GEP20043239B - C10 Carbonate Substituted Taxanes as Antitumor Agents - Google Patents
C10 Carbonate Substituted Taxanes as Antitumor AgentsInfo
- Publication number
- GEP20043239B GEP20043239B GEAP20016129A GEAP2001006129A GEP20043239B GE P20043239 B GEP20043239 B GE P20043239B GE AP20016129 A GEAP20016129 A GE AP20016129A GE AP2001006129 A GEAP2001006129 A GE AP2001006129A GE P20043239 B GEP20043239 B GE P20043239B
- Authority
- GE
- Georgia
- Prior art keywords
- antitumor agents
- carbonate substituted
- substituted taxanes
- taxanes
- carbonate
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000005587 carbonate group Chemical group 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17968400P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP20043239B true GEP20043239B (en) | 2004-05-25 |
Family
ID=22657547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP20016129A GEP20043239B (en) | 2000-02-02 | 2001-02-02 | C10 Carbonate Substituted Taxanes as Antitumor Agents |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6660866B2 (https=) |
| EP (1) | EP1165550A1 (https=) |
| JP (1) | JP2003522171A (https=) |
| KR (1) | KR20010111582A (https=) |
| CN (1) | CN1186340C (https=) |
| AU (1) | AU782028B2 (https=) |
| BG (1) | BG65298B1 (https=) |
| BR (1) | BR0104779A (https=) |
| CA (1) | CA2368151A1 (https=) |
| CZ (1) | CZ20013405A3 (https=) |
| GE (1) | GEP20043239B (https=) |
| HU (1) | HUP0200759A3 (https=) |
| IL (1) | IL145636A0 (https=) |
| MX (1) | MXPA01009902A (https=) |
| NO (1) | NO20014753L (https=) |
| NZ (1) | NZ514074A (https=) |
| PL (1) | PL350028A1 (https=) |
| RO (1) | RO121269B1 (https=) |
| RU (1) | RU2264400C2 (https=) |
| SK (1) | SK13632001A3 (https=) |
| TR (1) | TR200102855T1 (https=) |
| UA (1) | UA75038C2 (https=) |
| WO (1) | WO2001057031A1 (https=) |
| ZA (2) | ZA200108058B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01009900A (es) * | 2000-02-02 | 2003-08-20 | Univ Florida State Res Found | Formulaciones de taxano que tienen solubilidad mejorada. |
| IL145637A0 (en) * | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents |
| RO121269B1 (ro) * | 2000-02-02 | 2007-02-28 | Florida State University Research Foundation, Inc. | Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali |
| US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2354478A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| US20060189679A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
| RU2352340C1 (ru) * | 2007-06-27 | 2009-04-20 | Федеральное Государственное Учреждение Ростовский научно-исследовательский онкологический институт Росмедтехнологий | Способ химиотерапии при раке мочевого пузыря |
| RU2370261C2 (ru) * | 2007-08-03 | 2009-10-20 | Закрытое Акционерное Общество "Биокад" | Стабильная эмульсия для парентерального введения плохо растворимых в воде соединений, обладающих противоопухолевой активностью, и способ ее получения |
| JP2011517455A (ja) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| SG46582A1 (en) | 1991-09-23 | 1998-02-20 | Univ Florida State | 10-Desacetoxytaxol derivatives |
| PT552041E (pt) | 1992-01-15 | 2000-12-29 | Squibb & Sons Inc | Processo enzimaticos para a resolucao de misturas enantiomericas de compostos uteis como intermediarios para a preparacao de taxanos |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5698712A (en) | 1992-03-06 | 1997-12-16 | Indena S.P.A. | Baccatine III derivatives |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| FR2691460B1 (fr) | 1992-05-21 | 1994-07-22 | Rhone Poulenc Rorer Sa | Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent. |
| US5254580A (en) | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| CA2109861C (en) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| DE4241664C2 (de) | 1992-12-04 | 1995-04-06 | Borus Spezialverfahren | Elektronisches Lebensdetektionssystem |
| MX9307777A (es) | 1992-12-15 | 1994-07-29 | Upjohn Co | 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. |
| CA2111527C (en) | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| FR2702212B1 (fr) | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| IT1261667B (it) | 1993-05-20 | 1996-05-29 | Tassano ad attivita' antitumorale. | |
| ES2145829T3 (es) | 1993-06-11 | 2000-07-16 | Upjohn Co | Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen. |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| IL127597A (en) * | 1994-01-28 | 2003-07-31 | Upjohn Co | Iso-taxol analogs |
| FR2721024B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US6100411A (en) | 1994-10-28 | 2000-08-08 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
| EP0788493A1 (en) * | 1994-10-28 | 1997-08-13 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| CA2162759A1 (en) | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
| FR2732342B1 (fr) | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2732968B1 (fr) | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5801191A (en) * | 1995-06-01 | 1998-09-01 | Biophysica Foundation | Taxoids |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| FR2742751B1 (fr) * | 1995-12-22 | 1998-01-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2745814B1 (fr) * | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| WO1997042181A1 (en) | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| JPH1045583A (ja) | 1996-05-14 | 1998-02-17 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| CA2259977C (en) | 1996-07-15 | 2005-06-28 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JP2003026673A (ja) * | 1999-03-05 | 2003-01-29 | Asahi Kasei Corp | 骨形成促進剤 |
| RO121269B1 (ro) * | 2000-02-02 | 2007-02-28 | Florida State University Research Foundation, Inc. | Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
-
2001
- 2001-02-02 RO ROA200101082A patent/RO121269B1/ro unknown
- 2001-02-02 KR KR1020017012590A patent/KR20010111582A/ko not_active Ceased
- 2001-02-02 BR BR0104779-5A patent/BR0104779A/pt not_active IP Right Cessation
- 2001-02-02 CN CNB018001483A patent/CN1186340C/zh not_active Expired - Fee Related
- 2001-02-02 CZ CZ20013405A patent/CZ20013405A3/cs unknown
- 2001-02-02 US US09/776,274 patent/US6660866B2/en not_active Expired - Fee Related
- 2001-02-02 PL PL01350028A patent/PL350028A1/xx not_active Application Discontinuation
- 2001-02-02 MX MXPA01009902A patent/MXPA01009902A/es active IP Right Grant
- 2001-02-02 TR TR2001/02855T patent/TR200102855T1/xx unknown
- 2001-02-02 EP EP01905420A patent/EP1165550A1/en not_active Withdrawn
- 2001-02-02 GE GEAP20016129A patent/GEP20043239B/en unknown
- 2001-02-02 AU AU33301/01A patent/AU782028B2/en not_active Ceased
- 2001-02-02 UA UA2001106731A patent/UA75038C2/uk unknown
- 2001-02-02 HU HU0200759A patent/HUP0200759A3/hu unknown
- 2001-02-02 WO PCT/US2001/003588 patent/WO2001057031A1/en not_active Ceased
- 2001-02-02 SK SK1363-2001A patent/SK13632001A3/sk unknown
- 2001-02-02 JP JP2001557863A patent/JP2003522171A/ja not_active Withdrawn
- 2001-02-02 IL IL14563601A patent/IL145636A0/xx unknown
- 2001-02-02 CA CA002368151A patent/CA2368151A1/en not_active Abandoned
- 2001-02-02 RU RU2001129533/04A patent/RU2264400C2/ru not_active IP Right Cessation
- 2001-02-02 NZ NZ514074A patent/NZ514074A/xx unknown
- 2001-10-01 BG BG105964A patent/BG65298B1/bg unknown
- 2001-10-01 ZA ZA200108058A patent/ZA200108058B/en unknown
- 2001-10-01 NO NO20014753A patent/NO20014753L/no not_active Application Discontinuation
- 2001-10-01 ZA ZA200108054A patent/ZA200108054B/xx unknown
-
2003
- 2003-11-24 US US10/720,615 patent/US7056946B2/en not_active Expired - Fee Related
-
2006
- 2006-01-12 US US11/330,770 patent/US7256213B2/en not_active Expired - Fee Related
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