GR3031939T3 - Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane - Google Patents

Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane

Info

Publication number
GR3031939T3
GR3031939T3 GR990403031T GR990403031T GR3031939T3 GR 3031939 T3 GR3031939 T3 GR 3031939T3 GR 990403031 T GR990403031 T GR 990403031T GR 990403031 T GR990403031 T GR 990403031T GR 3031939 T3 GR3031939 T3 GR 3031939T3
Authority
GR
Greece
Prior art keywords
loweralkyl
independently selected
alkoxy
hydrogen
trifluoromethyl
Prior art date
Application number
GR990403031T
Other languages
English (en)
Inventor
Timothy L Stuk
Francis A J Kerdesky
Linda M Lijewski
Daniel W Norbeck
David Scarpetti
Jien-Heh J Tien
Michael S Allen
Denton C Langridge
Laura Melcher
Daniel S Reno
Hing Leung Sham
Chen Zhao
Anthony R Haight
M Robert Leanna
Howard E Morton
Timothy A Robbins
Thomas J Sowin
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of GR3031939T3 publication Critical patent/GR3031939T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GR990403031T 1993-10-22 1999-11-25 Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane GR3031939T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14179593A 1993-10-22 1993-10-22
US08/281,502 US5491253A (en) 1993-10-22 1994-07-27 Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
PCT/US1994/010852 WO1995011224A1 (en) 1993-10-22 1994-09-26 Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane

Publications (1)

Publication Number Publication Date
GR3031939T3 true GR3031939T3 (en) 2000-03-31

Family

ID=26839452

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990403031T GR3031939T3 (en) 1993-10-22 1999-11-25 Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane

Country Status (12)

Country Link
US (11) US5491253A (el)
EP (2) EP0724563B1 (el)
JP (2) JP3822233B2 (el)
AT (2) ATE238983T1 (el)
CA (1) CA2174000C (el)
DE (2) DE69432611T2 (el)
DK (2) DK0724563T3 (el)
ES (2) ES2198094T3 (el)
GR (1) GR3031939T3 (el)
HK (1) HK1011677A1 (el)
PT (1) PT916646E (el)
WO (1) WO1995011224A1 (el)

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US5750717A (en) * 1994-03-02 1998-05-12 Daicel Chemical Industries, Ltd. 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same
JP3338227B2 (ja) 1995-02-28 2002-10-28 高砂香料工業株式会社 ケトニトリル誘導体及びヘキセノン誘導体の製造方法
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5932766A (en) * 1997-05-30 1999-08-03 Abbott Laboratories Process for the preparation of substituted keto-enamines
MY145265A (en) 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US6307090B1 (en) 1999-01-22 2001-10-23 The United States Of America As Represented By The Department Of Health And Human Services Acylated oligopeptide derivatives having cell signal inhibiting activity
AU770920C (en) * 1999-03-23 2004-10-07 Georgetown University Phenylalanine derivatives
US7226991B1 (en) * 1999-03-23 2007-06-05 United States Of America, Represented By The Secretary, Department Of Health And Human Services Phenylalanine derivatives
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6573409B1 (en) * 1999-07-02 2003-06-03 The Nutrasweet Company Process for the preparation of 3,3-dimethylbutanal
IT1313624B1 (it) 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
US7132392B1 (en) 1999-10-22 2006-11-07 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain
CN100536833C (zh) 2000-01-19 2009-09-09 艾博特公司 改良药物配方
AU2001285133A1 (en) * 2000-08-22 2002-03-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services SH2 domain binding inhibitors
US7425537B2 (en) * 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
US7060165B2 (en) * 2002-02-14 2006-06-13 Pcbu Services, Inc. Processes for purification and production of fluorocarbons
DE60318663T2 (de) * 2002-10-18 2008-06-05 Yokozawa, Tohru, Fujisawa Verfahren zur Herstellung optisch aktiver Aminoalkohole
US20040138104A1 (en) * 2003-01-14 2004-07-15 The Government Of The United States Of America Represented By The Secretary, Peptides
US6933504B2 (en) * 2003-03-12 2005-08-23 General Electric Company CT detector having a segmented optical coupler and method of manufacturing same
US20050119163A1 (en) * 2003-09-18 2005-06-02 The Government Of The United States Of America, As Represented By The Secretary, SH2 domain binding inhibitors
WO2006090264A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs
JP5244597B2 (ja) 2005-09-02 2013-07-24 アムジエン・インコーポレーテツド カルシリティック化合物またはカルシウム模倣性化合物を用いて腸液バランスを調節する方法
US20080160204A1 (en) * 2006-12-28 2008-07-03 Lavoie Adrien R Spontaneous copper seed deposition process for metal interconnects
WO2008149228A1 (en) * 2007-06-08 2008-12-11 Aurobindo Pharma Limited An improved process for the preparation of substantially pure (2s,3s,5s)-5-amino-2-n,n-dibenzylamino-3-hydroxy-1,6-diphenylhexane
JP5204438B2 (ja) * 2007-07-31 2013-06-05 東ソ−・エフテック株式会社 含フッ素アミン化合物の製造方法
CN101967130B (zh) * 2010-07-02 2012-12-26 厦门市亨瑞生化有限公司 利托那韦中间体的合成方法
CN107602454B (zh) * 2017-09-19 2020-12-01 佛山科学技术学院 磺酰胺类化合物及其制备方法和用途
US10529439B2 (en) 2017-10-24 2020-01-07 Spin Memory, Inc. On-the-fly bit failure detection and bit redundancy remapping techniques to correct for fixed bit defects
US10438995B2 (en) 2018-01-08 2019-10-08 Spin Memory, Inc. Devices including magnetic tunnel junctions integrated with selectors

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US2784228A (en) * 1953-08-26 1957-03-05 North Carolina Pharmacentical Alkaline hydrogenation of oximinoketones
GB1383186A (en) * 1972-07-26 1975-02-05 Luso Farmaco Inst Beta-aminoketone derivatives
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5177259A (en) * 1986-04-11 1993-01-05 Warner-Lambert Company Diarylalkanoids having activity as lipoxygenase inhibitors
EP0321497A1 (en) * 1986-09-30 1989-06-28 The Upjohn Company Renin inhibitory peptides having novel c-terminal moieties
NO169837C (no) * 1987-12-21 1992-08-12 Astra Ab Analogifremgangsmaate for fremstilling av nye terapeutisk aktive forbindelser
DE3829594A1 (de) * 1988-09-01 1990-03-15 Bayer Ag Neue renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
JPH06184069A (ja) * 1991-11-19 1994-07-05 Lonza Ag α−ヒドロキシ−β−アミノカルボン酸の製造方法
DE69334250D1 (de) * 1992-12-29 2009-01-29 Abbott Lab Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor

Also Published As

Publication number Publication date
DE69432611D1 (de) 2003-06-05
ES2138667T3 (es) 2000-01-16
PT916646E (pt) 2003-09-30
EP0916646A2 (en) 1999-05-19
US5543549A (en) 1996-08-06
DK0916646T3 (da) 2003-08-25
US5491253A (en) 1996-02-13
ES2198094T3 (es) 2004-01-16
DE69432611T2 (de) 2004-03-18
US5541328A (en) 1996-07-30
EP0916646B1 (en) 2003-05-02
EP0724563A1 (en) 1996-08-07
DE69420421T2 (de) 2000-05-04
US5543552A (en) 1996-08-06
JPH09504024A (ja) 1997-04-22
JP2006206597A (ja) 2006-08-10
CA2174000C (en) 2005-05-24
ATE238983T1 (de) 2003-05-15
HK1011677A1 (en) 1999-07-16
US5616776A (en) 1997-04-01
JP3822233B2 (ja) 2006-09-13
CA2174000A1 (en) 1995-04-27
US5569777A (en) 1996-10-29
JP4172717B2 (ja) 2008-10-29
ATE183993T1 (de) 1999-09-15
EP0724563B1 (en) 1999-09-01
WO1995011224A1 (en) 1995-04-27
EP0916646A3 (en) 1999-08-18
DK0724563T3 (da) 2000-03-20
US5625092A (en) 1997-04-29
US5543551A (en) 1996-08-06
US5508409A (en) 1996-04-16
DE69420421D1 (de) 1999-10-07
US5565604A (en) 1996-10-15
US5654466A (en) 1997-08-05

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