GB9708611D0 - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
GB9708611D0
GB9708611D0 GBGB9708611.0A GB9708611A GB9708611D0 GB 9708611 D0 GB9708611 D0 GB 9708611D0 GB 9708611 A GB9708611 A GB 9708611A GB 9708611 D0 GB9708611 D0 GB 9708611D0
Authority
GB
United Kingdom
Prior art keywords
group
alkyl
halogens
cycloalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9708611.0A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Cardiff Consultants Ltd
Cardiff University
Original Assignee
University College Cardiff Consultants Ltd
Cardiff University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Ltd, Cardiff University filed Critical University College Cardiff Consultants Ltd
Priority to GBGB9708611.0A priority Critical patent/GB9708611D0/en
Publication of GB9708611D0 publication Critical patent/GB9708611D0/en
Priority to AT98919313T priority patent/ATE221543T1/de
Priority to JP54673298A priority patent/JP4514242B2/ja
Priority to US09/403,853 priority patent/US6573247B1/en
Priority to EP98919313A priority patent/EP0980377B1/en
Priority to PT98919313T priority patent/PT980377E/pt
Priority to NZ500881A priority patent/NZ500881A/en
Priority to ES98919313T priority patent/ES2181208T3/es
Priority to DE69806919T priority patent/DE69806919T2/de
Priority to AU72193/98A priority patent/AU737902B2/en
Priority to PCT/GB1998/001222 priority patent/WO1998049177A1/en
Priority to DK98919313T priority patent/DK0980377T3/da
Priority to CA002288147A priority patent/CA2288147C/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB9708611.0A 1997-04-28 1997-04-28 Chemical compounds Pending GB9708611D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GBGB9708611.0A GB9708611D0 (en) 1997-04-28 1997-04-28 Chemical compounds
CA002288147A CA2288147C (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
NZ500881A NZ500881A (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
JP54673298A JP4514242B2 (ja) 1997-04-28 1998-04-27 抗ウイルスピリミジンヌクレオシド類似体
US09/403,853 US6573247B1 (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
EP98919313A EP0980377B1 (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
PT98919313T PT980377E (pt) 1997-04-28 1998-04-27 Analogos de nucleosido de pirimidina anti-viral
AT98919313T ATE221543T1 (de) 1997-04-28 1998-04-27 Antivirale pyrimidin-nukleosid-analogen
ES98919313T ES2181208T3 (es) 1997-04-28 1998-04-27 Analogos de nucleosidos de pirimidina antivirales.
DE69806919T DE69806919T2 (de) 1997-04-28 1998-04-27 Antivirale pyrimidin-nukleosid-analogen
AU72193/98A AU737902B2 (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
PCT/GB1998/001222 WO1998049177A1 (en) 1997-04-28 1998-04-27 Anti-viral pyrimidine nucleoside analogues
DK98919313T DK0980377T3 (da) 1997-04-28 1998-04-27 Antivirale pyrimidinnukleosidanaloger

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708611.0A GB9708611D0 (en) 1997-04-28 1997-04-28 Chemical compounds

Publications (1)

Publication Number Publication Date
GB9708611D0 true GB9708611D0 (en) 1997-06-18

Family

ID=10811493

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9708611.0A Pending GB9708611D0 (en) 1997-04-28 1997-04-28 Chemical compounds

Country Status (13)

Country Link
US (1) US6573247B1 (enExample)
EP (1) EP0980377B1 (enExample)
JP (1) JP4514242B2 (enExample)
AT (1) ATE221543T1 (enExample)
AU (1) AU737902B2 (enExample)
CA (1) CA2288147C (enExample)
DE (1) DE69806919T2 (enExample)
DK (1) DK0980377T3 (enExample)
ES (1) ES2181208T3 (enExample)
GB (1) GB9708611D0 (enExample)
NZ (1) NZ500881A (enExample)
PT (1) PT980377E (enExample)
WO (1) WO1998049177A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) * 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues
DE69840216D1 (de) 1997-08-08 2008-12-24 Celmed Oncology Usa Inc Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
ES2172303T3 (es) 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
IL147749A0 (en) 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
GB0011203D0 (en) * 2000-05-09 2000-06-28 Univ Cardiff Chemical compounds
US7144995B2 (en) 2002-03-08 2006-12-05 Glen Research Corporation Fluorescent nitrogenous base and nucleosides incorporating same
PT1576138T (pt) 2002-11-15 2017-05-03 Idenix Pharmaceuticals Llc 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
NZ599290A (en) 2009-10-16 2014-10-31 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
EA201270568A1 (ru) 2009-10-16 2012-11-30 Риб-Экс Фармасьютикалз, Инк. Антимикробные композиции и способы их получения и применения
NZ599291A (en) 2009-10-16 2014-06-27 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
EP2691409B1 (en) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
MY173518A (en) 2011-04-15 2020-01-30 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
GB201111779D0 (en) 2011-07-08 2011-08-24 Univ Cardiff Chemical compounds
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
EP2768838A1 (en) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
BR112014029115A8 (pt) 2012-05-22 2018-04-03 Idenix Pharmaceuticals Inc Composto, composição farmacêutica, e, uso de um composto ou composição
EP2852604B1 (en) 2012-05-22 2017-04-12 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphoramidate prodrugs for hcv infection
EP2852605B1 (en) 2012-05-22 2018-01-31 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphate prodrugs for hcv infection
ES2597757T3 (es) 2012-05-25 2017-01-20 Janssen Sciences Ireland Uc Nucleósidos de uracilespirooxetano
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
BR112015007698A2 (pt) 2012-10-08 2017-08-22 Idenix Pharmaceuticals Inc Centre National De La Recherche Scientifique E Univ Montpellier 2 Science Composto, composição farmacêutica, e, uso de um composto
EP2909222B1 (en) 2012-10-22 2021-05-26 Idenix Pharmaceuticals LLC 2',4'-bridged nucleosides for hcv infection
WO2014099941A1 (en) 2012-12-19 2014-06-26 Idenix Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
EP2970357B1 (en) 2013-03-13 2025-01-01 Idenix Pharmaceuticals LLC Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (en) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoro nucleosides for the treatment of hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
EP3027636B1 (en) 2013-08-01 2022-01-05 Idenix Pharmaceuticals LLC D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
SG10201801956SA (en) 2013-09-09 2018-04-27 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
EP3038623A4 (en) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
BR112017019349A2 (pt) 2015-03-11 2018-06-05 Melinta Therapeutics Inc compostos antimicrobianos e métodos de fabricação e uso dos mesmos
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
US20220396830A1 (en) * 2021-05-13 2022-12-15 Promega Corporation Bioluminescent detection of dna synthesis
WO2024044375A2 (en) * 2022-08-26 2024-02-29 Regents Of The University Of Minnesota Antiviral compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62255499A (ja) 1986-04-28 1987-11-07 Teijin Ltd 螢光性ヌクレオシド又はヌクレオチド
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
GB9109186D0 (en) * 1991-04-29 1991-06-19 Wellcome Found Preparation of thionucleosides
YU43193A (sh) 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
JPH06192285A (ja) * 1992-12-25 1994-07-12 Yamasa Shoyu Co Ltd １−（β−Ｄ−エリスロ−ペントフラン−２−ウロシル）ピリミジン誘導体の製造法
DE4321978A1 (de) * 1993-07-01 1995-01-12 Boehringer Mannheim Gmbh Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
GB9505025D0 (en) 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) * 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues
WO2001007454A1 (en) * 1999-07-22 2001-02-01 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
IL147749A0 (en) * 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors
EP1202749A2 (en) * 1999-07-22 2002-05-08 Newbiotics, Inc. Enzyme catalyzed anti-infective therapeutic agents

Also Published As

Publication number Publication date
WO1998049177A8 (en) 2000-01-13
DE69806919T2 (de) 2003-02-27
EP0980377A1 (en) 2000-02-23
CA2288147A1 (en) 1998-11-05
CA2288147C (en) 2008-03-11
AU737902B2 (en) 2001-09-06
JP2001522369A (ja) 2001-11-13
PT980377E (pt) 2002-12-31
JP4514242B2 (ja) 2010-07-28
ES2181208T3 (es) 2003-02-16
EP0980377B1 (en) 2002-07-31
ATE221543T1 (de) 2002-08-15
DE69806919D1 (de) 2002-09-05
WO1998049177A1 (en) 1998-11-05
DK0980377T3 (da) 2002-11-18
AU7219398A (en) 1998-11-24
NZ500881A (en) 2001-11-30
US6573247B1 (en) 2003-06-03

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