GR3036636T3 - Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias - Google Patents

Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Info

Publication number
GR3036636T3
GR3036636T3 GR20010401494T GR20010401494T GR3036636T3 GR 3036636 T3 GR3036636 T3 GR 3036636T3 GR 20010401494 T GR20010401494 T GR 20010401494T GR 20010401494 T GR20010401494 T GR 20010401494T GR 3036636 T3 GR3036636 T3 GR 3036636T3
Authority
GR
Greece
Prior art keywords
xanthen
imino
amino
benzoic acid
ester hydrochloride
Prior art date
Application number
GR20010401494T
Other languages
English (en)
Inventor
Louis Gaboury
Richard Giasson
Li Tiechao
Ajay Kumar Gupta
Luc Villeneuve
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of GR3036636T3 publication Critical patent/GR3036636T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Radiation-Therapy Devices (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GR20010401494T 1994-09-02 2001-09-17 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias GR3036636T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/300,179 US5556992A (en) 1994-09-02 1994-09-02 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
PCT/CA1995/000485 WO1996007431A1 (en) 1994-09-02 1995-08-16 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Publications (1)

Publication Number Publication Date
GR3036636T3 true GR3036636T3 (en) 2001-12-31

Family

ID=23158032

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010401494T GR3036636T3 (en) 1994-09-02 2001-09-17 Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Country Status (14)

Country Link
US (2) US5556992A (el)
EP (1) EP0773794B1 (el)
JP (1) JP4222628B2 (el)
KR (1) KR970705413A (el)
AT (1) ATE202286T1 (el)
AU (1) AU688100B2 (el)
BR (1) BR9508779A (el)
CA (1) CA2197435C (el)
DE (1) DE69521430T2 (el)
DK (1) DK0773794T3 (el)
ES (1) ES2160173T3 (el)
GR (1) GR3036636T3 (el)
PT (1) PT773794E (el)
WO (1) WO1996007431A1 (el)

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US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US6331286B1 (en) * 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US7036516B1 (en) 1996-10-30 2006-05-02 Xantech Pharmaceuticals, Inc. Treatment of pigmented tissues using optical energy
JPH10279502A (ja) * 1997-03-31 1998-10-20 Katsuro Tachibana 光感受性物質の励起方法
IL121440A0 (en) 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
US6342611B1 (en) * 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
BR9814816A (pt) * 1997-10-10 2004-06-22 Cytovia Inc Novas moléculas repórter fluorescentes e suas aplicações incluindo análises de caspases
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
WO1999037753A1 (en) * 1998-01-23 1999-07-29 Newbiotics, Inc. Enzyme catalyzed therapeutic agents
WO2000004914A1 (en) * 1998-07-21 2000-02-03 Cytovia, Inc. Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7648695B2 (en) 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US8470296B2 (en) 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
AR022404A1 (es) * 1999-01-25 2002-09-04 Photogen Inc Metodo y agentes para la terapia de radiacion mejorada
US20040228871A1 (en) * 1999-06-03 2004-11-18 Tayyaba Hasan Treatment and analysis of proliferative disorders
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
CA2378187C (en) * 1999-07-22 2011-09-13 Newbiotics, Inc. Methods for treating therapy-resistant tumors
EP2020242B1 (en) * 1999-08-13 2011-10-19 Provectus Pharmatech, Inc. Improved Topical Medicaments and Methods for Photodynamic Treatment of Disease
US8409564B2 (en) * 1999-10-05 2013-04-02 Universite De Montreal Rhodamine derivatives for photodynamic diagnosis and treatment
AU781855B2 (en) * 1999-10-05 2005-06-16 Hopital Maisonneuve-Rosemont Rhodamine derivatives for photodynamic diagnosis and treatment
WO2002012545A2 (en) 2000-08-03 2002-02-14 Cytovia, Inc. Method of identifying immunosuppressive agents
US20020123530A1 (en) * 2001-01-03 2002-09-05 Indig Guilherme Luiz Use of crystal violet as photochemotherapeutic agent
US20040086453A1 (en) * 2001-01-22 2004-05-06 Howes Randolph M. Compositions, methods, apparatuses, and systems for singlet oxygen delivery
BRPI0204489B8 (pt) * 2001-04-02 2021-05-25 Celmed Biosciences Inc "derivado de rodamina, composição farmacêutica, intermediário, e, processo para a síntese de novos derivados rodamina".
CA2342675A1 (en) * 2001-04-02 2002-10-02 Abdelkrim Habi Halogenated rhodamine derivatives and applications thereof
US20030027229A1 (en) * 2001-06-01 2003-02-06 Cytovia, Inc. Methods of identifying potentially therapeutically selective and effective anti-cancer agents that are inducers of apoptosis
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
MXPA06006286A (es) * 2003-12-05 2006-09-04 Univ Montreal Compuestos inmunologicos para prevencion, proteccion, profilaxis o tratamiento de trastornos inmunologicos, infecciones y cancer.
US8198328B2 (en) * 2004-01-21 2012-06-12 New York University Treatment of cancer using benzoic acid derivatives
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
US20100144854A1 (en) * 2007-03-16 2010-06-10 Mikhail Kutushov Use of rhodamine 6g as a medicinal agent for treating malignant neoplasms and amiloidoses
WO2010085651A1 (en) * 2009-01-23 2010-07-29 The Penn State Research Foundation In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles
GB0904825D0 (en) 2009-03-20 2009-05-06 Photobiotics Ltd Biological materials and uses thereof
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
RU2527519C2 (ru) * 2010-06-24 2014-09-10 Общество С Ограниченной Ответственностью "Митотех" Мягкие катионные митохондриальные разобщители
CN102304295A (zh) * 2011-07-12 2012-01-04 核工业理化工程研究院 一种适合532nm激光泵浦的罗丹明101酯激光染料的制备方法
CN103183657A (zh) * 2011-12-31 2013-07-03 中国科学院成都有机化学有限公司 一种罗丹明酯化衍生物的合成方法
EP3058957A1 (en) 2015-02-19 2016-08-24 Kiadis Pharma Intellectual Property BV Improved photodynamic process and product obtained therefrom
CN107118198B (zh) * 2017-06-08 2019-07-09 福州大学 兼有抗癌作用和荧光性能的罗丹明b衍生物及其制备方法
CN107880009A (zh) * 2017-11-28 2018-04-06 西安石油大学 一种具有表面活性的罗丹明b荧光探针制备方法
KR20200083538A (ko) 2017-11-29 2020-07-08 더 락커펠러 유니버시티 피부 병태의 치료 향상을 위한 국부 요법과 전신 요법의 조합
US11474098B2 (en) 2017-12-22 2022-10-18 The Trustees Of Columbia University In The City Of New York Drug target for preventing pathologic calcium overload in cardiomyocytes and methods of screening for same
CN115960090B (zh) * 2022-12-30 2024-03-29 中山大学 一种罗丹明b修饰吡啶配体的制备方法及其光催化抗菌应用

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DE3832739A1 (de) * 1988-09-27 1990-03-29 Basf Ag Verfahren zur herstellung von rhodamin-farbstoffen in granulatform
WO1993000005A1 (en) * 1991-06-21 1993-01-07 Baxter International Inc. Method for inactivating pathogens in a body fluid
US5459268A (en) * 1993-10-25 1995-10-17 Molecular Probes, Inc. Xanthylium dyes that are well retained in mitochondria

Also Published As

Publication number Publication date
AU688100B2 (en) 1998-03-05
ATE202286T1 (de) 2001-07-15
BR9508779A (pt) 1997-12-23
EP0773794B1 (en) 2001-06-20
CA2197435C (en) 2010-01-12
EP0773794A1 (en) 1997-05-21
AU3248895A (en) 1996-03-27
PT773794E (pt) 2001-12-28
DE69521430T2 (de) 2002-05-02
DK0773794T3 (da) 2001-10-15
US5556992A (en) 1996-09-17
KR970705413A (ko) 1997-10-09
WO1996007431A1 (en) 1996-03-14
JPH10505349A (ja) 1998-05-26
DE69521430D1 (de) 2001-07-26
ES2160173T3 (es) 2001-11-01
JP4222628B2 (ja) 2009-02-12
US5773460A (en) 1998-06-30
CA2197435A1 (en) 1996-03-14

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