GR75395B - - Google Patents
Info
- Publication number
- GR75395B GR75395B GR66518A GR810166518A GR75395B GR 75395 B GR75395 B GR 75395B GR 66518 A GR66518 A GR 66518A GR 810166518 A GR810166518 A GR 810166518A GR 75395 B GR75395 B GR 75395B
- Authority
- GR
- Greece
- Prior art keywords
- enantiomer
- chem
- pharmaceutically
- compound
- formula
- Prior art date
Links
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Hydrogenated Pyridines (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20649880A | 1980-11-14 | 1980-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR75395B true GR75395B (enEXAMPLES) | 1984-07-13 |
Family
ID=22766667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR66518A GR75395B (enEXAMPLES) | 1980-11-14 | 1981-11-12 |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0052492B1 (enEXAMPLES) |
| JP (3) | JPS57114555A (enEXAMPLES) |
| KR (1) | KR830007508A (enEXAMPLES) |
| AT (1) | ATE6422T1 (enEXAMPLES) |
| AU (1) | AU540707B2 (enEXAMPLES) |
| CA (1) | CA1181430A (enEXAMPLES) |
| CS (1) | CS227019B2 (enEXAMPLES) |
| CY (1) | CY1350A (enEXAMPLES) |
| DD (1) | DD201139A5 (enEXAMPLES) |
| DE (1) | DE3162445D1 (enEXAMPLES) |
| DK (1) | DK161887C (enEXAMPLES) |
| EG (1) | EG15458A (enEXAMPLES) |
| ES (1) | ES8206440A1 (enEXAMPLES) |
| FI (1) | FI77018C (enEXAMPLES) |
| GB (1) | GB2087883A (enEXAMPLES) |
| GR (1) | GR75395B (enEXAMPLES) |
| HK (1) | HK16087A (enEXAMPLES) |
| HU (1) | HU185475B (enEXAMPLES) |
| IE (1) | IE52170B1 (enEXAMPLES) |
| IL (1) | IL64288A (enEXAMPLES) |
| MY (1) | MY8700709A (enEXAMPLES) |
| NZ (1) | NZ198953A (enEXAMPLES) |
| PH (1) | PH17424A (enEXAMPLES) |
| PL (1) | PL233786A1 (enEXAMPLES) |
| PT (1) | PT73982B (enEXAMPLES) |
| RO (1) | RO83309B (enEXAMPLES) |
| SU (1) | SU1068034A3 (enEXAMPLES) |
| ZA (1) | ZA817863B (enEXAMPLES) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777291A (en) * | 1985-02-27 | 1988-10-11 | Eli Lilly And Company | Racemization process |
| US4797286A (en) * | 1985-11-12 | 1989-01-10 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulations |
| US5112619A (en) * | 1985-11-12 | 1992-05-12 | Eli Lilly And Company | Orally administerable sustained release pharmaceutical formulation |
| GB8823405D0 (en) * | 1988-10-05 | 1988-11-09 | Erba Carlo Spa | Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines |
| DK258389D0 (da) * | 1989-05-26 | 1989-05-26 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| ZA921292B (en) * | 1991-02-25 | 1993-08-23 | Lilly Co Eli | Treatment of lower urinary tract disorders. |
| WO1993000074A1 (en) * | 1991-06-26 | 1993-01-07 | Sepracor, Inc. | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
| ES2197144T3 (es) * | 1991-11-15 | 2004-01-01 | Sepracor Inc. | Uso del isomero s(+) puro de fluoxetina para la preparacion de un medicamento contra la migraña. |
| JPH07501547A (ja) * | 1991-11-26 | 1995-02-16 | セプラコア，インコーポレーテッド | 光学的に純粋な（−）アムロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物 |
| EP0576766A1 (en) * | 1992-06-29 | 1994-01-05 | Novo Nordisk A/S | Propanolamine derivatives, their preparation and use |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US6548082B1 (en) | 1999-03-01 | 2003-04-15 | Sepracor Inc. | Methods for treating apnea and apnea disorders using optically pure R(+) ondansetron |
| AU3219800A (en) * | 1999-03-29 | 2000-10-16 | Eli Lilly And Company | Stereospecific method for preparing tomoxetine and intermediates thereof |
| AU3877500A (en) | 1999-04-09 | 2000-11-14 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
| DE19955190A1 (de) * | 1999-11-16 | 2001-06-21 | Sanol Arznei Schwarz Gmbh | Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| EP2316469A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| GB0229583D0 (en) | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US8545881B2 (en) | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| ATE407111T1 (de) | 2004-06-28 | 2008-09-15 | Teva Pharm Fine Chemicals Srl | Isolierte atomoxetinverunreinigung, verfahren zur herstellung von atomoxetinverunreinigungen und deren verwendung als referenzstandards |
| US7439399B2 (en) * | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
| US7473804B2 (en) | 2004-07-22 | 2009-01-06 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| US20060105039A1 (en) | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| EP1889828A1 (en) * | 2005-04-05 | 2008-02-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
| EP1751085A1 (en) * | 2005-04-05 | 2007-02-14 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US7485754B2 (en) | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
| CZ296345B6 (cs) * | 2005-07-21 | 2006-02-15 | Zentiva, A. S | Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu) |
| EP1798215A1 (en) | 2005-12-14 | 2007-06-20 | SOLMAG S.p.A. | Polymorph of atomoxetine hydrochloride in crystalline form |
| ITMI20061987A1 (it) * | 2006-10-16 | 2008-04-17 | Archimica Srl | Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine. |
| WO2008062473A1 (en) * | 2006-10-31 | 2008-05-29 | Cadila Healthcare Limited | Process for preparing atomoxetine hydrochloride |
| CN100430370C (zh) * | 2006-11-03 | 2008-11-05 | 华东理工大学 | 一种丙胺衍生物及其在制备托莫西汀中的应用 |
| WO2009141833A2 (en) * | 2008-04-17 | 2009-11-26 | Ind-Swift Laboratories Limited | An improved process for synthesizing highly pure atomoxetine |
| ES2668203T3 (es) | 2009-12-02 | 2018-05-17 | Adare Pharmaceuticals S.R.L. | Microcápsulas de fexofenadina y composiciones que las contienen |
| SI2838510T1 (sl) | 2013-11-08 | 2016-11-30 | Eli Lilly And Company Lilly Corporate Center | Raztopina atomoksetina |
| GR1008531B (el) | 2014-03-21 | 2015-07-13 | Λαμδα Φαρμακευτικα Εργαστηρια Εφαμροσμενης Ερευνας Και Αναπτυξης Α.Ε., | Ποσιμα διαλυματα που περιεχουν υδροχλωρικη ατομοξετινη |
| EP3069715A1 (en) | 2015-03-20 | 2016-09-21 | Salmon Pharma GmbH | Immediate release dosage forms of Atomoxetine |
| CN106916074A (zh) * | 2017-02-14 | 2017-07-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
| CN110294680A (zh) * | 2018-03-22 | 2019-10-01 | 北京深蓝海生物医药科技有限公司 | 一种盐酸阿托莫西汀的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| US4194009A (en) * | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| JPS5283811A (en) * | 1976-01-01 | 1977-07-13 | Lilly Co Eli | Aryloxy phenyl propylamines and their salts |
| GB1596033A (en) * | 1978-04-25 | 1981-08-19 | Boots Co Ltd | (-)-(2-methoxyphenyl) ethylamine |
| JPS5536403A (en) * | 1978-07-28 | 1980-03-14 | Nippon Iyakuhin Kogyo Kk | Preparation of 1-benzazonine derivative |
| IT1113029B (it) * | 1979-03-01 | 1986-01-20 | Simes | Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro |
-
1981
- 1981-11-12 PT PT73982A patent/PT73982B/pt not_active IP Right Cessation
- 1981-11-12 NZ NZ198953A patent/NZ198953A/en unknown
- 1981-11-12 RO RO105785A patent/RO83309B/ro unknown
- 1981-11-12 ZA ZA817863A patent/ZA817863B/xx unknown
- 1981-11-12 GR GR66518A patent/GR75395B/el unknown
- 1981-11-12 FI FI813589A patent/FI77018C/fi not_active IP Right Cessation
- 1981-11-12 PL PL23378681A patent/PL233786A1/xx unknown
- 1981-11-12 CA CA000389954A patent/CA1181430A/en not_active Expired
- 1981-11-12 AU AU77427/81A patent/AU540707B2/en not_active Ceased
- 1981-11-13 JP JP56182953A patent/JPS57114555A/ja active Granted
- 1981-11-13 SU SU813355735A patent/SU1068034A3/ru active
- 1981-11-13 HU HU813411A patent/HU185475B/hu not_active IP Right Cessation
- 1981-11-13 GB GB8134282A patent/GB2087883A/en active Pending
- 1981-11-13 CS CS818359A patent/CS227019B2/cs unknown
- 1981-11-13 DD DD81234837A patent/DD201139A5/de not_active IP Right Cessation
- 1981-11-13 ES ES507142A patent/ES8206440A1/es not_active Expired
- 1981-11-13 AT AT81305387T patent/ATE6422T1/de not_active IP Right Cessation
- 1981-11-13 EP EP81305387A patent/EP0052492B1/en not_active Expired
- 1981-11-13 DK DK502781A patent/DK161887C/da active
- 1981-11-13 DE DE8181305387T patent/DE3162445D1/de not_active Expired
- 1981-11-13 IE IE2661/81A patent/IE52170B1/en not_active IP Right Cessation
- 1981-11-13 PH PH26491A patent/PH17424A/en unknown
- 1981-11-13 CY CY135081A patent/CY1350A/xx unknown
- 1981-11-14 EG EG662/81A patent/EG15458A/xx active
- 1981-11-14 KR KR1019810004404A patent/KR830007508A/ko not_active Ceased
- 1981-11-15 IL IL64288A patent/IL64288A/xx not_active IP Right Cessation
-
1987
- 1987-02-19 HK HK160/87A patent/HK16087A/en not_active IP Right Cessation
- 1987-12-30 MY MY709/87A patent/MY8700709A/xx unknown
-
1990
- 1990-06-05 JP JP2147167A patent/JPH037251A/ja active Granted
- 1990-06-05 JP JP2147166A patent/JPH037250A/ja active Granted
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