GEP20207058B - Imidazopyrazinones as pde1 inhibitors - Google Patents

Imidazopyrazinones as pde1 inhibitors

Info

Publication number
GEP20207058B
GEP20207058B GEAP201614615A GEAP2016014615A GEP20207058B GE P20207058 B GEP20207058 B GE P20207058B GE AP201614615 A GEAP201614615 A GE AP201614615A GE AP2016014615 A GEAP2016014615 A GE AP2016014615A GE P20207058 B GEP20207058 B GE P20207058B
Authority
GE
Georgia
Prior art keywords
imidazopyrazinones
pde1 inhibitors
psychical
mers
tau
Prior art date
Application number
GEAP201614615A
Other languages
English (en)
Inventor
Lundbeck A/ H
Original Assignee
Lundbeck A/ H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck A/ H filed Critical Lundbeck A/ H
Publication of GEP20207058B publication Critical patent/GEP20207058B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
GEAP201614615A 2015-04-30 2016-04-29 Imidazopyrazinones as pde1 inhibitors GEP20207058B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201500261 2015-04-30
DKPA201500666 2015-10-29
DKPA201600202 2016-04-04

Publications (1)

Publication Number Publication Date
GEP20207058B true GEP20207058B (en) 2020-01-27

Family

ID=55910242

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201614615A GEP20207058B (en) 2015-04-30 2016-04-29 Imidazopyrazinones as pde1 inhibitors

Country Status (42)

Country Link
US (4) US20160318939A1 (cg-RX-API-DMAC7.html)
EP (1) EP3288944B1 (cg-RX-API-DMAC7.html)
JP (1) JP6663930B2 (cg-RX-API-DMAC7.html)
KR (1) KR102605759B1 (cg-RX-API-DMAC7.html)
CN (1) CN107531714B (cg-RX-API-DMAC7.html)
AU (1) AU2016256573B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017023182B1 (cg-RX-API-DMAC7.html)
CA (1) CA2983563A1 (cg-RX-API-DMAC7.html)
CL (1) CL2017002719A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017010399A2 (cg-RX-API-DMAC7.html)
CY (1) CY1121806T1 (cg-RX-API-DMAC7.html)
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DO (1) DOP2017000254A (cg-RX-API-DMAC7.html)
EA (1) EA031946B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP17072228A (cg-RX-API-DMAC7.html)
ES (1) ES2735422T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20207058B (cg-RX-API-DMAC7.html)
GT (1) GT201700223A (cg-RX-API-DMAC7.html)
HK (1) HK1252098B (cg-RX-API-DMAC7.html)
HR (1) HRP20191180T1 (cg-RX-API-DMAC7.html)
HU (1) HUE044244T2 (cg-RX-API-DMAC7.html)
IL (1) IL255316B (cg-RX-API-DMAC7.html)
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MA (1) MA41977B1 (cg-RX-API-DMAC7.html)
ME (1) ME03414B (cg-RX-API-DMAC7.html)
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MY (1) MY182382A (cg-RX-API-DMAC7.html)
PE (1) PE20180121A1 (cg-RX-API-DMAC7.html)
PH (1) PH12017501990B1 (cg-RX-API-DMAC7.html)
PL (1) PL3288944T3 (cg-RX-API-DMAC7.html)
PT (1) PT3288944T (cg-RX-API-DMAC7.html)
RS (1) RS59051B1 (cg-RX-API-DMAC7.html)
RU (1) RU2712219C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201708822PA (cg-RX-API-DMAC7.html)
SI (1) SI3288944T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900393T1 (cg-RX-API-DMAC7.html)
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UA (1) UA123050C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016174188A1 (cg-RX-API-DMAC7.html)
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JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商H 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
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JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
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JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
AR105668A1 (es) 2015-08-12 2017-10-25 H Lundbeck As 2-amino-3-fluoro-3-(fluorometil)-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商H 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
EP3529250B1 (en) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as pde1 inhibitors
US10912773B2 (en) 2016-10-28 2021-02-09 H. Lundbeck A/S Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
MA46611B1 (fr) 2016-10-28 2020-08-31 H Lundbeck As Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs

Also Published As

Publication number Publication date
HK1252098B (en) 2020-02-07
US20170291903A1 (en) 2017-10-12
SG11201708822PA (en) 2017-11-29
US20160318939A1 (en) 2016-11-03
GT201700223A (es) 2018-12-19
DOP2017000254A (es) 2018-01-15
ES2735422T3 (es) 2019-12-18
US20190062335A1 (en) 2019-02-28
HRP20191180T1 (hr) 2019-10-04
EP3288944A1 (en) 2018-03-07
ZA201706847B (en) 2019-01-30
EP3288944B1 (en) 2019-06-12
PL3288944T3 (pl) 2019-11-29
MX2017013785A (es) 2018-03-27
TN2017000428A1 (en) 2019-04-12
JP2018514552A (ja) 2018-06-07
JO3627B1 (ar) 2020-08-27
RS59051B1 (sr) 2019-08-30
PH12017501990B1 (en) 2021-01-13
MX375737B (es) 2025-03-06
PE20180121A1 (es) 2018-01-18
RU2712219C2 (ru) 2020-01-27
AU2016256573A1 (en) 2017-12-14
KR20170140216A (ko) 2017-12-20
CN107531714B (zh) 2019-07-19
RU2017137514A3 (cg-RX-API-DMAC7.html) 2019-07-17
HK1252098A1 (en) 2019-05-17
IL255316B (en) 2021-10-31
KR102605759B1 (ko) 2023-11-23
TWI695838B (zh) 2020-06-11
ECSP17072228A (es) 2018-02-28
TW201700477A (zh) 2017-01-01
EA201792157A1 (ru) 2018-03-30
SI3288944T1 (sl) 2019-08-30
MY182382A (en) 2021-01-22
BR112017023182A2 (cg-RX-API-DMAC7.html) 2018-10-02
DK3288944T3 (da) 2019-07-22
CL2017002719A1 (es) 2018-04-20
WO2016174188A1 (en) 2016-11-03
MA41977A (fr) 2018-07-23
ME03414B (me) 2020-01-20
CO2017010399A2 (es) 2018-01-05
LT3288944T (lt) 2019-07-25
AU2016256573B2 (en) 2019-11-21
EA031946B1 (ru) 2019-03-29
US11472810B2 (en) 2022-10-18
CN107531714A (zh) 2018-01-02
CA2983563A1 (en) 2016-11-03
HUE044244T2 (hu) 2019-10-28
SMT201900393T1 (it) 2019-09-09
MA41977B1 (fr) 2019-08-30
PT3288944T (pt) 2019-07-19
IL255316A0 (en) 2017-12-31
RU2017137514A (ru) 2019-05-31
JP6663930B2 (ja) 2020-03-13
CY1121806T1 (el) 2020-07-31
BR112017023182B1 (pt) 2023-10-31
PH12017501990A1 (en) 2018-03-26
US10858362B2 (en) 2020-12-08
UA123050C2 (uk) 2021-02-10
US10011606B2 (en) 2018-07-03
US20210238182A1 (en) 2021-08-05

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