GT199900003A - Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
GT199900003A
GT199900003A GT199900003A GT199900003A GT199900003A GT 199900003 A GT199900003 A GT 199900003A GT 199900003 A GT199900003 A GT 199900003A GT 199900003 A GT199900003 A GT 199900003A GT 199900003 A GT199900003 A GT 199900003A
Authority
GT
Guatemala
Prior art keywords
sequence
synthesis
polysaccharides
procedure
contain
Prior art date
Application number
GT199900003A
Other languages
English (en)
Inventor
Johannes Basten
Cornelia Dreef-Tromp
Pierre Alexandre Driguez
Philippe Duchaussoy
Jean-Marc Herbert
Maurice Petitou
Constant Adriaan Anton Van Boeckel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199900003A publication Critical patent/GT199900003A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

EN ESTA SOLICITUD DE PATENTE, SE DESCRIBEN NUEVOS DERIVADOS POLISACARIDOS BIOLOGICAMENTE ACTIVOS. SON PARTICULARMENTE, ANTICOAGULANTES Y ANTITROMBOTICOS. POR OTRA PARTE, DEBIDO A LA OBTENCION POR SINTESIS DE ESOS POLISACARIDOS, ES POSIBLE MODIFICAR SELECTIVAMENTE SU ESTRUCTURA. ESOS COMPUESTOS SON HEXADECASACARIDOS QUE COMPRENDEN TRES SECUENCIAS DISTINTAS: UNA SECUENCIA PENTASACARIDICA SULFATADA DEFGH, UNA SECUENCIA HEPTASACARIDICA NO SULFATADA Z(MN)3 Y UNA SECUENCIA TETRASACARIDICA SULFATADA V W X Y. LOS COMPUESTOS CONFORMES A LA PRESENTE INVENCION SON POLISACARIDOS DE SINTESIS EN FORMA ACIDA Y SUS SALES FARMACEUTICAMENTE ACEPTABLES CON CATIONES FARMACEUTICAMENTE ACEPTABLES, CUYA FORMA ANIONICA RESPONDE A UNA DE LAS FORMULAS DESCRITAS EN EL EXPEDIENTE.
GT199900003A 1998-01-19 1999-01-14 Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. GT199900003A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9800515A FR2773804B1 (fr) 1998-01-19 1998-01-19 Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant

Publications (1)

Publication Number Publication Date
GT199900003A true GT199900003A (es) 2000-07-07

Family

ID=9521914

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900003A GT199900003A (es) 1998-01-19 1999-01-14 Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (41)

Country Link
US (1) US6528497B1 (es)
EP (1) EP1049721B1 (es)
JP (1) JP4402835B2 (es)
KR (1) KR100513196B1 (es)
CN (1) CN1165550C (es)
AR (1) AR013019A1 (es)
AT (1) ATE209219T1 (es)
AU (1) AU741748B2 (es)
BR (1) BRPI9907025B8 (es)
CA (1) CA2317465C (es)
CO (1) CO4970795A1 (es)
CZ (1) CZ297815B6 (es)
DE (1) DE69900718T2 (es)
DK (1) DK1049721T3 (es)
DZ (1) DZ2709A1 (es)
EE (1) EE04157B1 (es)
EG (1) EG23982A (es)
ES (1) ES2168000T3 (es)
FR (1) FR2773804B1 (es)
GT (1) GT199900003A (es)
HK (1) HK1030002A1 (es)
HR (1) HRP20000480B1 (es)
HU (1) HU228333B1 (es)
IL (1) IL137241A0 (es)
MA (1) MA26597A1 (es)
MY (1) MY119090A (es)
NO (1) NO329903B1 (es)
NZ (1) NZ505492A (es)
PE (1) PE20000269A1 (es)
PL (1) PL202802B1 (es)
PT (1) PT1049721E (es)
RU (1) RU2211224C2 (es)
SA (1) SA99191113B1 (es)
SI (1) SI1049721T1 (es)
SK (1) SK283411B6 (es)
TR (1) TR200002078T2 (es)
TW (1) TW548279B (es)
UA (1) UA60352C2 (es)
UY (1) UY25356A1 (es)
WO (1) WO1999036443A1 (es)
ZA (1) ZA99355B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
IL188647A0 (en) * 2008-01-08 2008-11-03 Orina Gribova Adaptable structured drug and supplements administration system (for oral and/or transdermal applications)
WO2009130704A1 (en) * 2008-04-24 2009-10-29 Technion Research And Development Foundation Ltd. Beta-lactoglobulin-polysaccharide nanoparticles for hydrophobic bioactive compounds
KR101529061B1 (ko) 2008-05-30 2015-06-16 모멘타 파머슈티컬스 인코포레이티드 당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
WO2010117803A2 (en) * 2009-03-30 2010-10-14 University Of Georgia Research Foundation, Inc. Heparan sulfate synthesis
US9060932B2 (en) 2009-07-09 2015-06-23 Oshadi Drug Administration Ltd. Matrix carrier compositions, methods and uses
US8288515B2 (en) * 2009-07-31 2012-10-16 Reliable Biopharmaceutical Corporation Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
FR2949114B1 (fr) 2009-08-14 2011-08-26 Sanofi Aventis OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2949115B1 (fr) 2009-08-14 2012-11-02 Sanofi Aventis OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
JP2013537181A (ja) 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
US9005664B2 (en) 2010-10-17 2015-04-14 Technion Research And Development Foundation Ltd. Denatured lactoglobulin and polyphenol coassemblies
FR2970969B1 (fr) 2011-01-27 2013-10-18 Sanofi Aventis Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260933A (en) * 1993-07-16 1996-07-26 Hercules Inc Cation-complexed polysaccharides; use in foods and pharmaceuticals
FR2749849B1 (fr) * 1996-06-14 1998-09-04 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
CZ427499A3 (cs) * 1998-05-29 2000-05-17 The Procter & Gamble Company Jemné topické antimikrobiální přípravky

Also Published As

Publication number Publication date
NO329903B1 (no) 2011-01-24
CA2317465C (en) 2008-05-20
JP2002509164A (ja) 2002-03-26
FR2773804B1 (fr) 2000-02-18
HRP20000480A2 (en) 2000-12-31
CN1165550C (zh) 2004-09-08
ATE209219T1 (de) 2001-12-15
ES2168000T3 (es) 2002-05-16
IL137241A0 (en) 2001-07-24
KR100513196B1 (ko) 2005-09-07
HK1030002A1 (en) 2001-04-20
SK10782000A3 (sk) 2001-02-12
EE04157B1 (et) 2003-10-15
CZ20002635A3 (cs) 2000-12-13
KR20010034189A (ko) 2001-04-25
MY119090A (en) 2005-03-31
MA26597A1 (fr) 2004-12-20
NO20003662D0 (no) 2000-07-17
DZ2709A1 (fr) 2003-09-01
CA2317465A1 (en) 1999-07-22
BR9907025B1 (pt) 2013-12-10
HRP20000480B1 (en) 2002-04-30
TW548279B (en) 2003-08-21
EP1049721B1 (fr) 2001-11-21
ZA99355B (en) 2000-10-11
HUP0102009A1 (hu) 2001-11-28
AU741748B2 (en) 2001-12-06
SK283411B6 (sk) 2003-07-01
UY25356A1 (es) 2000-10-31
SA99191113B1 (ar) 2006-10-11
EG23982A (en) 2008-02-27
AU1974599A (en) 1999-08-02
EE200000429A (et) 2001-12-17
CO4970795A1 (es) 2000-11-07
RU2211224C2 (ru) 2003-08-27
DE69900718T2 (de) 2002-08-22
TR200002078T2 (tr) 2000-11-21
DE69900718D1 (de) 2002-02-21
BRPI9907025B8 (pt) 2016-09-13
EP1049721A1 (fr) 2000-11-08
CZ297815B6 (cs) 2007-04-04
SI1049721T1 (en) 2002-06-30
BR9907025A (pt) 2000-10-17
NO20003662L (no) 2000-09-14
PT1049721E (pt) 2002-05-31
PE20000269A1 (es) 2000-06-15
CN1288470A (zh) 2001-03-21
HU228333B1 (en) 2013-03-28
US6528497B1 (en) 2003-03-04
JP4402835B2 (ja) 2010-01-20
HUP0102009A3 (en) 2003-07-28
DK1049721T3 (da) 2002-04-02
NZ505492A (en) 2001-12-21
PL202802B1 (pl) 2009-07-31
EE200000429A1 (et) 2003-06-16
FR2773804A1 (fr) 1999-07-23
PL341875A1 (en) 2001-05-07
AR013019A1 (es) 2000-11-22
UA60352C2 (uk) 2003-10-15
WO1999036443A1 (fr) 1999-07-22

Similar Documents

Publication Publication Date Title
GT199900003A (es) Polisacaridos de sintesis, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
ES2079589T3 (es) Agentes farmaceuticos.
ES2110003T3 (es) Nuevas composiciones a base de derivados de la clase de los taxanos.
ECSP055531A (es) "nuevos derivados de glicósido de tiofeno, metodos para la preparacion de los mismos, medicamentos que comprenden dichos compuestos, y su uso"
NO20030744D0 (no) Nye fenylalaninderivater
AR021844A1 (es) Derivados de propanolamina aril-sustituidos, procedimientos para su preparacion, medicamentos que contienen estos compuestos y su utilizacion
BR9811478A (pt) Composições de polìmero-ácido tânico para a liberação controlada de agentes farmacêuticos particularmente na cavidade oral
FR2766176B1 (fr) Compositions a base de derives de resveratrol
DE60033684D1 (de) Phenylalaninderivate
ES2177022T3 (es) Un itraconazol que exhibe una solubilidad mejorada, un metodo para preparar el mismo y una composicion farmaceutica para administracion oral que comprende el mismo.
ES2144239T3 (es) Derivados de vitamina d con sustituyentes en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos.
AR021843A1 (es) Derivados de propanolamina sustituidos con heterociclos, procedimiento para su preparacion, y su utilizacion.
ES2163896T3 (es) Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos.
IT1296689B1 (it) Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
ES2062137T3 (es) Utilizacion de 5'-deoxi-5'-metil-tioadenosina, s-adenosilmetionina y sus sales para la preparacion de composiciones farmaceuticas reductoras de seborrea.
BR0114814A (pt) Composições compreendendo composto de modafinila e seu uso
ES2160308T3 (es) Nuevos derivados amino-metil-heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ITMI940989A0 (it) Derivati di acidi ammino-solfonici , loro impiego nella sintesi di pseudopeptidi e procedimento per la loro preparazione
ES2193248T3 (es) Antraquinonas mono- y disulfosustituidas y su uso para el tratamiento de desordenes de la matriz osea.
PT1275647E (pt) Derivados de octa-hidro-2h-pirido¬1,2-a|pirazina processo para a sua preparacao e as composicoes farmaceuticas que os contem
BR0111055A (pt) Formulação farmacêutica, e, processo para a preparação e uso da mesma
DE69813263D1 (de) Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte
AR028015A1 (es) Composiciones cosmeticas para el cuidado de la piel que contienen retinil-ester de alta performance
PA8558501A1 (es) 1,3-diarilprop-2-en1-onas, composiciones que las contienen y su utilizacion