GR3007287T3 - - Google Patents

Info

Publication number
GR3007287T3
GR3007287T3 GR930400510T GR930400510T GR3007287T3 GR 3007287 T3 GR3007287 T3 GR 3007287T3 GR 930400510 T GR930400510 T GR 930400510T GR 930400510 T GR930400510 T GR 930400510T GR 3007287 T3 GR3007287 T3 GR 3007287T3
Authority
GR
Greece
Prior art keywords
melphalan
hydrochloride
substantially pure
mephalan
citrate
Prior art date
Application number
GR930400510T
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GR3007287T3 publication Critical patent/GR3007287T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
GR930400510T 1987-11-19 1993-03-09 GR3007287T3 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878727157A GB8727157D0 (en) 1987-11-19 1987-11-19 Pharmaceutical formulations

Publications (1)

Publication Number Publication Date
GR3007287T3 true GR3007287T3 (el) 1993-07-30

Family

ID=10627252

Family Applications (1)

Application Number Title Priority Date Filing Date
GR930400510T GR3007287T3 (el) 1987-11-19 1993-03-09

Country Status (22)

Country Link
US (1) US4997651A (el)
EP (1) EP0317281B1 (el)
JP (1) JP2693191B2 (el)
KR (1) KR970002607B1 (el)
AT (1) ATE83922T1 (el)
AU (1) AU619781B2 (el)
CA (1) CA1341114C (el)
DE (1) DE3877151T2 (el)
DK (1) DK172794B1 (el)
ES (1) ES2052745T3 (el)
FI (2) FI90204C (el)
GB (1) GB8727157D0 (el)
GR (1) GR3007287T3 (el)
HK (1) HK108994A (el)
HU (3) HU206671B (el)
IE (1) IE63996B1 (el)
IL (1) IL88419A (el)
LV (1) LV10179B (el)
NZ (2) NZ227004A (el)
PT (1) PT89028B (el)
SG (1) SG73894G (el)
ZA (1) ZA888674B (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407672A (en) * 1993-04-08 1995-04-18 Cornell Research Foundation, Inc. Enhancing the anti-tumor effect of melphalan with L-amino acid oxidase
US5695751A (en) * 1993-04-08 1997-12-09 Cornell Research Foundation, Inc. Enhancing delivery of large neutral amino acid drugs
US6020004A (en) * 1997-04-17 2000-02-01 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs
US5980904A (en) * 1998-11-18 1999-11-09 Amway Corporation Skin whitening composition containing bearberry extract and a reducing agent
GB2386066A (en) * 2002-02-28 2003-09-10 Norbrook Lab Ltd Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
JP2005535626A (ja) * 2002-06-24 2005-11-24 リサーチ　ディベロップメント　ファンデーション クルクミンによるヒト多発性骨髄腫の治療
EP1694335A4 (en) 2003-08-26 2008-12-31 Res Dev Foundation OSTEOCLASTOGENESIS HEMMER AND ITS USES
US8501818B2 (en) 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
LT2273876T (lt) 2008-03-27 2019-05-27 Helsinn Healthcare Sa Stabilizuotos alkilinimo medžiagų kompozicijos ir jų panaudojimo būdai
AR066943A1 (es) * 2008-06-10 2009-09-23 Eriochem Sa Una composicion farmaceutica de melfalano
EP2434886B1 (en) * 2009-05-29 2019-10-16 CyDex Pharmaceuticals, Inc. Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
AR077384A1 (es) * 2010-07-05 2011-08-24 Eriochem Sa Una formulacion farmaceutica inyectable de melfalano.
US8921596B2 (en) * 2010-11-04 2014-12-30 Emcure Pharmaceuticals, Ltd. Process for the preparation of melphalan hydrochloride
DK3228319T3 (da) 2011-04-28 2020-09-07 Oncopeptides Ab Lyofiliseret præparat af cytotoksiske dipeptider
JP6284945B2 (ja) * 2012-10-26 2018-02-28 オンコペプティデス エービーＯｎｃｏｐｅｐｔｉｄｅｓ ＡＢ メルファランフルフェナミドの凍結乾燥製剤
US9963422B2 (en) 2013-03-11 2018-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of melphalan and the hydrochloride salt
ITMI20130896A1 (it) 2013-05-31 2014-12-01 Farmabios Spa Processo di purificazione di melphalan
BR112017018869A2 (pt) * 2015-03-06 2018-04-17 Leadiant Biosciences S.A roneparstat e roneparstat para o uso, kit de partes e kit de partes para o uso, composição farmacêutica, método para tratar um mamífero e método para inibição, tratamento, e/ou prevenção de mieloma múltiplo, mieloma de células plasmáticas, mieloma recorrente, refratário ou recidivante em um sujeito
US10537520B2 (en) * 2015-06-30 2020-01-21 Leiutis Pharmaceuticals Pvt. Ltd. Stable liquid formulations of melphalan
KR20200136997A (ko) * 2018-03-29 2020-12-08 프로젝트 파마슈틱스 게엠베하 액체 약학적 제형
US10682326B1 (en) 2019-06-03 2020-06-16 Shilpa Medicare Limited Stable melphalan liquid injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB750155A (en) * 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines
US3032585A (en) * 1954-12-03 1962-05-01 Nat Res Dev Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine
DE1292660B (de) * 1963-04-24 1969-04-17 Ural Polytechnitscheskij I Im Verfahren zur Herstellung von p-(Bis-ª‰-chloraethyl-amino)-phenylalanin-hydrochlorid
US4029778A (en) * 1969-01-23 1977-06-14 Aktiebolaget Leo Cortical steroid nitrogen mustard compositions and treatment therewith
RO57195A2 (el) * 1970-11-30 1974-09-01
FR2285855A1 (fr) * 1974-09-25 1976-04-23 Kohjin Co Composition therapeutique lyophilisee a base de sel de cyclocytidine et son procede de preparation
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4696814A (en) * 1985-08-21 1987-09-29 Warner-Lambert Company Parenteral phenytoin compositions
JPS62192357A (ja) * 1986-02-19 1987-08-22 Kureha Chem Ind Co Ltd Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法

Also Published As

Publication number Publication date
IE883447L (en) 1989-05-19
EP0317281A3 (en) 1989-08-09
JP2693191B2 (ja) 1997-12-24
FI885358A (fi) 1989-05-20
FI924668A (fi) 1992-10-15
IL88419A0 (en) 1989-06-30
FI924668A0 (fi) 1992-10-15
LV10179B (en) 1995-06-20
PT89028A (pt) 1988-12-01
NZ227004A (en) 1992-11-25
FI102275B1 (fi) 1998-11-13
DK646688D0 (da) 1988-11-18
HU9100335D0 (en) 1991-08-28
FI885358A0 (fi) 1988-11-18
AU619781B2 (en) 1992-02-06
HUT48198A (en) 1989-05-29
EP0317281A2 (en) 1989-05-24
EP0317281B1 (en) 1992-12-30
DK646688A (da) 1989-05-20
HK108994A (en) 1994-10-14
AU2574888A (en) 1989-05-25
IE63996B1 (en) 1995-06-28
DK172794B1 (da) 1999-07-19
JPH01153628A (ja) 1989-06-15
DE3877151D1 (de) 1993-02-11
ES2052745T3 (es) 1994-07-16
HU910336D0 (en) 1991-08-28
LV10179A (lv) 1994-10-20
FI90204B (fi) 1993-09-30
PT89028B (pt) 1993-02-26
FI90204C (fi) 1994-01-10
FI102275B (fi) 1998-11-13
KR890007729A (ko) 1989-07-05
HU206671B (en) 1992-12-28
US4997651A (en) 1991-03-05
HU203197B (en) 1991-06-28
CA1341114C (en) 2000-10-10
NZ239867A (en) 1992-11-25
DE3877151T2 (de) 1993-07-15
HU207286B (en) 1993-03-29
ATE83922T1 (de) 1993-01-15
IL88419A (en) 1993-03-15
GB8727157D0 (en) 1987-12-23
ZA888674B (en) 1990-07-25
SG73894G (en) 1994-11-25
KR970002607B1 (ko) 1997-03-06

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