GR871027B - Production and use of il -6 - Google Patents

Production and use of il -6

Info

Publication number
GR871027B
GR871027B GR871027A GR870101027A GR871027B GR 871027 B GR871027 B GR 871027B GR 871027 A GR871027 A GR 871027A GR 870101027 A GR870101027 A GR 870101027A GR 871027 B GR871027 B GR 871027B
Authority
GR
Greece
Prior art keywords
production
hematopoietins
deficiencies
peptide
useful
Prior art date
Application number
GR871027A
Other languages
English (en)
Inventor
Steven C Clark
Gordon G Wong
Paul Schendel
Johhn Mccoy
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR871027(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of GR871027B publication Critical patent/GR871027B/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5412IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/204IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/217IFN-gamma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
GR871027A 1986-07-08 1987-06-30 Production and use of il -6 GR871027B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88320786A 1986-07-08 1986-07-08
US88590586A 1986-07-15 1986-07-15
US4795787A 1987-05-08 1987-05-08

Publications (1)

Publication Number Publication Date
GR871027B true GR871027B (en) 1987-11-02

Family

ID=27367237

Family Applications (1)

Application Number Title Priority Date Filing Date
GR871027A GR871027B (en) 1986-07-08 1987-06-30 Production and use of il -6

Country Status (18)

Country Link
EP (2) EP0316319B1 (el)
JP (1) JP2664698B2 (el)
KR (1) KR960013601B1 (el)
AT (2) ATE124959T1 (el)
AU (1) AU615630B2 (el)
CA (1) CA1341355C (el)
DE (2) DE3751922T2 (el)
DK (1) DK173279B1 (el)
ES (1) ES2006776A6 (el)
GR (1) GR871027B (el)
IE (1) IE67035B1 (el)
IL (1) IL83137A (el)
MY (1) MY102865A (el)
NO (1) NO176665C (el)
PL (1) PL159182B1 (el)
PT (1) PT85285B (el)
SK (1) SK515087A3 (el)
WO (1) WO1988000206A1 (el)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
EP0835661B1 (en) * 1985-10-14 2007-08-29 Yeda Research And Development Co. Ltd. Human interferon-Beta2A for use as a medicament
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β2A及びヒトインターフエロン−β2B、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
JPS6356291A (ja) * 1986-08-27 1988-03-10 Chuzo Kishimoto リコンビナントbcdf
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトb細胞分化因子の遺伝子
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
CA1341588C (en) * 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
IL85204A0 (en) * 1988-01-26 1988-07-31 Yeda Res & Dev Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
JPH022353A (ja) * 1988-03-10 1990-01-08 Tosoh Corp ヒトb細胞分化因子の製造法
JPH022354A (ja) * 1988-03-31 1990-01-08 Tosoh Corp ヒトb細胞分化因子の製造法
GB2217327B (en) * 1988-04-12 1992-01-29 British Bio Technology Synthetic interleukin-6 gene
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5271931A (en) * 1988-09-14 1993-12-21 The Scripps Research Institute Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤
JPH0331215A (ja) * 1989-06-27 1991-02-12 Ajinomoto Co Inc 制癌療法支持剤
DE3939706C1 (el) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
DE69122764T2 (de) * 1990-08-31 1997-03-20 Santen Pharmaceutical Co Ltd Arznei gegen hornhautbeschädigungen
CA2085744A1 (en) * 1991-04-18 1992-10-19 Shingou Sakurai Interleukin-6 compositions, and a production process thereof
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
ZA924674B (en) * 1991-07-02 1993-04-28 Imclone Systems Inc Cysteine depleted il-6 mutein
US5338833A (en) * 1992-07-23 1994-08-16 The University Of North Carolina At Chapel Hill Carboxy terminal IL-6 muteins
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
WO1994028919A1 (en) * 1993-06-08 1994-12-22 Ajinomoto Co., Inc. Hematopoietic cell proliferation accelerator
US5599536A (en) * 1993-12-13 1997-02-04 Sandoz Ltd. Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5578301A (en) * 1993-12-14 1996-11-26 Sandoz Ltd. Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
EP0721780A3 (en) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent for promoting platelet and/or leukocyte production
EP0912742A1 (en) 1996-07-19 1999-05-06 Dade Behring Marburg GmbH Viral interleukin-6
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7479540B1 (en) 2003-12-22 2009-01-20 Chandan Prasad Adipomodulin and related molecules and methods
WO2006086822A1 (en) * 2005-02-15 2006-08-24 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
ES2302402B1 (es) * 2005-06-16 2009-05-08 Proyecto De Biomedicina Cima, S.L. Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
EP0835661B1 (en) * 1985-10-14 2007-08-29 Yeda Research And Development Co. Ltd. Human interferon-Beta2A for use as a medicament
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor

Also Published As

Publication number Publication date
ATE143811T1 (de) 1996-10-15
ATE124959T1 (de) 1995-07-15
DK121788D0 (da) 1988-03-07
PL159182B1 (pl) 1992-11-30
NO176665C (no) 1995-05-10
DK121788A (da) 1988-03-07
MY102865A (en) 1993-03-31
NO880929D0 (no) 1988-03-02
PT85285A (en) 1987-08-01
NO176665B (no) 1995-01-30
IL83137A (en) 1995-05-26
JP2664698B2 (ja) 1997-10-15
EP0316319A1 (en) 1989-05-24
KR880701736A (ko) 1988-11-04
ES2006776A6 (es) 1989-05-16
PL266680A1 (en) 1988-07-07
PT85285B (pt) 1990-03-30
EP0316319B1 (en) 1995-07-12
DE3751406T2 (de) 1995-12-21
DK173279B1 (da) 2000-06-05
SK279144B6 (sk) 1998-07-08
KR960013601B1 (ko) 1996-10-09
IE67035B1 (en) 1996-02-21
EP0574955A1 (en) 1993-12-22
DE3751922D1 (de) 1996-11-14
WO1988000206A1 (en) 1988-01-14
JPH01503354A (ja) 1989-11-16
AU7696287A (en) 1988-01-29
CA1341355C (en) 2002-04-09
NO880929L (no) 1988-03-02
DE3751406D1 (de) 1995-08-17
DE3751922T2 (de) 1997-04-03
EP0574955B1 (en) 1996-10-09
SK515087A3 (en) 1998-07-08
EP0316319A4 (en) 1989-08-09
IE871726L (en) 1988-01-08
AU615630B2 (en) 1991-10-10

Similar Documents

Publication Publication Date Title
GR871027B (en) Production and use of il -6
ZA841597B (en) Human nerve growth factor by recombinant technology
GEP20033145B (en) Stem Cell Factor
GR3033630T3 (en) Gene expression elements and the production of chimeric mouse-human antibodies.
AU2881389A (en) Human ifn-beta 2/il-6, its purification and use
GR3025718T3 (en) Progenitor b cell stimulating factor.
BG60238B1 (bg) Човешки тумор- некротизиращ фактор
NZ218247A (en) Hybrid plasmid for use in producing human lysozyme and the protein so produced
PT86205A (en) Process for the preparation of 3-]omega-(3,5-di-t-butil-4-hydroxyphenyl)-alkanoyl"pyrroles and their de-oxy analogs useful in therapy
IL90719A0 (en) Novel nuclei acids and polypeptides encoded thereby
ZA857721B (en) Process for treatment of rheumatic diseases
CA2004202A1 (en) Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
EP0278715A3 (en) Use of human gamma interferon for treatment of basal cell carcinoma
AU100583S (en) Aquarium-birdcage combination
AU98542S (en) Bat
SU1475058A1 (ru) Днище гидросамолета
GB2214913B (en) Production of vincamine and epivincamine by cell cultures of vinca minor
AU88493S (en) Seat
AU91614S (en) Rangehood canopy
AU99794S (en) Sideboard fastener
AU101295S (en) Sideboard fastener
AU101294S (en) Sideboard fastener
AU102453S (en) Clamp
AU94081S (en) Twist top stubby opener/holder
AU99526S (en) Tap washer