GT200900010A - Derivados de amino-piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp) - Google Patents
Derivados de amino-piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp)Info
- Publication number
- GT200900010A GT200900010A GT200900010A GT200900010A GT200900010A GT 200900010 A GT200900010 A GT 200900010A GT 200900010 A GT200900010 A GT 200900010A GT 200900010 A GT200900010 A GT 200900010A GT 200900010 A GT200900010 A GT 200900010A
- Authority
- GT
- Guatemala
- Prior art keywords
- cholesteril
- cetp
- inhibitors
- amino
- transfer protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE UTILIDAD COMO INHIBIDORES PARA LA PROTEINA DE TRANSFERENCIA DE COLESTERIL-ESTER (CETP) EL CUAL ES UN GLICOPEPTIDO DE 74KD QUE ES SECRETADA POR EL HIGADO Y ES UN PARTICIPANTE CLAVE PARA FACILITAR LA TRANSFERENCIA DE LIPIDOS ENTRE LAS DIFERENTES LIPOPROTEINAS EN PLASMA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06117541 | 2006-07-20 | ||
US88705807P | 2007-01-29 | 2007-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200900010A true GT200900010A (es) | 2009-06-24 |
Family
ID=38695303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200900010A GT200900010A (es) | 2006-07-20 | 2009-01-16 | Derivados de amino-piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp) |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090286790A1 (es) |
EP (1) | EP2049517B1 (es) |
JP (1) | JP5042311B2 (es) |
KR (1) | KR101149274B1 (es) |
AR (1) | AR061926A1 (es) |
AU (1) | AU2007276433B2 (es) |
CA (1) | CA2657258A1 (es) |
CL (1) | CL2007002107A1 (es) |
CO (1) | CO6150155A2 (es) |
CR (1) | CR10478A (es) |
EC (1) | ECSP099078A (es) |
GT (1) | GT200900010A (es) |
HK (1) | HK1132262A1 (es) |
HR (1) | HRP20140183T1 (es) |
IL (1) | IL195792A (es) |
MA (1) | MA30638B1 (es) |
MX (1) | MX2009000646A (es) |
NO (1) | NO342106B1 (es) |
PE (1) | PE20080404A1 (es) |
PL (1) | PL2049517T3 (es) |
TN (1) | TN2009000012A1 (es) |
TW (1) | TWI387593B (es) |
WO (1) | WO2008009435A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201070143A1 (ru) * | 2007-07-13 | 2010-08-30 | Аддекс Фарма С.А. | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
MX2010004929A (es) | 2007-11-05 | 2010-05-27 | Novartis Ag | Derivados de 4-bencil-amino-1-carboxi-acil-piperidina como inhibidores de proteina de transferencia de colesterol-ester (cetp) utiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis. |
ES2425776T3 (es) * | 2007-12-03 | 2013-10-17 | Novartis Ag | Derivados 1,2-disustituidos de 4-bencilamino-pirrolidina como inhibidores CETP útiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis |
US8258306B2 (en) | 2007-12-12 | 2012-09-04 | Amgen Inc. | Glycine transporter-1 inhibitors |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
CN103221405B (zh) | 2010-07-09 | 2015-04-22 | 第一三共株式会社 | 取代的吡啶化合物 |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
SG10201605304VA (en) | 2011-07-08 | 2016-08-30 | Novartis Ag | Method of treating atherosclerosis in high triglyceride subjects |
JP6097225B2 (ja) | 2012-01-06 | 2017-03-15 | 第一三共株式会社 | 置換ピリジン化合物の酸付加塩 |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
DK2956464T3 (en) | 2013-02-14 | 2018-07-16 | Novartis Ag | Substituted bisphenyl-butane phosphonic acid derivatives as NEP (neutral endopeptidase) inhibitors |
JP2014172851A (ja) * | 2013-03-07 | 2014-09-22 | Chiba Univ | ピラゾール誘導体の製造方法およびイソオキサゾール誘導体の製造方法 |
EP3024492A2 (en) | 2013-07-25 | 2016-06-01 | Novartis AG | Bioconjugates of synthetic apelin polypeptides |
PE20160878A1 (es) | 2013-07-25 | 2016-09-08 | Novartis Ag | Polipeptidos ciclicos para el tratamiento de la insuficiencia cardiaca |
JP6402907B2 (ja) * | 2014-09-24 | 2018-10-10 | Jnc株式会社 | ピペリジン誘導体、液晶組成物および液晶表示素子 |
CU20170093A7 (es) | 2015-01-23 | 2017-09-06 | Novartis Ag | Conjugados de ácidos grasos y apelina sintética con mayor vida media |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
CN110508018B (zh) * | 2019-09-03 | 2022-02-25 | 中国石油大学(华东) | 生产聚甲氧基二甲醚的装置及方法 |
CA3157681A1 (en) | 2019-10-11 | 2021-04-15 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
TW313568B (es) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
US6140342A (en) | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
ATE296796T1 (de) | 1998-09-25 | 2005-06-15 | Monsanto Co | (r)-chirale halogenierte 1-substituierte amino- (n+1)-alkanolen für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
ATE533513T1 (de) | 2002-09-06 | 2011-12-15 | Cerulean Pharma Inc | Polymere auf basis von cyclodextrin zur verabreichung von an diese kovalent gebundene arzneimittel |
JP2007519605A (ja) | 2004-01-30 | 2007-07-19 | 日本たばこ産業株式会社 | 食欲抑制薬 |
MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
ES2425776T3 (es) * | 2007-12-03 | 2013-10-17 | Novartis Ag | Derivados 1,2-disustituidos de 4-bencilamino-pirrolidina como inhibidores CETP útiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis |
-
2007
- 2007-07-18 US US12/374,463 patent/US20090286790A1/en not_active Abandoned
- 2007-07-18 PL PL07786158T patent/PL2049517T3/pl unknown
- 2007-07-18 KR KR1020097001089A patent/KR101149274B1/ko not_active IP Right Cessation
- 2007-07-18 AU AU2007276433A patent/AU2007276433B2/en not_active Ceased
- 2007-07-18 WO PCT/EP2007/006384 patent/WO2008009435A1/en active Application Filing
- 2007-07-18 MX MX2009000646A patent/MX2009000646A/es active IP Right Grant
- 2007-07-18 EP EP07786158.1A patent/EP2049517B1/en active Active
- 2007-07-18 JP JP2009519868A patent/JP5042311B2/ja not_active Expired - Fee Related
- 2007-07-18 AR ARP070103209A patent/AR061926A1/es unknown
- 2007-07-18 CA CA002657258A patent/CA2657258A1/en not_active Abandoned
- 2007-07-19 CL CL200702107A patent/CL2007002107A1/es unknown
- 2007-07-19 TW TW096126359A patent/TWI387593B/zh not_active IP Right Cessation
- 2007-07-19 PE PE2007000936A patent/PE20080404A1/es not_active Application Discontinuation
-
2008
- 2008-12-02 CR CR10478A patent/CR10478A/es unknown
- 2008-12-08 IL IL195792A patent/IL195792A/en active IP Right Grant
-
2009
- 2009-01-16 GT GT200900010A patent/GT200900010A/es unknown
- 2009-01-16 TN TN2009000012A patent/TN2009000012A1/fr unknown
- 2009-01-19 EC EC2009009078A patent/ECSP099078A/es unknown
- 2009-01-20 CO CO09004534A patent/CO6150155A2/es unknown
- 2009-02-11 MA MA31630A patent/MA30638B1/fr unknown
- 2009-02-17 NO NO20090756A patent/NO342106B1/no not_active IP Right Cessation
- 2009-10-20 HK HK09109684.3A patent/HK1132262A1/xx not_active IP Right Cessation
-
2014
- 2014-02-27 HR HRP20140183TT patent/HRP20140183T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
MX2009000646A (es) | 2009-01-29 |
HK1132262A1 (en) | 2010-02-19 |
AU2007276433B2 (en) | 2011-06-16 |
CR10478A (es) | 2009-02-02 |
PE20080404A1 (es) | 2008-06-27 |
CO6150155A2 (es) | 2010-04-20 |
TW200813022A (en) | 2008-03-16 |
TN2009000012A1 (en) | 2010-08-19 |
JP5042311B2 (ja) | 2012-10-03 |
IL195792A0 (en) | 2009-09-01 |
KR101149274B1 (ko) | 2012-05-29 |
TWI387593B (zh) | 2013-03-01 |
PL2049517T3 (pl) | 2014-06-30 |
HRP20140183T1 (hr) | 2014-04-11 |
AR061926A1 (es) | 2008-10-01 |
NO342106B1 (no) | 2018-03-26 |
EP2049517A1 (en) | 2009-04-22 |
NO20090756L (no) | 2009-04-14 |
AU2007276433A1 (en) | 2008-01-24 |
JP2009543827A (ja) | 2009-12-10 |
MA30638B1 (fr) | 2009-08-03 |
CA2657258A1 (en) | 2008-01-24 |
ECSP099078A (es) | 2009-02-27 |
WO2008009435A1 (en) | 2008-01-24 |
US20090286790A1 (en) | 2009-11-19 |
IL195792A (en) | 2013-07-31 |
CL2007002107A1 (es) | 2008-06-06 |
EP2049517B1 (en) | 2013-11-27 |
KR20090031579A (ko) | 2009-03-26 |
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