AU5888796A - Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins - Google Patents

Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins

Info

Publication number
AU5888796A
AU5888796A AU58887/96A AU5888796A AU5888796A AU 5888796 A AU5888796 A AU 5888796A AU 58887/96 A AU58887/96 A AU 58887/96A AU 5888796 A AU5888796 A AU 5888796A AU 5888796 A AU5888796 A AU 5888796A
Authority
AU
Australia
Prior art keywords
aminolevulinic acid
exogenous cells
precursors
endogenous porphyrins
photochemotherapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU58887/96A
Inventor
James C. Kennedy
Roy H. Pottier
Robert L. Reid
Arnold Sac-Morales
Lewis L. Tomalty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queens University at Kingston
Original Assignee
Queens University at Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/465,242 external-priority patent/US5955490A/en
Application filed by Queens University at Kingston filed Critical Queens University at Kingston
Priority claimed from PCT/CA1996/000363 external-priority patent/WO1996039188A1/en
Publication of AU5888796A publication Critical patent/AU5888796A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor there of is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluroescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivati ng wavelengths.
AU58887/96A 1995-06-05 1996-06-03 Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins Abandoned AU5888796A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US465242 1995-06-05
US08/465,242 US5955490A (en) 1989-07-28 1995-06-05 Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
PCT/CA1996/000363 WO1996039188A1 (en) 1995-06-05 1996-06-03 Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins

Publications (1)

Publication Number Publication Date
AU5888796A true AU5888796A (en) 1996-12-24

Family

ID=23847002

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58887/96A Abandoned AU5888796A (en) 1995-06-05 1996-06-03 Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins

Country Status (6)

Country Link
AT (1) ATE287709T1 (en)
AU (1) AU5888796A (en)
CA (1) CA2223522C (en)
DE (1) DE69634250T2 (en)
DK (1) DK0831909T3 (en)
ES (1) ES2236731T3 (en)

Also Published As

Publication number Publication date
CA2223522C (en) 2009-02-10
ES2236731T3 (en) 2005-07-16
CA2223522A1 (en) 1996-12-12
DE69634250T2 (en) 2006-03-30
DE69634250D1 (en) 2005-03-03
DK0831909T3 (en) 2005-06-06
ATE287709T1 (en) 2005-02-15

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