CA2223522A1 - Use of 5-aminolevulinic acid for treating or detecting rapidly growing cells of exogenous origin - Google Patents
Use of 5-aminolevulinic acid for treating or detecting rapidly growing cells of exogenous originInfo
- Publication number
- CA2223522A1 CA2223522A1 CA002223522A CA2223522A CA2223522A1 CA 2223522 A1 CA2223522 A1 CA 2223522A1 CA 002223522 A CA002223522 A CA 002223522A CA 2223522 A CA2223522 A CA 2223522A CA 2223522 A1 CA2223522 A1 CA 2223522A1
- Authority
- CA
- Canada
- Prior art keywords
- treating
- aminolevulinic acid
- rapidly growing
- growing cells
- exogenous cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002749 aminolevulinic acid Drugs 0.000 title abstract 2
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000002165 photosensitisation Effects 0.000 abstract 1
- 239000003504 photosensitizing agent Substances 0.000 abstract 1
- 150000004032 porphyrins Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 229950003776 protoporphyrin Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluroescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/465,242 US5955490A (en) | 1989-07-28 | 1995-06-05 | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
| US08/465,242 | 1995-06-05 | ||
| PCT/CA1996/000363 WO1996039188A1 (en) | 1995-06-05 | 1996-06-03 | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2223522A1 true CA2223522A1 (en) | 1996-12-12 |
| CA2223522C CA2223522C (en) | 2009-02-10 |
Family
ID=23847002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002223522A Expired - Lifetime CA2223522C (en) | 1995-06-05 | 1996-06-03 | Use of 5-aminolevulinic acid for treating or detecting rapidly growing cells of exogenous origin |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | ATE287709T1 (en) |
| AU (1) | AU5888796A (en) |
| CA (1) | CA2223522C (en) |
| DE (1) | DE69634250T2 (en) |
| DK (1) | DK0831909T3 (en) |
| ES (1) | ES2236731T3 (en) |
-
1996
- 1996-06-03 AU AU58887/96A patent/AU5888796A/en not_active Abandoned
- 1996-06-03 CA CA002223522A patent/CA2223522C/en not_active Expired - Lifetime
- 1996-06-03 AT AT96915923T patent/ATE287709T1/en active
- 1996-06-03 DK DK96915923T patent/DK0831909T3/en active
- 1996-06-03 DE DE69634250T patent/DE69634250T2/en not_active Expired - Lifetime
- 1996-06-03 ES ES96915923T patent/ES2236731T3/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5888796A (en) | 1996-12-24 |
| CA2223522C (en) | 2009-02-10 |
| ES2236731T3 (en) | 2005-07-16 |
| DE69634250T2 (en) | 2006-03-30 |
| DE69634250D1 (en) | 2005-03-03 |
| DK0831909T3 (en) | 2005-06-06 |
| ATE287709T1 (en) | 2005-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160603 |