GR3031028T3 - Improved pulsatile once-a-day delivery systems for minocycline - Google Patents
Improved pulsatile once-a-day delivery systems for minocyclineInfo
- Publication number
- GR3031028T3 GR3031028T3 GR990402106T GR990402106T GR3031028T3 GR 3031028 T3 GR3031028 T3 GR 3031028T3 GR 990402106 T GR990402106 T GR 990402106T GR 990402106 T GR990402106 T GR 990402106T GR 3031028 T3 GR3031028 T3 GR 3031028T3
- Authority
- GR
- Greece
- Prior art keywords
- minocycline
- release
- delivery systems
- systems
- medium
- Prior art date
Links
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title abstract 4
- 229960004023 minocycline Drugs 0.000 title abstract 4
- 230000000541 pulsatile effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Treatment Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Laser Surgery Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Position Fixing By Use Of Radio Waves (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/844,109 US5262173A (en) | 1992-03-02 | 1992-03-02 | Pulsatile once-a-day delivery systems for minocycline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3031028T3 true GR3031028T3 (en) | 1999-12-31 |
Family
ID=25291839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR990402106T GR3031028T3 (en) | 1992-03-02 | 1999-08-18 | Improved pulsatile once-a-day delivery systems for minocycline |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US5262173A (enExample) |
| EP (1) | EP0558913B1 (enExample) |
| JP (1) | JPH069407A (enExample) |
| KR (1) | KR100270491B1 (enExample) |
| CN (1) | CN1039194C (enExample) |
| AT (1) | ATE181504T1 (enExample) |
| AU (1) | AU656841B2 (enExample) |
| CA (1) | CA2090561C (enExample) |
| CZ (1) | CZ283684B6 (enExample) |
| DE (1) | DE69325402T2 (enExample) |
| DK (1) | DK0558913T3 (enExample) |
| ES (1) | ES2134221T3 (enExample) |
| FI (1) | FI110163B (enExample) |
| GR (1) | GR3031028T3 (enExample) |
| HU (1) | HU219580B (enExample) |
| IL (1) | IL104865A (enExample) |
| LV (1) | LV12399B (enExample) |
| MX (1) | MX9300998A (enExample) |
| NO (1) | NO307170B1 (enExample) |
| NZ (1) | NZ245951A (enExample) |
| PL (1) | PL171609B1 (enExample) |
| SG (1) | SG47785A1 (enExample) |
| TW (1) | TW299235B (enExample) |
| ZA (1) | ZA931444B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4031881C2 (de) * | 1990-10-08 | 1994-02-24 | Sanol Arznei Schwarz Gmbh | Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung |
| WO1996010996A1 (en) * | 1993-07-21 | 1996-04-18 | The University Of Kentucky Research Foundation | A multicompartment hard capsule with control release properties |
| US5538737A (en) * | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
| GB9518465D0 (en) * | 1995-09-09 | 1995-11-08 | Smithkline Beecham Seiyaku Kk | Pharmaceuticals |
| ZA974359B (en) * | 1996-05-23 | 1998-05-12 | Zeneca Ltd | Microencapsulated compositions. |
| US5932437A (en) * | 1998-04-13 | 1999-08-03 | Genesis Laboratories, Inc. | Control of lyme disease spirochete |
| IL141762A0 (en) * | 1998-10-01 | 2002-03-10 | Novartis Ag | New oral formulations |
| JP2000119181A (ja) * | 1998-10-06 | 2000-04-25 | Kureha Chem Ind Co Ltd | エスクレチン及びその誘導体の放出制御経口製剤 |
| IL142896A0 (en) * | 1998-11-02 | 2002-04-21 | Elan Corp Plc | Multiparticulate modified release composition |
| US20090149479A1 (en) * | 1998-11-02 | 2009-06-11 | Elan Pharma International Limited | Dosing regimen |
| US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US20050137181A1 (en) * | 1999-03-17 | 2005-06-23 | Bonner Ernest L. | Method for treatment of reactive arthritis or bursitis |
| US6765000B2 (en) * | 1999-03-17 | 2004-07-20 | Bonner Jr Ernest L | Treatment for reactive arthritis or bursitis |
| US7691831B2 (en) * | 1999-03-17 | 2010-04-06 | Ernest L. Bonner, Jr. | Pharmaceutical combination and method for treatment of reactive arthritis or bursitis |
| US7884090B2 (en) * | 1999-03-17 | 2011-02-08 | Ernest L. Bonner, Jr. | Compositions and methods for the treatment of arthritis |
| WO2000059481A1 (en) * | 1999-04-06 | 2000-10-12 | Pharmaquest Ltd. | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF d-threo-METHYLPHENIDATE AND A SECOND CNS STIMULANT |
| US20030170181A1 (en) * | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
| EP2295043A1 (en) | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| TR200201112T2 (tr) * | 1999-10-29 | 2002-12-23 | Fmc Corporation | Yenebilir kaplama kompozisyonu |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| US6500462B1 (en) | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| AU2002227383B2 (en) | 2000-10-30 | 2004-07-08 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| US6699315B2 (en) | 2000-11-28 | 2004-03-02 | Fmc Corporation | Edible PGA coating composition |
| CA2447008A1 (en) * | 2001-04-05 | 2002-10-24 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| CA2449731A1 (en) * | 2001-06-07 | 2002-12-19 | Tanabe Seiyaku Co., Ltd. | Functional grain-containing preparations quickly disintegrated in the oral cavity |
| US6958161B2 (en) | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
| ES2530791T3 (es) | 2002-12-20 | 2015-03-05 | Hoffmann La Roche | Formulación de ibandronato de altas dosis |
| CA2521885C (en) * | 2003-04-07 | 2013-06-25 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| GB2414668B (en) * | 2004-06-03 | 2009-07-29 | Dexcel Ltd | Tetracycline modified release delivery system |
| US8461187B2 (en) | 2004-06-16 | 2013-06-11 | Takeda Pharmaceuticals U.S.A., Inc. | Multiple PPI dosage form |
| US20060121112A1 (en) * | 2004-12-08 | 2006-06-08 | Elan Corporation, Plc | Topiramate pharmaceutical composition |
| BRPI0608917A2 (pt) * | 2005-04-12 | 2017-07-11 | Elan Pharma Int Ltd | Composição de liberação controlada de antibiótico, e, método para o tratamento de infecção bacteriana |
| US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| US20080242642A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US9192615B2 (en) | 2008-08-06 | 2015-11-24 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| US7544373B2 (en) * | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7541347B2 (en) * | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
| US20080318910A1 (en) * | 2005-10-04 | 2008-12-25 | Mistral Pharma, Inc. | Controlled-Release Oral Dosage Form |
| US20070166273A1 (en) * | 2006-01-19 | 2007-07-19 | Krivulka Joseph J | Skin treatment educational kit |
| PT103661B (pt) * | 2007-02-23 | 2010-09-07 | Hovione Farmaciencia S A | Processo de preparação de minociclina base cristalina |
| US20080226734A1 (en) * | 2007-03-16 | 2008-09-18 | Elan Corporation Plc | Combination of a narcotic and non-narcotic analgesic |
| US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
| RU2010119041A (ru) | 2007-10-12 | 2011-11-20 | Такеда Фармасьютикалз Норт Америка, Инк. (Us) | Способы лечения нарушений желудочно-кишечного тракта, независимого от потребления пищи |
| CA2868990C (en) | 2011-04-22 | 2018-08-14 | Napo Pharmaceuticals, Inc. | Pharmacologically optimized multimodal drug delivery system for nordihydroguiaretic acid (ndga) |
| EP2704698B1 (de) | 2011-05-05 | 2019-10-02 | Hennig Arzneimittel GmbH&Co. Kg | Arzneiform zur gezielten freigabe von wirkstoffen |
| DE102011075354A1 (de) * | 2011-05-05 | 2012-11-08 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur gezielten Freigabe von Wirkstoffen |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| US11103517B2 (en) | 2015-04-07 | 2021-08-31 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions for minocycline |
| CN108414466A (zh) * | 2018-03-09 | 2018-08-17 | 浙江美华鼎昌医药科技有限公司 | 一种盐酸米诺环素缓释片体外溶出测定方法 |
| MX2020011599A (es) * | 2018-04-30 | 2021-01-15 | Melinta Therapeutics Inc | Métodos de tratamiento de infecciones bacterianas con minociclina. |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL270408A (enExample) * | 1960-10-20 | |||
| US3865935A (en) * | 1972-08-10 | 1975-02-11 | Abbott Lab | Tableting of erythromycin base |
| US4250166A (en) * | 1977-05-27 | 1981-02-10 | Shionogi & Co., Ltd. | Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin |
| GB1561204A (en) * | 1977-06-01 | 1980-02-13 | Ici Ltd | Sustained release pharmaceutical composition |
| US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| FR2447192A1 (fr) * | 1979-01-25 | 1980-08-22 | Adria Lab Inc | Forme galenique a liberation prolongee d'indoprofene |
| US4353887A (en) * | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
| DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| JPS61210025A (ja) * | 1985-03-14 | 1986-09-18 | Teisan Seiyaku Kk | 安定化された抗生物質複合顆粒製剤 |
| GB8521494D0 (en) * | 1985-08-29 | 1985-10-02 | Zyma Sa | Controlled release tablet |
| US4808413A (en) * | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
| US4837030A (en) * | 1987-10-06 | 1989-06-06 | American Cyanamid Company | Novel controlled release formulations of tetracycline compounds |
| EP0327295A3 (en) * | 1988-02-01 | 1989-09-06 | F.H. FAULDING & CO. LTD. | Tetracycline dosage form |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| IL95423A (en) * | 1989-09-21 | 1994-11-11 | American Cyanamid Co | Pulsatile once-a-day delivery systems for minocycline |
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| US5286497A (en) * | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
-
1992
- 1992-03-02 US US07/844,109 patent/US5262173A/en not_active Expired - Lifetime
-
1993
- 1993-01-25 EP EP93101096A patent/EP0558913B1/en not_active Expired - Lifetime
- 1993-01-25 ES ES93101096T patent/ES2134221T3/es not_active Expired - Lifetime
- 1993-01-25 SG SG1996004364A patent/SG47785A1/en unknown
- 1993-01-25 DE DE69325402T patent/DE69325402T2/de not_active Expired - Lifetime
- 1993-01-25 DK DK93101096T patent/DK0558913T3/da active
- 1993-01-25 AT AT93101096T patent/ATE181504T1/de not_active IP Right Cessation
- 1993-02-22 NZ NZ245951A patent/NZ245951A/en not_active IP Right Cessation
- 1993-02-24 MX MX9300998A patent/MX9300998A/es unknown
- 1993-02-25 IL IL10486593A patent/IL104865A/xx not_active IP Right Cessation
- 1993-02-25 CN CN93101947A patent/CN1039194C/zh not_active Expired - Lifetime
- 1993-02-26 CA CA002090561A patent/CA2090561C/en not_active Expired - Lifetime
- 1993-02-26 AU AU33842/93A patent/AU656841B2/en not_active Expired
- 1993-02-27 KR KR1019930002984A patent/KR100270491B1/ko not_active Expired - Lifetime
- 1993-03-01 PL PL93297903A patent/PL171609B1/pl unknown
- 1993-03-01 FI FI930906A patent/FI110163B/fi not_active IP Right Cessation
- 1993-03-01 CZ CZ93300A patent/CZ283684B6/cs not_active IP Right Cessation
- 1993-03-01 NO NO930743A patent/NO307170B1/no not_active IP Right Cessation
- 1993-03-01 HU HU9300570A patent/HU219580B/hu not_active IP Right Cessation
- 1993-03-01 JP JP5062500A patent/JPH069407A/ja active Pending
- 1993-03-01 ZA ZA931444A patent/ZA931444B/xx unknown
- 1993-04-02 TW TW082102503A patent/TW299235B/zh active
- 1993-06-23 US US08/081,632 patent/US5348748A/en not_active Expired - Lifetime
-
1999
- 1999-08-18 GR GR990402106T patent/GR3031028T3/el unknown
- 1999-09-16 LV LVP-99-133A patent/LV12399B/en unknown
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