GT201000146A - Derivados de alcanos azabicíclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotínicos de acetilcolina - Google Patents
Derivados de alcanos azabicíclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotínicos de acetilcolinaInfo
- Publication number
- GT201000146A GT201000146A GT201000146A GT201000146A GT201000146A GT 201000146 A GT201000146 A GT 201000146A GT 201000146 A GT201000146 A GT 201000146A GT 201000146 A GT201000146 A GT 201000146A GT 201000146 A GT201000146 A GT 201000146A
- Authority
- GT
- Guatemala
- Prior art keywords
- biarilo
- azabycyclic
- acetilcoline
- modulators
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A DERIVADOS DE ALCANOS AZABICÍCLICOS SUSTITUIDOS CON BIARILO ÚTILES COMO MODULADORES DE LA ACTIVIDAD DE LOS RECEPTORES NICOTÍNICOS DE ACETILCOLINA LOS CUALES ESTÁN AMPLIAMENTE DISTRIBUIDOS EN LOS SISTEMAS NERVIOSO CENTRAL Y PERIFÉRICO QUE MODULAN LA LIBERACIÓN DE UN AMPLIO RANGO DE NEUROTRANSMISORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98953807P | 2007-11-21 | 2007-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201000146A true GT201000146A (es) | 2012-04-19 |
Family
ID=40263587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201000146A GT201000146A (es) | 2007-11-21 | 2010-05-19 | Derivados de alcanos azabicíclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotínicos de acetilcolina |
Country Status (21)
Country | Link |
---|---|
US (2) | US7902222B2 (es) |
EP (2) | EP2280010B1 (es) |
JP (2) | JP5693229B2 (es) |
KR (1) | KR20100090706A (es) |
CN (1) | CN101925599A (es) |
AU (1) | AU2008326360A1 (es) |
BR (1) | BRPI0820418A2 (es) |
CA (1) | CA2705296A1 (es) |
CO (1) | CO6280476A2 (es) |
CR (1) | CR11522A (es) |
DO (1) | DOP2010000149A (es) |
EC (1) | ECSP10010296A (es) |
GT (1) | GT201000146A (es) |
IL (1) | IL205763A0 (es) |
MX (1) | MX2010005648A (es) |
NZ (1) | NZ585055A (es) |
RU (1) | RU2010125121A (es) |
SG (1) | SG186018A1 (es) |
UA (1) | UA99936C2 (es) |
WO (1) | WO2009067579A1 (es) |
ZA (1) | ZA201003289B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
ES2525076T3 (es) * | 2006-05-19 | 2014-12-17 | Abbvie Bahamas Ltd. | Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclos condensados activos en el SNC |
AU2008326360A1 (en) * | 2007-11-21 | 2009-05-28 | Abbott Laboratories | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
FR2937641A1 (fr) | 2008-10-28 | 2010-04-30 | Sanofi Aventis | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
BRPI0922057A2 (pt) | 2008-11-19 | 2015-12-15 | Envivo Pharmaceuticals Inc | tratamento dos transtorno cognitivos com (r)-7-cloro-n-(quiniclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmeceuticamente aceitaveis do mesmo |
CN102802620A (zh) * | 2009-05-11 | 2012-11-28 | 英维沃医药有限公司 | 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍 |
CA2787063C (en) * | 2010-01-11 | 2018-11-27 | Astraea Therapeutics, Llc | Nicotinic acetylcholine receptor modulators |
UY33389A (es) | 2010-05-17 | 2011-12-30 | Mitsubishi Tanabe Pharma Corp | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidrato |
AU2012230890A1 (en) | 2011-03-22 | 2013-09-26 | Amgen Inc. | Azole compounds as Pim inhibitors |
RU2017136693A (ru) | 2012-05-08 | 2019-02-08 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
WO2014164682A1 (en) | 2013-03-12 | 2014-10-09 | Abbvie Inc. | Azaadamantane formate ester and process preparing azaadamantane derivatives |
US10183938B2 (en) | 2014-12-16 | 2019-01-22 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors |
EP3307269A4 (en) | 2015-06-10 | 2019-02-20 | Axovant Sciences GmbH | AMINOBENZIS OXAZOL COMPOUNDS AS AGONISTS OF A7 NICOTINE ACETYLCHOLIN RECEPTORS |
WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
TWI712590B (zh) * | 2015-11-10 | 2020-12-11 | 國立大學法人九州大學 | 二氰基吡𠯤化合物、發光材料、使用其之發光元件 |
SG11202000980QA (en) | 2017-08-04 | 2020-02-27 | Skyhawk Therapeutics Inc | Methods and compositions for modulating splicing |
CN109593088B (zh) * | 2018-12-27 | 2022-03-25 | 华东理工大学 | 氮杂双环衍生物及其制备和应用 |
KR20210135242A (ko) * | 2019-02-04 | 2021-11-12 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
JP2022521467A (ja) | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
CN113677344A (zh) | 2019-02-06 | 2021-11-19 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995005379A1 (en) * | 1993-08-19 | 1995-02-23 | Novo Nordisk A/S | Antipsychotic method |
US5929247A (en) * | 1994-10-24 | 1999-07-27 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
US5880121A (en) * | 1996-01-05 | 1999-03-09 | Hoechst Marion Roussel Inc. | 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof |
EP1185513A2 (en) | 1999-05-24 | 2002-03-13 | Targacept, Inc. | Aryl substituted alkylamines capable of activating nicotinic cholinergic receptors |
EP1472248A1 (en) * | 2002-01-17 | 2004-11-03 | Eli Lilly And Company | Modulators of acetylcholine receptors |
US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
US7202363B2 (en) | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
MX2007011436A (es) * | 2005-03-18 | 2007-10-12 | Abbott Lab | Ligando del receptor nicotinico neuronal 7 y composiciones antipsicoticas. |
US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
TW200806662A (en) * | 2005-12-01 | 2008-02-01 | Organon Nv | 8-azabicyclo[3.2.1]octane derivatives |
ES2525076T3 (es) * | 2006-05-19 | 2014-12-17 | Abbvie Bahamas Ltd. | Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclos condensados activos en el SNC |
AU2008326360A1 (en) * | 2007-11-21 | 2009-05-28 | Abbott Laboratories | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
-
2008
- 2008-11-20 AU AU2008326360A patent/AU2008326360A1/en not_active Abandoned
- 2008-11-20 KR KR1020107013615A patent/KR20100090706A/ko not_active Application Discontinuation
- 2008-11-20 UA UAA201007604A patent/UA99936C2/ru unknown
- 2008-11-20 NZ NZ585055A patent/NZ585055A/en not_active IP Right Cessation
- 2008-11-20 JP JP2010535054A patent/JP5693229B2/ja not_active Expired - Fee Related
- 2008-11-20 EP EP10173074A patent/EP2280010B1/en active Active
- 2008-11-20 MX MX2010005648A patent/MX2010005648A/es active IP Right Grant
- 2008-11-20 US US12/274,529 patent/US7902222B2/en not_active Expired - Fee Related
- 2008-11-20 CN CN2008801252360A patent/CN101925599A/zh active Pending
- 2008-11-20 CA CA2705296A patent/CA2705296A1/en not_active Abandoned
- 2008-11-20 BR BRPI0820418-7A patent/BRPI0820418A2/pt not_active IP Right Cessation
- 2008-11-20 SG SG2012085437A patent/SG186018A1/en unknown
- 2008-11-20 WO PCT/US2008/084148 patent/WO2009067579A1/en active Application Filing
- 2008-11-20 RU RU2010125121/04A patent/RU2010125121A/ru not_active Application Discontinuation
- 2008-11-20 EP EP08852111A patent/EP2231657A1/en not_active Withdrawn
-
2010
- 2010-05-10 ZA ZA2010/03289A patent/ZA201003289B/en unknown
- 2010-05-13 IL IL205763A patent/IL205763A0/en unknown
- 2010-05-19 DO DO2010000149A patent/DOP2010000149A/es unknown
- 2010-05-19 GT GT201000146A patent/GT201000146A/es unknown
- 2010-06-03 CO CO10067133A patent/CO6280476A2/es not_active Application Discontinuation
- 2010-06-21 CR CR11522A patent/CR11522A/es not_active Application Discontinuation
- 2010-06-21 EC EC2010010296A patent/ECSP10010296A/es unknown
-
2011
- 2011-01-27 US US13/014,947 patent/US8853241B2/en not_active Expired - Fee Related
-
2014
- 2014-12-25 JP JP2014261773A patent/JP2015110583A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2009067579A1 (en) | 2009-05-28 |
EP2280010A2 (en) | 2011-02-02 |
ECSP10010296A (es) | 2010-07-30 |
DOP2010000149A (es) | 2010-06-30 |
JP2011504181A (ja) | 2011-02-03 |
CO6280476A2 (es) | 2011-05-20 |
EP2231657A1 (en) | 2010-09-29 |
JP2015110583A (ja) | 2015-06-18 |
NZ585055A (en) | 2012-07-27 |
MX2010005648A (es) | 2010-06-02 |
CN101925599A (zh) | 2010-12-22 |
RU2010125121A (ru) | 2011-12-27 |
UA99936C2 (en) | 2012-10-25 |
CR11522A (es) | 2010-08-12 |
SG186018A1 (en) | 2012-12-28 |
ZA201003289B (en) | 2012-10-31 |
KR20100090706A (ko) | 2010-08-16 |
AU2008326360A1 (en) | 2009-05-28 |
US20090192186A1 (en) | 2009-07-30 |
CA2705296A1 (en) | 2009-05-28 |
EP2280010B1 (en) | 2012-12-19 |
EP2280010A3 (en) | 2011-05-04 |
US7902222B2 (en) | 2011-03-08 |
US20110124676A1 (en) | 2011-05-26 |
BRPI0820418A2 (pt) | 2015-05-19 |
IL205763A0 (en) | 2010-11-30 |
US8853241B2 (en) | 2014-10-07 |
JP5693229B2 (ja) | 2015-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GT201000146A (es) | Derivados de alcanos azabicíclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotínicos de acetilcolina | |
PA8836801A1 (es) | Polipeptidos g-csf de bovino modificados y sus usos | |
NI201200020A (es) | Derivados de n1 - sulfonil - 5 - fluoropirimidinona | |
ECSP12011654A (es) | Derivados de 5-fluoropirimidinona | |
CR20110044A (es) | Uso de 5-fluorocitosina como un fungicida | |
CR20160272A (es) | REGULADORES DE Nrf2 | |
GT201300196A (es) | Moduladores del receptor de glucagón | |
GT201000023A (es) | Nuevos derivados de 6-trialzolopiridacina-sulfanil benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de met. | |
DOP2013000307A (es) | Antagonistas de trpv4 | |
CO6592042A2 (es) | Derivados de n3-sustituido -n1-sulfonil-5-fluorpirimidinona | |
UY34484A (es) | Benzotienilo-pirrolotriazinas disustituidas y sus usos | |
CL2012000921A1 (es) | Compuestos derivados de espiropiperidina-metilbenciloxifenil, activadores del receptor rpg-40; composicion farmaceutica que los comprende; y uso del compuesto para tratar diabetes. | |
SV2009003429A (es) | Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica | |
CO6470826A2 (es) | Moduladores de lxr | |
HN2012000261A (es) | Derivados de 5-fluoro-2-oxopirimidina-1(2h)-carboxilato | |
GT201200154A (es) | Derivados de piridino-piridinonas, su preparación y su aplicación en terapéutica | |
ECSP12011653A (es) | Derivados de n1-acil-5-fluoropirimidinona | |
ECSP12011652A (es) | Derivados de 5-fluoro-2-oxopirimidinona-1 (2h)-carboxamida substituida-n1 | |
BR112015027396A8 (pt) | derivados de purina como agonistas do receptor de cb2 | |
HN2010001537A (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
ECSP14013305A (es) | Moduladores selectivos del receptor andrógeno | |
CR20140124A (es) | Metabolitos de transclomifeno y usos de los mismos | |
CO6761304A2 (es) | Nuevos compuestos de bezodioxol-piperazina | |
UY34407A (es) | Nuevos moduladores de trpv3 | |
UY33409A (es) | Moduladores no competitivos de receptores nicotinicos |