM)
EC (1) ECSP18009949A (OSRAM)
GT (1) GT201800018A (OSRAM)
HK (1) HK1249735A1 (OSRAM)
IL (3) IL297907B2 (OSRAM)
MX (2) MX2018000548A (OSRAM)
MY (2) MY196991A (OSRAM)
PE (1) PE20180741A1 (OSRAM)
PH (1) PH12018500098A1 (OSRAM)
SG (1) SG10201913431QA (OSRAM)
TN (1) TN2018000021A1 (OSRAM)
WO (1) WO2017011544A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108135969B (zh) * 2015-07-14 2022-03-04 里姆蒙埃克斯特股份有限公司 具有改善的结合、功能和安全性特征的抗cd154抗体及其在人免疫治疗中的用途
KR20180080337A (ko) 2015-11-27 2018-07-11 아블린쓰 엔.브이. Ｃｄ40ｌ을 억제하는 폴리펩티드
CA3096222A1 (en) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
WO2020056162A1 (en) * 2018-09-12 2020-03-19 Oregon Health & Science University Detecting and/or subtyping circulating hybrid cells that correlate with stage and survival
CN112770774A (zh) * 2018-09-24 2021-05-07 詹森生物科技公司 提供安全施用抗cd154抗体的方法
CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
EP3952853A4 (en) * 2019-04-12 2023-04-12 Tonix Pharmaceuticals Holding Corp. INHIBITORS OF CD40-CD154 BINDING
US11807687B2 (en) 2019-10-03 2023-11-07 Atyr Pharma, Inc. Therapeutic compositions comprising anti-NRP2 antibodies
CN113488170B (zh) * 2021-07-02 2023-07-25 温州医科大学 急性前葡萄膜炎复发风险预测模型构建方法及相关设备
US20240336690A1 (en) * 2021-07-30 2024-10-10 Seoul National University R&Db Foundation Anti cd154 antibody and use thereof
KR20230019798A (ko) * 2021-07-30 2023-02-09 서울대학교산학협력단 항 cd154 항체 및 이의 용도
WO2024211211A1 (en) 2023-04-03 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies
WO2024222895A1 (zh) 2023-04-28 2024-10-31 信达生物制药(苏州)有限公司 抗cd40l抗体及其在人自身免疫疾病治疗的应用
TW202508631A (zh) * 2023-05-22 2025-03-01 美商健臻公司 使用抗cd40l抗體治療多發性硬化症

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100341896C (zh) 1993-09-02 2007-10-10 达特茅斯学院理事 抗gp39抗体及其应用
US6440418B1 (en) 1995-11-07 2002-08-27 Idec Pharmaceuticals Corporation Methods of treating autoimmune diseases with gp39-specific antibodies
US6001358A (en) 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
US6242195B1 (en) 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
US6444018B1 (en) 1998-06-25 2002-09-03 Xerox Corporation Phase change ink carrier compositions containing anhydride/amino alcohol-based adducts
GB0006398D0 (en) * 2000-03-16 2000-05-03 Novartis Ag Organic compounds
TR200602095T2 (tr) * 2000-10-13 2007-02-21 Biogen Idec Ma Inc. Hümanize Anti-LT-Beta-R antikorları
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
NZ544486A (en) * 2003-06-13 2009-04-30 Biogen Idec Inc Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof
CN1871259A (zh) 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 具有改变的效应物功能的经改进的抗体和制备它的方法
WO2006104989A2 (en) 2005-03-29 2006-10-05 Verenium Corporation Altered antibody fc regions and uses thereof
HUE041818T2 (hu) * 2007-03-22 2019-05-28 Biogen Ma Inc Kötõ proteinek, beleértve az antitesteket, CD154-et specifikusan kötõ antitest származékokat és antitest fragmenseket is, és alkalmazásaik
US8852597B2 (en) * 2011-04-04 2014-10-07 The Trustees Of Dartmouth College Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties
US9321833B2 (en) 2011-04-04 2016-04-26 The Trustees Of Dartmouth College Methods of therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties
CN108135969B (zh) * 2015-07-14 2022-03-04 里姆蒙埃克斯特股份有限公司 具有改善的结合、功能和安全性特征的抗cd154抗体及其在人免疫治疗中的用途

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MY196991A (en) 2023-05-17
MX2023014921A (es) 2024-02-16
CA2992116A1 (en) 2017-01-19
WO2017011544A1 (en) 2017-01-19
DOP2018000018A (es) 2019-10-15
CO2018001363A2 (es) 2018-05-10
CN108135969A (zh) 2018-06-08
US20240000929A1 (en) 2024-01-04
IL256800B2 (en) 2023-04-01
PE20180741A1 (es) 2018-04-27
BR112018000653A2 (pt) 2018-09-18
EA201890297A1 (ru) 2018-06-29
AU2016294417A1 (en) 2018-03-08
ECSP18009949A (es) 2018-10-31
JP7605914B2 (ja) 2024-12-24
IL297907B2 (en) 2024-07-01
KR20180037984A (ko) 2018-04-13
NZ739859A (en) 2024-08-30
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