GB837086A - New 3-amino-thiophene-2-carboxylic acids and the esters thereof and a process of preparing said acids and esters - Google Patents
New 3-amino-thiophene-2-carboxylic acids and the esters thereof and a process of preparing said acids and estersInfo
- Publication number
- GB837086A GB837086A GB27828/58A GB2782858A GB837086A GB 837086 A GB837086 A GB 837086A GB 27828/58 A GB27828/58 A GB 27828/58A GB 2782858 A GB2782858 A GB 2782858A GB 837086 A GB837086 A GB 837086A
- Authority
- GB
- United Kingdom
- Prior art keywords
- esters
- acids
- alkyl
- thiophene
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0837086/IV (b)/1> wherein R1 and R2 each represent a hydrogen atom, an alkyl or an aryl radical and R3 represents a hydrogen atom or a C1-4 alkyl group. ("Aryl" being defined as an unsubstituted phenyl or an alkyl-, halo- or alkoxy substituted phenyl group) and the preparation thereof by reacting an a :b -dihalogenonitrile: <FORM:0837086/IV (b)/2> wherein X represents a chlorine or bromine atom, with a thioglycollic acid ester in the presence of a condensation agent, and, if desired, hydrolysing the ester to form the free acid. a - b - Dihalogenonitriles are prepared from the corresponding a :b -unsaturated nitriles by addition of halogen. They can also be prepared from a :b -unsaturated nitriles substituted in the a -position.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE837086X | 1957-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB837086A true GB837086A (en) | 1960-06-09 |
Family
ID=6761336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27828/58A Expired GB837086A (en) | 1957-08-29 | 1958-08-29 | New 3-amino-thiophene-2-carboxylic acids and the esters thereof and a process of preparing said acids and esters |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB837086A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299968A (en) | 1973-12-03 | 1981-11-10 | Hoffmann-La Roche Inc. | Novel thiophene compounds |
| US4317915A (en) | 1976-08-23 | 1982-03-02 | Hoffmann-La Roche Inc. | Novel thiophene derivatives |
| US4360681A (en) | 1973-12-03 | 1982-11-23 | Hoffmann-La Roche Inc. | Novel thiophene compounds |
| US4428963A (en) | 1976-08-23 | 1984-01-31 | Hoffmann-La Roche Inc. | Novel thiophene derivatives |
| EP0198206A1 (en) * | 1985-03-22 | 1986-10-22 | Bayer Ag | Azo dyes |
| KR101464280B1 (en) * | 2012-08-23 | 2014-11-24 | 한국과학기술연구원 | Novel compounds as chloride channel blocking agent |
-
1958
- 1958-08-29 GB GB27828/58A patent/GB837086A/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299968A (en) | 1973-12-03 | 1981-11-10 | Hoffmann-La Roche Inc. | Novel thiophene compounds |
| US4360681A (en) | 1973-12-03 | 1982-11-23 | Hoffmann-La Roche Inc. | Novel thiophene compounds |
| US4317915A (en) | 1976-08-23 | 1982-03-02 | Hoffmann-La Roche Inc. | Novel thiophene derivatives |
| US4428963A (en) | 1976-08-23 | 1984-01-31 | Hoffmann-La Roche Inc. | Novel thiophene derivatives |
| EP0198206A1 (en) * | 1985-03-22 | 1986-10-22 | Bayer Ag | Azo dyes |
| US4711954A (en) * | 1985-03-22 | 1987-12-08 | Bayer Aktiengesellschaft | 3-thienylazo dyes with a gamma-acid coupler |
| KR101464280B1 (en) * | 2012-08-23 | 2014-11-24 | 한국과학기술연구원 | Novel compounds as chloride channel blocking agent |
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