IL64288A0 - Improvements relating to 3-aryloxy-3-phenylpropylamines - Google Patents

Improvements relating to 3-aryloxy-3-phenylpropylamines

Info

Publication number
IL64288A0
IL64288A0 IL64288A IL6428881A IL64288A0 IL 64288 A0 IL64288 A0 IL 64288A0 IL 64288 A IL64288 A IL 64288A IL 6428881 A IL6428881 A IL 6428881A IL 64288 A0 IL64288 A0 IL 64288A0
Authority
IL
Israel
Prior art keywords
phenylpropylamines
aryloxy
improvements relating
enantiomer
chem
Prior art date
Application number
IL64288A
Other versions
IL64288A (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL64288A0 publication Critical patent/IL64288A0/en
Publication of IL64288A publication Critical patent/IL64288A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

The (-)-enantiomer of the compound of formula (I): <CHEM> and its pharmaceutically-acceptable salts, are effective anti-depressant agents.
IL64288A 1980-11-14 1981-11-15 (-)-enantiomer of n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine and salts,its preparation and pharmaceutical compositions comprising them IL64288A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20649880A 1980-11-14 1980-11-14

Publications (2)

Publication Number Publication Date
IL64288A0 true IL64288A0 (en) 1982-02-28
IL64288A IL64288A (en) 1985-04-30

Family

ID=22766667

Family Applications (1)

Application Number Title Priority Date Filing Date
IL64288A IL64288A (en) 1980-11-14 1981-11-15 (-)-enantiomer of n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine and salts,its preparation and pharmaceutical compositions comprising them

Country Status (28)

Country Link
EP (1) EP0052492B1 (en)
JP (3) JPS57114555A (en)
KR (1) KR830007508A (en)
AT (1) ATE6422T1 (en)
AU (1) AU540707B2 (en)
CA (1) CA1181430A (en)
CS (1) CS227019B2 (en)
CY (1) CY1350A (en)
DD (1) DD201139A5 (en)
DE (1) DE3162445D1 (en)
DK (1) DK161887C (en)
EG (1) EG15458A (en)
ES (1) ES8206440A1 (en)
FI (1) FI77018C (en)
GB (1) GB2087883A (en)
GR (1) GR75395B (en)
HK (1) HK16087A (en)
HU (1) HU185475B (en)
IE (1) IE52170B1 (en)
IL (1) IL64288A (en)
MY (1) MY8700709A (en)
NZ (1) NZ198953A (en)
PH (1) PH17424A (en)
PL (1) PL233786A1 (en)
PT (1) PT73982B (en)
RO (1) RO83309B (en)
SU (1) SU1068034A3 (en)
ZA (1) ZA817863B (en)

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US4777291A (en) * 1985-02-27 1988-10-11 Eli Lilly And Company Racemization process
US4797286A (en) * 1985-11-12 1989-01-10 Eli Lilly And Company Orally administerable sustained release pharmaceutical formulations
US5112619A (en) * 1985-11-12 1992-05-12 Eli Lilly And Company Orally administerable sustained release pharmaceutical formulation
GB8823405D0 (en) * 1988-10-05 1988-11-09 Erba Carlo Spa Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines
DK258389D0 (en) * 1989-05-26 1989-05-26 Ferrosan As ARYLOXYPHENYL PROPYLAMINES, THEIR PREPARATION AND USE
AU642582B2 (en) * 1991-02-25 1993-10-21 Eli Lilly And Company Treatment of lower urinary tract disorders
EP0591434A4 (en) * 1991-06-26 1994-09-14 Sepracor Inc Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
DK0612242T3 (en) * 1991-11-15 2003-10-20 Sepracor Inc Use of pure S (+) - isomer of fluoxetine to produce a drug for migraine
CA2124445A1 (en) * 1991-11-26 1993-06-10 James W. Young Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
EP0576766A1 (en) * 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
TW344661B (en) * 1993-11-24 1998-11-11 Lilly Co Eli Pharmaceutical composition for treatment of incontinence
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
JP2002538102A (en) 1999-03-01 2002-11-12 セプラコア インコーポレーテッド Method of treating apnea and apnea disorder using optically pure R (+) ondansetron
AU3219800A (en) * 1999-03-29 2000-10-16 Eli Lilly And Company Stereospecific method for preparing tomoxetine and intermediates thereof
DE60023870T2 (en) 1999-04-09 2006-06-14 Lilly Co Eli PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-ARYLPROPYLAMINE AND THEIR INTERMEDIATE PRODUCTS
DE19955190A1 (en) * 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stable salts of novel derivatives of 3,3-diphenylpropylamines
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
GB0229583D0 (en) 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US8545881B2 (en) 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
US7507861B2 (en) * 2004-06-28 2009-03-24 Teva Pharmaceutical Fine Chemicals, S.R.L. Process for the preparation of atomoxetine hydrochloride
US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
CA2568629A1 (en) * 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of atomoxetine hydrochloride
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
EP1889828A1 (en) * 2005-04-05 2008-02-20 Teva Pharmaceutical Fine Chemicals S.R.L. Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US7569729B2 (en) * 2005-04-05 2009-08-04 Teva Pharmaceutical Fine Chemicals S.R.L. Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US7485754B2 (en) 2005-07-08 2009-02-03 Apotex Pharmachem Inc. Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
CZ296345B6 (en) * 2005-07-21 2006-02-15 Zentiva, A. S Process for preparing (R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride (atomoxetine)
EP1798215A1 (en) * 2005-12-14 2007-06-20 SOLMAG S.p.A. Polymorph of atomoxetine hydrochloride in crystalline form
ITMI20061987A1 (en) * 2006-10-16 2008-04-17 Archimica Srl PROCESS FOR THE SYNTHESIS OF ARYLOSSIPROPYLAMINES AND HETERARYLOSOSIPROPYLAMINES.
WO2008062473A1 (en) * 2006-10-31 2008-05-29 Cadila Healthcare Limited Process for preparing atomoxetine hydrochloride
CN100430370C (en) * 2006-11-03 2008-11-05 华东理工大学 Propylamine derivative and its application in preparing tomocetin
WO2009141833A2 (en) * 2008-04-17 2009-11-26 Ind-Swift Laboratories Limited An improved process for synthesizing highly pure atomoxetine
JP5309262B2 (en) 2009-12-02 2013-10-09 アプタリス ファーマ リミテッド Fexofenadine microcapsule and composition containing the same
CN105705135A (en) * 2013-11-08 2016-06-22 伊莱利利公司 Atomoxetine solution
GR1008531B (en) 2014-03-21 2015-07-13 Λαμδα Φαρμακευτικα Εργαστηρια Εφαμροσμενης Ερευνας Και Αναπτυξης Α.Ε., Oral solution comprising atomoxetine hydrochloride
EP3069715A1 (en) 2015-03-20 2016-09-21 Salmon Pharma GmbH Immediate release dosage forms of Atomoxetine
CN106916074A (en) * 2017-02-14 2017-07-04 万特制药(海南)有限公司 The preparation of tomoxetine hydrochloride
CN110294680A (en) * 2018-03-22 2019-10-01 北京深蓝海生物医药科技有限公司 A kind of preparation method in levels Moses spit of fland

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194009A (en) * 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
JPS5283811A (en) * 1976-01-01 1977-07-13 Lilly Co Eli Aryloxy phenyl propylamines and their salts
GB1596033A (en) * 1978-04-25 1981-08-19 Boots Co Ltd (-)-(2-methoxyphenyl) ethylamine
JPS5536403A (en) * 1978-07-28 1980-03-14 Nippon Iyakuhin Kogyo Kk Preparation of 1-benzazonine derivative
IT1113029B (en) * 1979-03-01 1986-01-20 Simes PROCESS FOR THE SEPARATION OF THE TWO OPTICAL ISOMERS OF MOPROLOL AND PHARMACEUTICAL COMPOSITIONS OF THE LEVOGIRO ANTIPOD

Also Published As

Publication number Publication date
ES507142A0 (en) 1982-08-16
IE812661L (en) 1982-05-14
KR830007508A (en) 1983-10-21
PH17424A (en) 1984-08-08
DD201139A5 (en) 1983-07-06
PL233786A1 (en) 1982-05-24
RO83309A (en) 1984-02-21
FI77018C (en) 1989-01-10
JPH0369885B2 (en) 1991-11-05
GB2087883A (en) 1982-06-03
NZ198953A (en) 1984-10-19
ATE6422T1 (en) 1984-03-15
JPH046698B2 (en) 1992-02-06
SU1068034A3 (en) 1984-01-15
JPH046699B2 (en) 1992-02-06
EP0052492B1 (en) 1984-02-29
JPS57114555A (en) 1982-07-16
FI77018B (en) 1988-09-30
DK161887B (en) 1991-08-26
JPH037250A (en) 1991-01-14
GR75395B (en) 1984-07-13
ES8206440A1 (en) 1982-08-16
JPH037251A (en) 1991-01-14
DE3162445D1 (en) 1984-04-05
CA1181430A (en) 1985-01-22
MY8700709A (en) 1987-12-31
FI813589L (en) 1982-05-15
EP0052492A1 (en) 1982-05-26
EG15458A (en) 1986-09-30
RO83309B (en) 1984-02-28
IE52170B1 (en) 1987-07-22
PT73982B (en) 1983-11-23
DK161887C (en) 1992-03-16
ZA817863B (en) 1983-06-29
IL64288A (en) 1985-04-30
AU7742781A (en) 1982-05-20
CY1350A (en) 1987-04-24
HK16087A (en) 1987-02-27
DK502781A (en) 1982-05-15
AU540707B2 (en) 1984-11-29
CS227019B2 (en) 1984-04-16
PT73982A (en) 1981-12-01
HU185475B (en) 1985-02-28

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