YU24501A - Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
- Google Patents
Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc.filedCriticalAventis Pharmaceuticals Inc.
Priority to YU24501ApriorityCriticalpatent/YU24501A/sh
Publication of YU24501ApublicationCriticalpatent/YU24501A/sh
Ovaj pronalazak je usmeren na estre od (+)-α-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil)etil)-4-piperidinmetanola, formule (I) gde R je C4-C20 alkil, farmaceutske formulacije, postupke dobijanja i postupke korišćenja ovih estara. Ova jedinjenja antagonizuju efekte serotonina na 5HT2A receptor i korisna su u tretiranju različitih stanja takvih, kao, na primer, duševne bolesti takve kao šizofrenija.[The present invention is directed to esters of (+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-lorophenyl)ethyl] -4-piperidinemethanol, of formula (I) wherein R is C4-C20alkyl, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
YU24501A1998-10-141998-10-14Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
YU24501A
(sh)
Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
Substituted indazole derivatives and their application as inhibitors of phosphodiesterase (pde) type iv and of the production of a tumournecrotic factor (tnf)
Esters of (+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 100,907
Estri od(+)-alfa-(2,3-dimetoksifenil)-1-(2-(4-fluorofenil) etil)-4-piperidinmetanola i njihovo korišćenje kao prolekova od 5ht2a receptor antagonista mdl 110,907
Esters of (+)-alpha-(2,3-dimethyloxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pi peridinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 100,907