GR3026436T3 - Stabilization of somatotropins by modification of cysteine residues - Google Patents
Stabilization of somatotropins by modification of cysteine residuesInfo
- Publication number
- GR3026436T3 GR3026436T3 GR970403459T GR970403459T GR3026436T3 GR 3026436 T3 GR3026436 T3 GR 3026436T3 GR 970403459 T GR970403459 T GR 970403459T GR 970403459 T GR970403459 T GR 970403459T GR 3026436 T3 GR3026436 T3 GR 3026436T3
- Authority
- GR
- Greece
- Prior art keywords
- polypeptides
- proteins
- cysteine residues
- somatotropins
- stabilization
- Prior art date
Links
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 title abstract 2
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 235000018102 proteins Nutrition 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51904790A | 1990-05-04 | 1990-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3026436T3 true GR3026436T3 (en) | 1998-06-30 |
Family
ID=24066559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970403459T GR3026436T3 (en) | 1990-05-04 | 1998-03-24 | Stabilization of somatotropins by modification of cysteine residues |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0458064B1 (el) |
| JP (1) | JPH069696A (el) |
| KR (1) | KR100213455B1 (el) |
| AT (1) | ATE163431T1 (el) |
| AU (1) | AU639324B2 (el) |
| CA (1) | CA2041742A1 (el) |
| DE (1) | DE69128944T2 (el) |
| DK (1) | DK0458064T3 (el) |
| ES (1) | ES2113354T3 (el) |
| FI (1) | FI912144A (el) |
| GR (1) | GR3026436T3 (el) |
| IE (1) | IE911511A1 (el) |
| IL (1) | IL97932A (el) |
| NO (1) | NO911752L (el) |
| NZ (1) | NZ237959A (el) |
| PT (1) | PT97539B (el) |
| ZA (1) | ZA913359B (el) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
| WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
| US5336488A (en) * | 1991-08-07 | 1994-08-09 | American Cyanamid Company | Method of treating or preventing mastitis in animals with involuting mammary glands by administering recombinant cytokines |
| AU666914B2 (en) * | 1991-12-10 | 1996-02-29 | Tanox Biosystems, Inc. | Cytokines with an unpaired cysteine residue and conjugates thereof |
| JPH08506095A (ja) * | 1992-11-25 | 1996-07-02 | アムジェン ボールダー インコーポレイテッド | 改変インシュリン様成長因子 |
| EP0622394A1 (en) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use |
| WO1999003887A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
| US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| AU2008202371B2 (en) * | 1999-01-14 | 2012-08-02 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| DE60129432T2 (de) | 2000-05-16 | 2008-04-17 | Bolder Biotechnology, Inc., Louisville | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
| WO2002055532A2 (en) * | 2001-01-11 | 2002-07-18 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
| MXPA04004809A (es) * | 2001-11-20 | 2004-08-11 | Pharmacia Corp | Conjugados de hormona de crecimiento humana modificada quimicamente. |
| BR0317742A (pt) | 2002-12-26 | 2005-11-22 | Mountain View Pharmaceuticals | Conjugados poliméricos de interferon-beta com potência biológica aumentada |
| US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| JP2007508250A (ja) * | 2003-10-10 | 2007-04-05 | ノボ ノルディスク アクティーゼルスカブ | 持続性放出製剤における長期作用性分子 |
| WO2007041614A2 (en) | 2005-10-03 | 2007-04-12 | Bolder Biotechnology, Inc. | Long acting vegf inhibitors and methods of use |
| EP2102355B1 (en) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
| CN103002918B (zh) * | 2010-01-22 | 2016-05-04 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| ES2841123T3 (es) | 2013-04-05 | 2021-07-07 | Formulacion Del Compuesto De La Hormona De Crecimiento | Formulación del compuesto de la hormona de crecimiento |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2514950B2 (ja) * | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質，その製造法および中間体 |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
-
1991
- 1991-04-18 DK DK91106224.8T patent/DK0458064T3/da active
- 1991-04-18 AT AT91106224T patent/ATE163431T1/de not_active IP Right Cessation
- 1991-04-18 DE DE69128944T patent/DE69128944T2/de not_active Expired - Fee Related
- 1991-04-18 ES ES91106224T patent/ES2113354T3/es not_active Expired - Lifetime
- 1991-04-18 EP EP91106224A patent/EP0458064B1/en not_active Expired - Lifetime
- 1991-04-24 IL IL97932A patent/IL97932A/en not_active IP Right Cessation
- 1991-04-26 NZ NZ237959A patent/NZ237959A/en unknown
- 1991-04-29 AU AU76075/91A patent/AU639324B2/en not_active Ceased
- 1991-05-02 CA CA002041742A patent/CA2041742A1/en not_active Abandoned
- 1991-05-02 JP JP3128190A patent/JPH069696A/ja active Pending
- 1991-05-02 PT PT97539A patent/PT97539B/pt not_active IP Right Cessation
- 1991-05-03 KR KR1019910007216A patent/KR100213455B1/ko not_active IP Right Cessation
- 1991-05-03 IE IE151191A patent/IE911511A1/en not_active Application Discontinuation
- 1991-05-03 NO NO91911752A patent/NO911752L/no unknown
- 1991-05-03 ZA ZA913359A patent/ZA913359B/xx unknown
- 1991-05-03 FI FI912144A patent/FI912144A/fi not_active Application Discontinuation
-
1998
- 1998-03-24 GR GR970403459T patent/GR3026436T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR910020032A (ko) | 1991-12-19 |
| FI912144A (fi) | 1991-11-05 |
| IL97932A (en) | 1998-02-22 |
| EP0458064A2 (en) | 1991-11-27 |
| CA2041742A1 (en) | 1991-11-05 |
| NZ237959A (en) | 1994-05-26 |
| DE69128944D1 (de) | 1998-04-02 |
| DK0458064T3 (da) | 1998-04-27 |
| ES2113354T3 (es) | 1998-05-01 |
| ATE163431T1 (de) | 1998-03-15 |
| KR100213455B1 (ko) | 1999-08-02 |
| AU7607591A (en) | 1991-11-07 |
| PT97539A (pt) | 1992-02-28 |
| EP0458064B1 (en) | 1998-02-25 |
| IE911511A1 (en) | 1991-11-06 |
| JPH069696A (ja) | 1994-01-18 |
| NO911752D0 (no) | 1991-05-03 |
| NO911752L (no) | 1991-11-05 |
| DE69128944T2 (de) | 1998-06-25 |
| ZA913359B (en) | 1992-03-25 |
| AU639324B2 (en) | 1993-07-22 |
| IL97932A0 (en) | 1992-06-21 |
| PT97539B (pt) | 1998-08-31 |
| EP0458064A3 (en) | 1992-06-17 |
| FI912144A0 (fi) | 1991-05-03 |
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