GR3034485T3 - Tricyclic substituted hexahydrobenz e]isoindole alpha-1 adrenergic antagonists - Google Patents
Tricyclic substituted hexahydrobenz e]isoindole alpha-1 adrenergic antagonistsInfo
- Publication number
- GR3034485T3 GR3034485T3 GR20000402174T GR20000402174T GR3034485T3 GR 3034485 T3 GR3034485 T3 GR 3034485T3 GR 20000402174 T GR20000402174 T GR 20000402174T GR 20000402174 T GR20000402174 T GR 20000402174T GR 3034485 T3 GR3034485 T3 GR 3034485T3
- Authority
- GR
- Greece
- Prior art keywords
- alpha
- adrenergic antagonists
- tricyclic substituted
- isoindole
- substituted hexahydrobenz
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37941495A | 1995-01-27 | 1995-01-27 | |
| US08/463,528 US5597823A (en) | 1995-01-27 | 1995-06-05 | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| PCT/US1996/000072 WO1996022992A1 (en) | 1995-01-27 | 1996-01-11 | Tricyclic substituted hexahydrobenz[e]isoindole alpha-1 adrenergic antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3034485T3 true GR3034485T3 (en) | 2000-12-29 |
Family
ID=27008615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000402174T GR3034485T3 (en) | 1995-01-27 | 2000-09-26 | Tricyclic substituted hexahydrobenz e]isoindole alpha-1 adrenergic antagonists |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5597823A (ja) |
| EP (1) | EP0808318B1 (ja) |
| JP (1) | JP2001504797A (ja) |
| KR (1) | KR19980701700A (ja) |
| AT (1) | ATE194141T1 (ja) |
| AU (1) | AU705283B2 (ja) |
| CA (1) | CA2211212A1 (ja) |
| DE (1) | DE69609051T2 (ja) |
| DK (1) | DK0808318T3 (ja) |
| ES (1) | ES2149451T3 (ja) |
| GR (1) | GR3034485T3 (ja) |
| IL (1) | IL116405A (ja) |
| MX (1) | MX9705674A (ja) |
| PT (1) | PT808318E (ja) |
| WO (1) | WO1996022992A1 (ja) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177430B1 (en) | 1997-03-27 | 2001-01-23 | Pfizer Inc | Use of α1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| IL120302A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
| AR008395A1 (es) * | 1996-07-09 | 2000-01-19 | Astra Pharma Prod | Compuesto derivado de pirimidina, composicion farmaceutica que lo comprende, procedimiento para prepararlo, y compuesto intermediario util parallevar a cabo dicho procedimiento. |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
| AU7972698A (en) * | 1997-06-18 | 1999-01-04 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| WO1999048530A1 (en) * | 1998-03-23 | 1999-09-30 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6133275A (en) * | 1998-05-06 | 2000-10-17 | Abbott Laboratories | 3-phenylpyrrolidine alpha-1 adrenergic compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| EP1112743B1 (en) | 1998-08-20 | 2007-10-24 | Toyama Chemical Co., Ltd. | Nitrogenous heterocyclic carboxamide derivatives or salt thereof as antiviral agents |
| EP1115710A1 (en) * | 1998-08-20 | 2001-07-18 | Abbott Laboratories | Process for preparing regiospecific substituted pyrazine isomers |
| ID30516A (id) * | 1998-12-24 | 2001-12-13 | Aventis Pharm Prod Inc | Senyawa-senyawa (aminoiminometil atau aminometil) benzoheteroaril tersubstitusi |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
| US7497827B2 (en) | 2004-07-13 | 2009-03-03 | Dexcom, Inc. | Transcutaneous analyte sensor |
| JP2005104838A (ja) | 2003-01-09 | 2005-04-21 | Tanabe Seiyaku Co Ltd | 縮合フラン化合物 |
| US7524853B2 (en) * | 2003-06-10 | 2009-04-28 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7465739B2 (en) * | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| EP1828197B1 (en) * | 2004-12-13 | 2009-05-13 | Solvay Pharmaceuticals GmbH | NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE |
| EP2336117A1 (en) | 2005-05-26 | 2011-06-22 | Neuron Systems, Inc | Heterocyclic compounds for treating retinal diseases |
| ES2567133T3 (es) * | 2005-06-23 | 2016-04-20 | Array Biopharma, Inc. | Proceso para preparar compuestos de benzoimidazol |
| AU2006311851A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-A2 inhibitors |
| JP5041403B2 (ja) * | 2007-02-02 | 2012-10-03 | 国立大学法人北海道大学 | カフェイン類縁体 |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| SG11201504859YA (en) | 2012-12-20 | 2015-07-30 | Aldeyra Therapeutics Inc | Peri-carbinols |
| SG11201505587YA (en) | 2013-01-23 | 2015-08-28 | Aldeyra Therapeutics Inc | Toxic aldehyde related diseases and treatment |
| WO2014116593A1 (en) | 2013-01-25 | 2014-07-31 | Aldexa Therapeutics, Inc. | Novel traps in the treatment of macular degeneration |
| EP4400106A1 (en) | 2015-08-21 | 2024-07-17 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| ES2968462T3 (es) | 2017-03-16 | 2024-05-09 | Aldeyra Therapeutics Inc | Sal polimórfica de 6-cloro-3-amino-2(2-hidroxiprolil) quinolina y usos de la misma |
| US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
| EP3833660A4 (en) | 2018-08-06 | 2022-05-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス， インコーポレイテッド | 多形化合物およびその使用 |
| JP2023526016A (ja) | 2020-05-13 | 2023-06-20 | アルデイラ セラピューティクス， インコーポレイテッド | 医薬製剤およびその使用 |
| CN112079832A (zh) * | 2020-10-30 | 2020-12-15 | 黑龙江中医药大学 | 一种治疗子宫肌瘤的药物及其制备方法 |
| CN114957090B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 稠合异吲哚衍生物的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| GB9123857D0 (en) * | 1991-11-09 | 1992-01-02 | Smithkline Beecham Plc | Novel compounds |
-
1995
- 1995-06-05 US US08/463,528 patent/US5597823A/en not_active Expired - Fee Related
- 1995-12-15 IL IL11640595A patent/IL116405A/en not_active IP Right Cessation
-
1996
- 1996-01-11 EP EP96903340A patent/EP0808318B1/en not_active Expired - Lifetime
- 1996-01-11 ES ES96903340T patent/ES2149451T3/es not_active Expired - Lifetime
- 1996-01-11 DK DK96903340T patent/DK0808318T3/da active
- 1996-01-11 DE DE69609051T patent/DE69609051T2/de not_active Expired - Fee Related
- 1996-01-11 AU AU47457/96A patent/AU705283B2/en not_active Ceased
- 1996-01-11 KR KR1019970705096A patent/KR19980701700A/ko not_active Application Discontinuation
- 1996-01-11 AT AT96903340T patent/ATE194141T1/de not_active IP Right Cessation
- 1996-01-11 WO PCT/US1996/000072 patent/WO1996022992A1/en not_active Application Discontinuation
- 1996-01-11 CA CA002211212A patent/CA2211212A1/en not_active Abandoned
- 1996-01-11 JP JP52286796A patent/JP2001504797A/ja active Pending
- 1996-01-11 MX MX9705674A patent/MX9705674A/es unknown
- 1996-01-11 PT PT96903340T patent/PT808318E/pt unknown
-
2000
- 2000-09-26 GR GR20000402174T patent/GR3034485T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001504797A (ja) | 2001-04-10 |
| MX9705674A (es) | 1997-10-31 |
| DK0808318T3 (da) | 2000-10-16 |
| DE69609051T2 (de) | 2001-03-22 |
| CA2211212A1 (en) | 1996-08-01 |
| US5597823A (en) | 1997-01-28 |
| IL116405A (en) | 2001-09-13 |
| AU705283B2 (en) | 1999-05-20 |
| DE69609051D1 (de) | 2000-08-03 |
| PT808318E (pt) | 2000-12-29 |
| EP0808318B1 (en) | 2000-06-28 |
| ATE194141T1 (de) | 2000-07-15 |
| AU4745796A (en) | 1996-08-14 |
| KR19980701700A (ko) | 1998-06-25 |
| WO1996022992A1 (en) | 1996-08-01 |
| ES2149451T3 (es) | 2000-11-01 |
| EP0808318A1 (en) | 1997-11-26 |
| IL116405A0 (en) | 1996-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR3034485T3 (en) | Tricyclic substituted hexahydrobenz e]isoindole alpha-1 adrenergic antagonists | |
| IL116406A0 (en) | Tricyclic substituted hexahydrobenz (e) isoindole alpha-1 adrenergic antagonists | |
| MX9705313A (es) | Benzazepinas triciclicas antagonistas de la vasopresina. | |
| CA2098176A1 (en) | Angiotensin ii receptor blocking compositions | |
| IE873548L (en) | Peptidylaminodiols | |
| MY132229A (en) | Indole derivatives as 5-ht receptor antagonist | |
| MXPA99000214A (es) | Antagonistas de la vasopresina, a base de benzazepinas triciclicas. | |
| MX9705415A (es) | Antagonsitas de vasopresina triciclicos de benzazepina. | |
| CY2260B1 (en) | Benzopyranopyrrole and benzopyranopyridine alpha-1adrenergic compounds | |
| DE69819166D1 (de) | 8-substituierte-9h-1,3-dioxolo/4,5-h//2,3/benzodiazepin derivate als ampa/kainate-rezeptor-hemmer | |
| PL329190A1 (en) | Antagonists of alpha -adrenergic receptor | |
| DK0823909T3 (da) | Hidtil ukendte heterocykliske forbindelser | |
| MX9708557A (es) | Nuevo uso farmacologico de los antagonistas del receptor aii. | |
| MY118704A (en) | Process for preparation of eprosartan | |
| RO115802B1 (ro) | Derivaţi ai acidului pirazol dihidrobenzofuranil propenoic, intermediar pentru prepararea acestora, compoziţii farmaceutice ale acestora şi metodă de tratament | |
| GR3030506T3 (en) | 1-azaadamantane derivatives as 5-ht agonists or antagonists. | |
| EP0804186A4 (en) | INDOLDITERPEN ALKALOIDS | |
| EP2140862A3 (en) | Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods | |
| EP0976404A3 (en) | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal | |
| BR9713682A (pt) | Compostos alfa - 1 adrenergicos de benzopiranopirrol e benzopiranopiridina | |
| CA2347469A1 (en) | Esters of (+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 100,907 | |
| CA2210631A1 (en) | Tricyclic benzazepine vasopressin antagonists | |
| YU24501A (sh) | Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |