ES2138667T3 - Productos intermediarios para la preparacion de un 2,5-diamino-3-hidroxihexano sustituido. - Google Patents
Productos intermediarios para la preparacion de un 2,5-diamino-3-hidroxihexano sustituido.Info
- Publication number
- ES2138667T3 ES2138667T3 ES94929340T ES94929340T ES2138667T3 ES 2138667 T3 ES2138667 T3 ES 2138667T3 ES 94929340 T ES94929340 T ES 94929340T ES 94929340 T ES94929340 T ES 94929340T ES 2138667 T3 ES2138667 T3 ES 2138667T3
- Authority
- ES
- Spain
- Prior art keywords
- loweralkyl
- independently selected
- alkoxy
- hydrogen
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE DESCRIBEN INTERMEDIARIOS Y PROCESOS QUE SON UTILES EN LA PREPARACION DE UN COMPUESTO SUSTANCIALMENTE PURO DE FORMULA (3), EN DONDE R{SUB,6} Y R{SUB,7} SON CADA UNO HIDROGENO O R{SUB,6} Y R{SUB,7} SON INDEPENDIENTEMENTE SELECCIONADOS DE (I), EN DONDE R{SUB,A} Y R{SUB,B} SON INDEPENDIENTEMENTE SELECCIONADOS DE HIDROGENO, ALQUILO BAJO Y FENILO Y R{SUB,C}, R{SUB,D} Y R{SUB,E} SON INDEPENDIENTEMENTE SELECCIONADOS DE HIDROGENO, ALQUILO BAJO, TRIFLUOROMETILO, ALCOXI, HALOGENO Y FENILO; Y (II) EN DONDE EL ANILLO DE NAFTILO ES NO SUSTITUIDO O SUSTITUIDO CON UNO, DOS O TRES SUSTITUYENTES INDEPENDIENTEMENTE SELECCIONADOS DE ALQUILO BAJO, TRIFLUOROMETILO, ALCOXI Y HALOGENO; O R{SUB,6} ES COMO SE DEFINE MAS ARRIBA Y R{SUB,7} ES R{SUB,7A}OC (O) - EN DONDE R{SUB,7A} ES ALQUILO BAJO O BENCILO; O R{SUB,6} Y R{SUB,7} TOMADOS JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS SON (A) O (B), EN DONDE R{SUB,F}, R{SUB,G}, R{SUB,H} Y R{SUB,I} SON INDEPENDIENTEMENTE SELECCIONADOS DE HIDROGENO, ALQUILO BAJO, ALCOXI, HALOGENO Y TRIFLUOROMETILO Y R{SUB,8} ES HIDROGENO O C(O)R{SUP,"} EN DONDE R{SUP,"} ES ALQUILO BAJO, ALCOXI, BENZILOXI O FENILO EN DONDE EL ANILLO DE FENILO ES NO SUSTITUIDO O SUSTITUIDO CON UNO, DOS O TRES SUSTITUYENTES INDEPENDIENTEMENTE SELECCIONADOS DE ALQUILO BAJO, TRIFLUOROMETILO, ALCOXI Y HALOGENO; O UNA SAL DE ADICION ACIDA DEL MISMO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14179593A | 1993-10-22 | 1993-10-22 | |
US08/281,502 US5491253A (en) | 1993-10-22 | 1994-07-27 | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2138667T3 true ES2138667T3 (es) | 2000-01-16 |
Family
ID=26839452
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94929340T Expired - Lifetime ES2138667T3 (es) | 1993-10-22 | 1994-09-26 | Productos intermediarios para la preparacion de un 2,5-diamino-3-hidroxihexano sustituido. |
ES99101692T Expired - Lifetime ES2198094T3 (es) | 1993-10-22 | 1994-09-26 | Proceso para la preparacion de un 2,5-diamino-3-hidroxihexano sustituido. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99101692T Expired - Lifetime ES2198094T3 (es) | 1993-10-22 | 1994-09-26 | Proceso para la preparacion de un 2,5-diamino-3-hidroxihexano sustituido. |
Country Status (12)
Country | Link |
---|---|
US (11) | US5491253A (es) |
EP (2) | EP0916646B1 (es) |
JP (2) | JP3822233B2 (es) |
AT (2) | ATE238983T1 (es) |
CA (1) | CA2174000C (es) |
DE (2) | DE69432611T2 (es) |
DK (2) | DK0916646T3 (es) |
ES (2) | ES2138667T3 (es) |
GR (1) | GR3031939T3 (es) |
HK (1) | HK1011677A1 (es) |
PT (1) | PT916646E (es) |
WO (1) | WO1995011224A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5750717A (en) * | 1994-03-02 | 1998-05-12 | Daicel Chemical Industries, Ltd. | 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same |
JP3338227B2 (ja) * | 1995-02-28 | 2002-10-28 | 高砂香料工業株式会社 | ケトニトリル誘導体及びヘキセノン誘導体の製造方法 |
US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
US5932766A (en) * | 1997-05-30 | 1999-08-03 | Abbott Laboratories | Process for the preparation of substituted keto-enamines |
CO5090830A1 (es) | 1998-07-20 | 2001-10-30 | Abbott Lab | Poliformo de un agente farmaceutico |
US6307090B1 (en) | 1999-01-22 | 2001-10-23 | The United States Of America As Represented By The Department Of Health And Human Services | Acylated oligopeptide derivatives having cell signal inhibiting activity |
ATE509026T1 (de) * | 1999-03-23 | 2011-05-15 | Us Gov Health & Human Serv | Phenylalanin- derivate |
US7226991B1 (en) * | 1999-03-23 | 2007-06-05 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phenylalanine derivatives |
US6765019B1 (en) * | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
US6573409B1 (en) * | 1999-07-02 | 2003-06-03 | The Nutrasweet Company | Process for the preparation of 3,3-dimethylbutanal |
IT1313624B1 (it) | 1999-09-21 | 2002-09-09 | Archimica Spa Ora Clariant Lif | Procedimento per la sintesi del ritonavir |
US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
DE60034959T2 (de) | 1999-10-22 | 2008-01-17 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren |
SI2269591T1 (en) | 2000-01-19 | 2018-08-31 | Abbvie Inc. | Improved pharmaceutical formulations |
AU2001285133A1 (en) * | 2000-08-22 | 2002-03-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | SH2 domain binding inhibitors |
US7425537B2 (en) * | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
US7060165B2 (en) * | 2002-02-14 | 2006-06-13 | Pcbu Services, Inc. | Processes for purification and production of fluorocarbons |
EP1411045B1 (en) * | 2002-10-18 | 2008-01-16 | Tohru Yokozawa | Process for production of optically active amino alcohols |
US20040138104A1 (en) * | 2003-01-14 | 2004-07-15 | The Government Of The United States Of America Represented By The Secretary, | Peptides |
US6933504B2 (en) * | 2003-03-12 | 2005-08-23 | General Electric Company | CT detector having a segmented optical coupler and method of manufacturing same |
US20050119163A1 (en) * | 2003-09-18 | 2005-06-02 | The Government Of The United States Of America, As Represented By The Secretary, | SH2 domain binding inhibitors |
WO2006090264A1 (en) * | 2005-02-28 | 2006-08-31 | Ranbaxy Laboratories Limited | A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs |
US8486381B2 (en) | 2005-09-02 | 2013-07-16 | Amgen Inc. | Methods of modulating intestinal fluid balance |
US20080160204A1 (en) * | 2006-12-28 | 2008-07-03 | Lavoie Adrien R | Spontaneous copper seed deposition process for metal interconnects |
US8236991B2 (en) * | 2007-06-08 | 2012-08-07 | Aurobindo Pharma Ltd. | Process for the preparation of substantially pure (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane |
JP5204438B2 (ja) * | 2007-07-31 | 2013-06-05 | 東ソ−・エフテック株式会社 | 含フッ素アミン化合物の製造方法 |
CN101967130B (zh) * | 2010-07-02 | 2012-12-26 | 厦门市亨瑞生化有限公司 | 利托那韦中间体的合成方法 |
CN107602454B (zh) * | 2017-09-19 | 2020-12-01 | 佛山科学技术学院 | 磺酰胺类化合物及其制备方法和用途 |
US10529439B2 (en) | 2017-10-24 | 2020-01-07 | Spin Memory, Inc. | On-the-fly bit failure detection and bit redundancy remapping techniques to correct for fixed bit defects |
US10438995B2 (en) | 2018-01-08 | 2019-10-08 | Spin Memory, Inc. | Devices including magnetic tunnel junctions integrated with selectors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US2784228A (en) * | 1953-08-26 | 1957-03-05 | North Carolina Pharmacentical | Alkaline hydrogenation of oximinoketones |
GB1383186A (en) * | 1972-07-26 | 1975-02-05 | Luso Farmaco Inst | Beta-aminoketone derivatives |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5177259A (en) * | 1986-04-11 | 1993-01-05 | Warner-Lambert Company | Diarylalkanoids having activity as lipoxygenase inhibitors |
WO1988002374A2 (en) * | 1986-09-30 | 1988-04-07 | The Upjohn Company | Renin inhibitory peptides having novel c-terminal moieties |
NO169837C (no) * | 1987-12-21 | 1992-08-12 | Astra Ab | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive forbindelser |
DE3829594A1 (de) * | 1988-09-01 | 1990-03-15 | Bayer Ag | Neue renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
JPH06184069A (ja) * | 1991-11-19 | 1994-07-05 | Lonza Ag | α−ヒドロキシ−β−アミノカルボン酸の製造方法 |
PT727419E (pt) * | 1992-12-29 | 2002-08-30 | Abbott Lab | Compostos intermediarios para a preparacao de inibidores da protease retroviral |
IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
-
1994
- 1994-07-27 US US08/281,502 patent/US5491253A/en not_active Expired - Lifetime
- 1994-09-26 WO PCT/US1994/010852 patent/WO1995011224A1/en active IP Right Grant
- 1994-09-26 DK DK99101692T patent/DK0916646T3/da active
- 1994-09-26 DE DE69432611T patent/DE69432611T2/de not_active Expired - Fee Related
- 1994-09-26 ES ES94929340T patent/ES2138667T3/es not_active Expired - Lifetime
- 1994-09-26 EP EP99101692A patent/EP0916646B1/en not_active Expired - Lifetime
- 1994-09-26 AT AT99101692T patent/ATE238983T1/de not_active IP Right Cessation
- 1994-09-26 CA CA002174000A patent/CA2174000C/en not_active Expired - Lifetime
- 1994-09-26 JP JP51182995A patent/JP3822233B2/ja not_active Expired - Lifetime
- 1994-09-26 EP EP94929340A patent/EP0724563B1/en not_active Expired - Lifetime
- 1994-09-26 PT PT99101692T patent/PT916646E/pt unknown
- 1994-09-26 DE DE69420421T patent/DE69420421T2/de not_active Expired - Fee Related
- 1994-09-26 ES ES99101692T patent/ES2198094T3/es not_active Expired - Lifetime
- 1994-09-26 DK DK94929340T patent/DK0724563T3/da active
- 1994-09-26 AT AT94929340T patent/ATE183993T1/de not_active IP Right Cessation
-
1995
- 1995-03-31 US US08/414,876 patent/US5508409A/en not_active Expired - Lifetime
- 1995-03-31 US US08/414,974 patent/US5565604A/en not_active Expired - Lifetime
- 1995-04-03 US US08/415,385 patent/US5541328A/en not_active Expired - Lifetime
- 1995-04-03 US US08/415,403 patent/US5543549A/en not_active Expired - Lifetime
- 1995-04-07 US US08/418,705 patent/US5616776A/en not_active Expired - Lifetime
- 1995-04-07 US US08/418,727 patent/US5569777A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,301 patent/US5543551A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,168 patent/US5625092A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,327 patent/US5543552A/en not_active Expired - Lifetime
-
1996
- 1996-03-29 US US08/625,783 patent/US5654466A/en not_active Expired - Lifetime
-
1998
- 1998-11-30 HK HK98112593A patent/HK1011677A1/xx not_active IP Right Cessation
-
1999
- 1999-11-25 GR GR990403031T patent/GR3031939T3/el unknown
-
2006
- 2006-02-28 JP JP2006052376A patent/JP4172717B2/ja not_active Expired - Lifetime
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