GR1000266B - Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων. - Google Patents

Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων.

Info

Publication number
GR1000266B
GR1000266B GR880100688A GR880100688A GR1000266B GR 1000266 B GR1000266 B GR 1000266B GR 880100688 A GR880100688 A GR 880100688A GR 880100688 A GR880100688 A GR 880100688A GR 1000266 B GR1000266 B GR 1000266B
Authority
GR
Greece
Prior art keywords
polyester
preparation
composition based
pharmaceutical substances
controlled emission
Prior art date
Application number
GR880100688A
Other languages
English (en)
Inventor
Frederic Heimgartner
Piero Orsolini
Urs Schleuniger
Peter Speiser
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of GR1000266B publication Critical patent/GR1000266B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Μια μέθοδος παρασκευής μιας φαρμακευτικής σύνθεσης, συγκεκριμένα μια φαρμακευτική σύνθεση προορισμένη για διατηρούμενη και ελεγχόμενη έκλυση μιας αποτελεσματικής δόσης μιας φαρμακευτικής ουσίας. Περιλαμβάνει, ως φορέα για τη φαρμακευτική ουσία, ένα βιοαποδομούμενο πολυμερές ή συμπολυμερές ή ένα μίγμα βιοαποδομούμενων πολυμερών και/ή συμπολυμερών, προερχομένων από ένα δικαρβοξυλικό οξύ επιλεγμένο από οξέα του κύκλου Krebs και από μια αλειφατική διόλη περιέχοντας 4 άτομα άνθρακα ή από κυκλοεξανο-1,4- διμεθανόλη. ω
GR880100688A 1987-10-14 1988-10-13 Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων. GR1000266B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH4022/87A CH672887A5 (el) 1987-10-14 1987-10-14

Publications (1)

Publication Number Publication Date
GR1000266B true GR1000266B (el) 1992-05-12

Family

ID=4268357

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100688A GR1000266B (el) 1987-10-14 1988-10-13 Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων.

Country Status (14)

Country Link
JP (1) JP2716747B2 (el)
BE (1) BE1001687A5 (el)
CA (1) CA1332808C (el)
CH (1) CH672887A5 (el)
DE (1) DE3835099A1 (el)
DK (1) DK571488A (el)
ES (1) ES2009347A6 (el)
FR (1) FR2622105B1 (el)
GB (1) GB2211091B (el)
GR (1) GR1000266B (el)
IE (1) IE60475B1 (el)
IT (1) IT1227394B (el)
NL (1) NL8802490A (el)
PT (1) PT88757B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
CH681425A5 (el) * 1990-11-14 1993-03-31 Debio Rech Pharma Sa
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
ZA936692B (en) * 1992-09-12 1994-04-29 Dott Ltd Comp Physiologically active peptide composition
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
FR2777895A1 (fr) * 1998-04-28 1999-10-29 Debio Rech Pharma Sa Polymere sequence non-reticule,procede pour sa preparation, et ses utilisations
WO2004108792A2 (en) * 2003-04-10 2004-12-16 Vinod Chintamani Malshe Novel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978203A (en) * 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
WO1978000011A1 (en) * 1977-06-07 1978-12-21 Garching Instrumente Form of implant medicament and preparation process
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)
EP0144534A2 (en) * 1983-09-20 1985-06-19 Allied Corporation prosthetic devices

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130639A (en) * 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4481353A (en) * 1983-10-07 1984-11-06 The Children's Medical Center Corporation Bioresorbable polyesters and polyester composites

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978203A (en) * 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
WO1978000011A1 (en) * 1977-06-07 1978-12-21 Garching Instrumente Form of implant medicament and preparation process
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)
EP0144534A2 (en) * 1983-09-20 1985-06-19 Allied Corporation prosthetic devices

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
GB2211091A (en) 1989-06-28
NL8802490A (nl) 1989-05-01
DE3835099A1 (de) 1989-04-27
JPH01157920A (ja) 1989-06-21
DK571488A (da) 1989-04-15
GB2211091B (en) 1991-02-13
CH672887A5 (el) 1990-01-15
FR2622105B1 (fr) 1993-05-14
DK571488D0 (da) 1988-10-13
ES2009347A6 (es) 1989-09-16
BE1001687A5 (fr) 1990-02-06
PT88757B (pt) 1993-01-29
GB8823735D0 (en) 1988-11-16
IE883110L (en) 1989-04-14
FR2622105A1 (fr) 1989-04-28
JP2716747B2 (ja) 1998-02-18
IT1227394B (it) 1991-04-08
CA1332808C (en) 1994-11-01
IE60475B1 (en) 1994-07-13
IT8805224A0 (it) 1988-10-11

Similar Documents

Publication Publication Date Title
Wood Biodegradable drug delivery systems
US5434242A (en) Catalyst-free resorbable homopolymers and copolymers
Uhrich et al. Polymeric systems for controlled drug release
DK561588A (da) Implanterbart biologisk nedbrydeligt system til frigivelse af biologisk virksomme stoffer
US5028667B1 (el)
KR920700017A (ko) 투입된 원위치에서 형성되는 생분해성 이식조직
HU911222D0 (en) Process for producing macromolecular polymers being biologically decomposable and for producing pharmaceutical preparatives containing said compounds
DE69121675D1 (de) Mikrosphäre enthaltende pharmazeutische Zusammensetzung mit kontrollierter Freigabe und Verfahren zur Herstellung
DE69534163D1 (de) Polymerteilchen zur arzneimittelabgabe
NZ204643A (en) Controlled release device containing polymer and acid anhydride
SE8803321D0 (sv) Fordrojd och styrd frigoring av vattenolosliga polypeptider
JP2001517603A (ja) 薬物送達における使用のための注射可能な生分解性ブロックコポリマーゲル
RU93004902A (ru) Композиция пролонгированного контролируемого высвобождения пептидного лекарственного вещества и способ ее получения
ATE69725T1 (de) Pharmazeutische zubereitungen von acrivastine.
GR1000266B (el) Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων.
JPS6442433A (en) Fine particle containing biodegradable polymer for controlling release of antimalarial effective component, medicinal composition and manufacture
KR880008806A (ko) 경구용 서방성 약제학적 제제
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
DE69943225D1 (de) Flüssige Polymerlosung zur Kontrollierten freisetzung von bioaktiven substanzen
Pulkkinen Modified poly (ε-caprolactone) and poly (lactic acid) polymers for controlled and targeted drug delivery
Burrows The Influence of Block Copolymers on Some Properties of Biodegradable Polymer Blends
JP2005537309A (ja) 生物活性化合物が長期に放出される生分解性組成物およびその調製
CA2029062A1 (en) Biodegradable polymer compositions

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees