GB1060005A - New esters of secondary amino-alcohols - Google Patents

New esters of secondary amino-alcohols

Info

Publication number
GB1060005A
GB1060005A GB3920863A GB3920863A GB1060005A GB 1060005 A GB1060005 A GB 1060005A GB 3920863 A GB3920863 A GB 3920863A GB 3920863 A GB3920863 A GB 3920863A GB 1060005 A GB1060005 A GB 1060005A
Authority
GB
United Kingdom
Prior art keywords
prepared
formula
alkyl
tetrahydropyrans
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3920863A
Inventor
Henri Morren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL125832D priority Critical patent/NL125832C/xx
Application filed by UCB SA filed Critical UCB SA
Priority to GB3920863A priority patent/GB1060005A/en
Priority to NL6411319A priority patent/NL6411319A/xx
Priority to BE653810A priority patent/BE653810A/xx
Priority to SE1181764A priority patent/SE303510B/xx
Priority to IL2216964A priority patent/IL22169A/en
Priority to FR1605113D priority patent/FR1605113A/en
Priority to AT841364A priority patent/AT244964B/en
Priority to ES0304602A priority patent/ES304602A1/en
Priority to CH1281464A priority patent/CH422005A/en
Priority to DK488764A priority patent/DK112590B/en
Priority to FI208664A priority patent/FI42963B/fi
Priority to DE19641518403 priority patent/DE1518403B1/en
Priority to FR318A priority patent/FR4960M/fr
Publication of GB1060005A publication Critical patent/GB1060005A/en
Priority to US634389A priority patent/US3422102A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the Formula I wherein X represents a hydrogen or halogen atom or an alkyl or alkoxy radical, y represents a hydrogen atom or an alkyl radical, Z and Z1, the same or different, represent hydrogen atoms or C1- 4 alkyl radicals or together with the nitrogen atom form a heterocyclic radical which may contain other hetero-atoms, and n represents 1, 2, 3 or 4, and acid addition salts thereof, are prepared by reacting an alcohol of the Formula II with an acid chloride of the Formula III. <FORM:1060005/C2/1> <FORM:1060005/C2/2> <FORM:1060005/C2/3> Carboxylic acid chlorides of the Formula III may be prepared by chlorination of the corresponding carboxylic acids which latter may be prepared by hydrolysis of the corresponding 4-cyano-4-(X-phenyl)-tetrahydropyrans. 4 - Cyano - 4 - (X - phenyl) tetrahydropyrans may be prepared by reacting the corresponding phenylacetonitriles with bis - (2 - chloroethyl) ether in the presence of sodamide.
GB3920863A 1963-10-04 1963-10-04 New esters of secondary amino-alcohols Expired GB1060005A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
NL125832D NL125832C (en) 1963-10-04
GB3920863A GB1060005A (en) 1963-10-04 1963-10-04 New esters of secondary amino-alcohols
NL6411319A NL6411319A (en) 1963-10-04 1964-09-29
BE653810A BE653810A (en) 1963-10-04 1964-10-01
SE1181764A SE303510B (en) 1963-10-04 1964-10-01
IL2216964A IL22169A (en) 1963-10-04 1964-10-01 Esters of secondary amino-alcohols
AT841364A AT244964B (en) 1963-10-04 1964-10-02 Process for the preparation of new esters of secondary amino alcohols
FR1605113D FR1605113A (en) 1963-10-04 1964-10-02 (A) Cpds. of general formulae (I) and (II):- where X = H, halogen, alkyl, alkoxy, carbalkoxy, NH2, alkylcarbamyl Y H, alkyl Z and Z' = same
ES0304602A ES304602A1 (en) 1963-10-04 1964-10-02 New esters of secondary amino-alcohols
CH1281464A CH422005A (en) 1963-10-04 1964-10-02 Process for the preparation of new esters of secondary aminoalcohols
DK488764A DK112590B (en) 1963-10-04 1964-10-03 Process for the preparation of esters of secondary amino alcohols or acid addition salts thereof.
FI208664A FI42963B (en) 1963-10-04 1964-10-03
DE19641518403 DE1518403B1 (en) 1963-10-04 1964-10-03 Basic esters of derivatives of tetrahydropyran-4-carboxylic acid and their pharmacologically non-toxic acid addition salts
FR318A FR4960M (en) 1963-10-04 1964-12-30
US634389A US3422102A (en) 1963-10-04 1967-04-27 Omega tertiary amino-1-methyl alkyl- 4 - phenyl - 4 - tetrahydropyran - 4-carboxylates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3920863A GB1060005A (en) 1963-10-04 1963-10-04 New esters of secondary amino-alcohols

Publications (1)

Publication Number Publication Date
GB1060005A true GB1060005A (en) 1967-02-22

Family

ID=10408291

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3920863A Expired GB1060005A (en) 1963-10-04 1963-10-04 New esters of secondary amino-alcohols

Country Status (12)

Country Link
AT (1) AT244964B (en)
BE (1) BE653810A (en)
CH (1) CH422005A (en)
DE (1) DE1518403B1 (en)
DK (1) DK112590B (en)
ES (1) ES304602A1 (en)
FI (1) FI42963B (en)
FR (2) FR1605113A (en)
GB (1) GB1060005A (en)
IL (1) IL22169A (en)
NL (2) NL6411319A (en)
SE (1) SE303510B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0462830A2 (en) * 1990-06-21 1991-12-27 Zeneca Limited Cyclic ether derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0462830A2 (en) * 1990-06-21 1991-12-27 Zeneca Limited Cyclic ether derivatives
EP0462830A3 (en) * 1990-06-21 1992-02-05 Imperial Chemical Industries Plc Cyclic ether derivatives

Also Published As

Publication number Publication date
NL6411319A (en) 1965-04-05
AT244964B (en) 1966-02-10
ES304602A1 (en) 1965-02-01
DE1518403B1 (en) 1970-07-16
BE653810A (en) 1965-04-01
FR1605113A (en) 1973-03-16
DK112590B (en) 1968-12-30
CH422005A (en) 1966-10-15
NL125832C (en)
IL22169A (en) 1968-01-25
SE303510B (en) 1968-09-02
FI42963B (en) 1970-09-02
FR4960M (en) 1967-04-03

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