GB997399A - Phenol ethers that contain basic groups - Google Patents
Phenol ethers that contain basic groupsInfo
- Publication number
- GB997399A GB997399A GB13456/64A GB1345664A GB997399A GB 997399 A GB997399 A GB 997399A GB 13456/64 A GB13456/64 A GB 13456/64A GB 1345664 A GB1345664 A GB 1345664A GB 997399 A GB997399 A GB 997399A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- basic groups
- contain basic
- aralkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008379 phenol ethers Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000012320 chlorinating reagent Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 150000002641 lithium Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEC29547A DE1199764B (de) | 1963-04-02 | 1963-04-02 | Verfahren zur Herstellung von basisch substituierten Phenolaethern |
DEC0029548 | 1963-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB997399A true GB997399A (en) | 1965-07-07 |
Family
ID=25969656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13456/64A Expired GB997399A (en) | 1963-04-02 | 1964-04-01 | Phenol ethers that contain basic groups |
Country Status (10)
Country | Link |
---|---|
AT (1) | AT244325B (xx) |
BE (1) | BE646062A (xx) |
BR (1) | BR6457725D0 (xx) |
CH (1) | CH439273A (xx) |
DE (1) | DE1199764B (xx) |
FI (1) | FI42320C (xx) |
FR (2) | FR1543914A (xx) |
GB (1) | GB997399A (xx) |
NL (1) | NL139662B (xx) |
SE (1) | SE300615B (xx) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0753506A1 (de) * | 1995-07-11 | 1997-01-15 | Grünenthal GmbH | 6-dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe |
EP0780369A1 (de) * | 1995-12-20 | 1997-06-25 | Grünenthal GmbH | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-olverbindungen als pharmazeutische Wirkstoffe |
US5877351A (en) * | 1997-12-24 | 1999-03-02 | Wyckoff Chemical Company, Inc. | Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts |
ES2141688A1 (es) * | 1998-11-06 | 2000-05-16 | Vita Invest Sa | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
US6254887B1 (en) | 1993-05-10 | 2001-07-03 | Euro-Celtique S.A. | Controlled release tramadol |
WO2001049650A1 (es) * | 1999-12-30 | 2001-07-12 | Vita-Invest, S. A. | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo |
WO2001064202A2 (en) * | 2000-03-01 | 2001-09-07 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
US6469213B1 (en) | 1997-07-15 | 2002-10-22 | Russinsky Limited | Tramadol, salts thereof and process for their preparation |
WO2003048113A1 (en) * | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
US7470816B2 (en) | 2005-11-14 | 2008-12-30 | Ipac Laboratories Limited | Tramadol recovery process |
WO2012102875A3 (en) * | 2011-01-27 | 2012-10-18 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3623193A1 (de) * | 1986-07-10 | 1988-01-14 | Gruenenthal Gmbh | Neue verbindungen, diese enthaltende arzneimittel und verfahren zu deren herstellung |
-
1963
- 1963-04-02 DE DEC29547A patent/DE1199764B/de active Pending
-
1964
- 1964-03-02 CH CH261264A patent/CH439273A/de unknown
- 1964-03-04 AT AT187464A patent/AT244325B/de active
- 1964-03-17 FI FI57464A patent/FI42320C/fi active
- 1964-03-19 BR BR15772564A patent/BR6457725D0/pt unknown
- 1964-03-25 NL NL646403199A patent/NL139662B/xx not_active IP Right Cessation
- 1964-03-26 SE SE383364A patent/SE300615B/xx unknown
- 1964-04-01 GB GB13456/64A patent/GB997399A/en not_active Expired
- 1964-04-02 BE BE646062D patent/BE646062A/xx unknown
- 1964-04-02 FR FR969555A patent/FR1543914A/fr not_active Expired
- 1964-04-02 FR FR969467A patent/FR3618M/fr active Active
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6254887B1 (en) | 1993-05-10 | 2001-07-03 | Euro-Celtique S.A. | Controlled release tramadol |
US6326027B1 (en) | 1993-05-10 | 2001-12-04 | Euro-Celtique S.A. | Controlled release formulation |
CN1122018C (zh) * | 1995-07-11 | 2003-09-24 | 格吕伦塔尔有限公司 | 作为药用活性成分的6-二甲氨基甲基-1-苯基环己烷化合物 |
EP0753506A1 (de) * | 1995-07-11 | 1997-01-15 | Grünenthal GmbH | 6-dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe |
AU703890B2 (en) * | 1995-07-11 | 1999-04-01 | Grunenthal Gmbh | 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients |
KR100470013B1 (ko) * | 1995-07-11 | 2005-06-08 | 그뤼넨탈 게엠베하 | 약제학적활성성분으로서의6-디메틸아미노메틸-1-페닐-사이클로헥산화합물 |
AU705970B2 (en) * | 1995-12-20 | 1999-06-03 | Grunenthal Gmbh | 1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients |
CN1071309C (zh) * | 1995-12-20 | 2001-09-19 | 格吕伦塔尔有限公司 | 用作药物活性成分的1-苯基-2-二甲氨基甲基-环己-1-醇化合物 |
EP0780369A1 (de) * | 1995-12-20 | 1997-06-25 | Grünenthal GmbH | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-olverbindungen als pharmazeutische Wirkstoffe |
US5801201A (en) * | 1995-12-20 | 1998-09-01 | Gruenenthal Gmbh | 1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients |
US6469213B1 (en) | 1997-07-15 | 2002-10-22 | Russinsky Limited | Tramadol, salts thereof and process for their preparation |
US5877351A (en) * | 1997-12-24 | 1999-03-02 | Wyckoff Chemical Company, Inc. | Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts |
WO2000027799A1 (es) * | 1998-11-06 | 2000-05-18 | Vita-Invest, S.A. | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos |
EP1219623A1 (en) * | 1998-11-06 | 2002-07-03 | Vita-Invest, S.A. | New esters derived from substituted phenyl-cyclohexyl compounds |
EP1219594A1 (en) * | 1998-11-06 | 2002-07-03 | Vita-Invest, S.A. | New esters derived from substituted phenyl-cyclohexyl compounds |
AP1222A (en) * | 1998-11-06 | 2003-11-06 | Laboratorios Vita S A | New esters from substituted phenyl-cyclohexyl compounds. |
ES2141688A1 (es) * | 1998-11-06 | 2000-05-16 | Vita Invest Sa | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
ES2160534A1 (es) * | 1999-12-30 | 2001-11-01 | Vita Invest Sa | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. |
WO2001049650A1 (es) * | 1999-12-30 | 2001-07-12 | Vita-Invest, S. A. | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo |
US6894076B2 (en) | 1999-12-30 | 2005-05-17 | Vita-Invest, S.A. | Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl |
AP1234A (en) * | 1999-12-30 | 2003-12-28 | Laboratorios Vita S A | New esters derived from (RR,SS)-3-(2-Dimethylaminomethyl-1-hydroxycyclohexyl) phenyl 2-hydroxybenzoate. |
WO2001064202A3 (en) * | 2000-03-01 | 2002-08-01 | Euro Celtique Sa | Tramadol for the treatment of functional gastrointestinal disorders |
JP2003525241A (ja) * | 2000-03-01 | 2003-08-26 | ユーロセルティック ソシエテ アノニム | 機能性胃腸疾患治療用トラマドール |
WO2001064202A2 (en) * | 2000-03-01 | 2001-09-07 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
US8716347B2 (en) | 2000-03-01 | 2014-05-06 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
US6784319B2 (en) | 2001-10-03 | 2004-08-31 | Euro-Celtique, S.A. | Synthesis of (±)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
US6780891B2 (en) | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
WO2003048113A1 (en) * | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
US7470816B2 (en) | 2005-11-14 | 2008-12-30 | Ipac Laboratories Limited | Tramadol recovery process |
WO2012102875A3 (en) * | 2011-01-27 | 2012-10-18 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
US8802728B2 (en) | 2011-01-27 | 2014-08-12 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
EA024101B1 (ru) * | 2011-01-27 | 2016-08-31 | Эли Лилли Энд Компани | Соединения, обладающие анальгезирующими свойствами, содержащие их составы и их применение в терапии |
Also Published As
Publication number | Publication date |
---|---|
NL139662B (nl) | 1973-09-17 |
FI42320C (fi) | 1970-07-10 |
SE300615B (xx) | 1968-05-06 |
FI42320B (xx) | 1970-03-31 |
DE1199764B (de) | 1965-09-02 |
FR3618M (fr) | 1965-10-18 |
BE646062A (xx) | 1964-10-02 |
FR1543914A (fr) | 1968-10-31 |
AT244325B (de) | 1965-12-27 |
CH439273A (de) | 1967-07-15 |
NL6403199A (xx) | 1964-10-05 |
BR6457725D0 (pt) | 1973-08-28 |
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