AU3219800A - Stereospecific method for preparing tomoxetine and intermediates thereof - Google Patents
Stereospecific method for preparing tomoxetine and intermediates thereofInfo
- Publication number
- AU3219800A AU3219800A AU32198/00A AU3219800A AU3219800A AU 3219800 A AU3219800 A AU 3219800A AU 32198/00 A AU32198/00 A AU 32198/00A AU 3219800 A AU3219800 A AU 3219800A AU 3219800 A AU3219800 A AU 3219800A
- Authority
- AU
- Australia
- Prior art keywords
- intermediates
- stereospecific method
- tomoxetine
- preparing
- preparing tomoxetine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12670199P | 1999-03-29 | 1999-03-29 | |
US60126701 | 1999-03-29 | ||
PCT/US2000/002527 WO2000058262A1 (en) | 1999-03-29 | 2000-02-29 | Stereospecific method for preparing tomoxetine and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU3219800A true AU3219800A (en) | 2000-10-16 |
Family
ID=22426257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU32198/00A Abandoned AU3219800A (en) | 1999-03-29 | 2000-02-29 | Stereospecific method for preparing tomoxetine and intermediates thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU3219800A (en) |
WO (1) | WO2000058262A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200705146T1 (en) | 2001-03-06 | 2008-02-21 | Eli Lilly And Company | Inhibition of Monoamine Elevation |
WO2006004977A2 (en) | 2004-06-28 | 2006-01-12 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for the optical resolution and recycling of tomoxetine |
US7439399B2 (en) | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
CN1976894A (en) | 2004-07-22 | 2007-06-06 | 特瓦药物精化学品股份有限公司 | Polymorphs of atomoxetine hydrochloride |
EP1751085A1 (en) * | 2005-04-05 | 2007-02-14 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
US7485754B2 (en) | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
WO2008026227A2 (en) * | 2006-08-28 | 2008-03-06 | Matrix Laboratories Ltd | A process for the preparation of atomoxetine hydrochloride |
ITMI20061987A1 (en) | 2006-10-16 | 2008-04-17 | Archimica Srl | PROCESS FOR THE SYNTHESIS OF ARYLOSSIPROPYLAMINES AND HETERARYLOSOSIPROPYLAMINES. |
CN106187788A (en) * | 2016-07-29 | 2016-12-07 | 北京万全德众医药生物技术有限公司 | A kind of preparation method of tomoxetine hydrochloride |
CN113219094A (en) * | 2021-05-07 | 2021-08-06 | 湖北欣泽霏药业有限公司 | Liquid chromatography detection method for optical isomer of tomoxetine hydrochloride oral solution |
CN113358773B (en) * | 2021-05-21 | 2022-09-13 | 健民药业集团股份有限公司 | Reversed phase liquid chromatography method for detecting atomoxetine hydrochloride enantiomer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
NZ198953A (en) * | 1980-11-14 | 1984-10-19 | Lilly Co Eli | (-)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine,its salts and pharmaceutical formulations |
US4777291A (en) * | 1985-02-27 | 1988-10-11 | Eli Lilly And Company | Racemization process |
DK630987D0 (en) * | 1987-12-01 | 1987-12-01 | Ferrosan As | ARYLOXYPHENYL PROPYLAMINES, THEIR PREPARATION AND USE |
-
2000
- 2000-02-29 AU AU32198/00A patent/AU3219800A/en not_active Abandoned
- 2000-02-29 WO PCT/US2000/002527 patent/WO2000058262A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2000058262A1 (en) | 2000-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |