GB9616305D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
GB9616305D0
GB9616305D0 GBGB9616305.0A GB9616305A GB9616305D0 GB 9616305 D0 GB9616305 D0 GB 9616305D0 GB 9616305 A GB9616305 A GB 9616305A GB 9616305 D0 GB9616305 D0 GB 9616305D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9616305.0A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to GBGB9616305.0A priority Critical patent/GB9616305D0/en
Publication of GB9616305D0 publication Critical patent/GB9616305D0/en
Priority to CA002240467A priority patent/CA2240467A1/en
Priority to NZ325837A priority patent/NZ325837A/xx
Priority to DE69629721T priority patent/DE69629721T2/de
Priority to JP52482697A priority patent/JP4163254B2/ja
Priority to PL96327737A priority patent/PL327737A1/xx
Priority to EP96944684A priority patent/EP0874809B1/en
Priority to KR1019980705118A priority patent/KR19990076988A/ko
Priority to SK910-98A priority patent/SK91098A3/sk
Priority to HU0001741A priority patent/HUP0001741A3/hu
Priority to PCT/EP1996/005874 priority patent/WO1997025309A1/en
Priority to ES96944684T priority patent/ES2205072T3/es
Priority to TR1998/01282T priority patent/TR199801282T2/xx
Priority to AT96944684T priority patent/ATE248143T1/de
Priority to EA199800525A priority patent/EA199800525A1/ru
Priority to IL12491296A priority patent/IL124912A0/xx
Priority to APAP/P/1998/001283A priority patent/AP9801283A0/en
Priority to CN96180177A priority patent/CN1214039A/zh
Priority to US09/101,210 priority patent/US6020368A/en
Priority to BR9612426A priority patent/BR9612426A/pt
Priority to AU13078/97A priority patent/AU715229B2/en
Priority to HU9900973A priority patent/HUP9900973A3/hu
Priority to CZ982124A priority patent/CZ212498A3/cs
Priority to ARP970100026A priority patent/AR005357A1/es
Priority to MA24698A priority patent/MA24348A1/fr
Priority to UY24603A priority patent/UY24603A1/es
Priority to IDP972319A priority patent/ID19442A/id
Priority to PE1997000574A priority patent/PE87698A1/es
Priority to APAP/P/1997/001040A priority patent/AP9701040A0/en
Priority to APAP/P/1997/001047A priority patent/AP872A/en
Priority to ES97940050T priority patent/ES2182114T3/es
Priority to CZ99293A priority patent/CZ29399A3/cs
Priority to US09/230,715 priority patent/US6121281A/en
Priority to DE69716455T priority patent/DE69716455T2/de
Priority to NZ333926A priority patent/NZ333926A/xx
Priority to BR9711008A priority patent/BR9711008A/pt
Priority to AT97940050T priority patent/ATE226203T1/de
Priority to PL97331470A priority patent/PL331470A1/xx
Priority to CN97198347A priority patent/CN1231665A/zh
Priority to EP97940050A priority patent/EP0934316B1/en
Priority to JP50758498A priority patent/JP4204069B2/ja
Priority to IL12831997A priority patent/IL128319A0/xx
Priority to PCT/EP1997/004166 priority patent/WO1998005659A1/en
Priority to CA002262460A priority patent/CA2262460A1/en
Priority to KR1019997000856A priority patent/KR20000029748A/ko
Priority to TR1999/00194T priority patent/TR199900194T2/xx
Priority to AU42036/97A priority patent/AU4203697A/en
Priority to PE1997000668A priority patent/PE99098A1/es
Priority to IDP972673A priority patent/ID17421A/id
Priority to UY24653A priority patent/UY24653A1/es
Priority to MA24748A priority patent/MA24355A1/fr
Priority to ZA976817A priority patent/ZA976817B/xx
Priority to CO97044307A priority patent/CO5031248A1/es
Priority to ARP970103499A priority patent/AR010984A1/es
Priority to MX9805416A priority patent/MX9805416A/es
Priority to NO983074A priority patent/NO983074L/no
Priority to OA9800101A priority patent/OA10708A/en
Priority to BG102600A priority patent/BG102600A/xx
Priority to NO990463A priority patent/NO990463L/no
Priority to US09/467,695 priority patent/US6239175B1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
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    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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    • C07C2601/14—The ring being saturated
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

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GBGB9616305.0A 1996-01-03 1996-08-02 Novel compounds Pending GB9616305D0 (en)

Priority Applications (60)

Application Number Priority Date Filing Date Title
GBGB9616305.0A GB9616305D0 (en) 1996-08-02 1996-08-02 Novel compounds
CA002240467A CA2240467A1 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
NZ325837A NZ325837A (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
DE69629721T DE69629721T2 (de) 1996-01-03 1996-12-19 Carnamoyloxy derivate von mutilin und deren verwendung als antibakterielles mittels
JP52482697A JP4163254B2 (ja) 1996-01-03 1996-12-19 ムチリンのカルバモイルオキシ誘導体および抗細菌剤としてのそれらの使用
PL96327737A PL327737A1 (en) 1996-01-03 1996-12-19 Carbamoyloxylic derivatives of mutiline and their application as bactericides
EP96944684A EP0874809B1 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
KR1019980705118A KR19990076988A (ko) 1996-01-03 1996-12-19 머틸린의 카르바모일옥시 유도체 및 항균제로서의 이들의 용도
SK910-98A SK91098A3 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
HU0001741A HUP0001741A3 (en) 1996-08-02 1996-12-19 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
PCT/EP1996/005874 WO1997025309A1 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
ES96944684T ES2205072T3 (es) 1996-01-03 1996-12-19 Derivados carbamoiloxi de mutilina y su uso como agentes antibacterianos.
TR1998/01282T TR199801282T2 (xx) 1996-01-03 1996-12-19 Mutilin'in karbamoiloksi t�revleri ve antibakteriyel olarak kullan�m�.
AT96944684T ATE248143T1 (de) 1996-01-03 1996-12-19 Carnamoyloxy derivate von mutilin und deren verwendung als antibakterielles mittels
EA199800525A EA199800525A1 (ru) 1996-01-03 1996-12-19 Карбамоилоксипроизводные мутилина и их применение в качестве антибактериальных средств
IL12491296A IL124912A0 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
APAP/P/1998/001283A AP9801283A0 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials.
CN96180177A CN1214039A (zh) 1996-01-03 1996-12-19 姆替林的氨基甲酰氧基衍生物及其抗菌素用途
US09/101,210 US6020368A (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
BR9612426A BR9612426A (pt) 1996-01-03 1996-12-19 Derivados carbomoilóxi e sua aplicação como antibacterianos
AU13078/97A AU715229B2 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline and their use as antibacterials
HU9900973A HUP9900973A3 (en) 1996-01-03 1996-12-19 Carbamoyloxy derivatives of mutiline with antibacterial activity, pharmaceutical compns. contg. them and process for preparing the said compds.
CZ982124A CZ212498A3 (cs) 1996-01-03 1996-12-19 Karbamoyloxyderiváty mutilinu, způsob výroby a farmaceutický prosředek
ARP970100026A AR005357A1 (es) 1996-01-03 1997-01-03 Derivados de 14-o-carbamoil mutilina y sus sales utiles en el tratamiento de infecciones bacterianas, procedimiento para prepararlas, composicionesfarmaceuticas formuladas con dichos derivados y uso de los mismos para preparar dichas composiciones
MA24698A MA24348A1 (fr) 1996-08-02 1997-07-01 Procede de preparation de nouveaux composes
UY24603A UY24603A1 (es) 1996-08-02 1997-07-01 Nuevos compuestos
IDP972319A ID19442A (id) 1996-08-02 1997-07-03 Senyawa terbaru
PE1997000574A PE87698A1 (es) 1996-08-02 1997-07-03 Derivados del 14-o-carbamoilo mutilina
APAP/P/1997/001040A AP9701040A0 (en) 1996-08-02 1997-07-03 Novel compounds.
APAP/P/1997/001047A AP872A (en) 1996-08-02 1997-07-21 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use.
ES97940050T ES2182114T3 (es) 1996-08-02 1997-07-29 Derivados azabiciclicos de la carbamoiloxi-multilina para empleo antibacteriano.
CZ99293A CZ29399A3 (cs) 1996-08-02 1997-07-29 Azabicyklické karbamoyloxymutilinové deriváty
US09/230,715 US6121281A (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
DE69716455T DE69716455T2 (de) 1996-08-02 1997-07-29 Azabicycliache carbamoyloxy mutilin derivate als antibakterielles mittel
NZ333926A NZ333926A (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
BR9711008A BR9711008A (pt) 1996-08-02 1997-07-29 Derivados de multilina de carbamoilÄxi azabicicliocos para uso antibacteriano
AT97940050T ATE226203T1 (de) 1996-08-02 1997-07-29 Azabicycliache carbamoyloxy mutilin derivate als antibakterielles mittel
PL97331470A PL331470A1 (en) 1996-08-02 1997-07-29 Azabicyclocarbamoyloxylic derivatives of mutiline for antibacterial applications
CN97198347A CN1231665A (zh) 1996-08-02 1997-07-29 抗菌用的氮杂双环氨甲酰氧基mutili n衍生物
EP97940050A EP0934316B1 (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
JP50758498A JP4204069B2 (ja) 1996-08-02 1997-07-29 抗細菌用途のアザ二環式カルバモイルオキシムチリン誘導体
IL12831997A IL128319A0 (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
PCT/EP1997/004166 WO1998005659A1 (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
CA002262460A CA2262460A1 (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
KR1019997000856A KR20000029748A (ko) 1996-08-02 1997-07-29 항박테리아용아자비시클릭카르바모일옥시무틸린유도체
TR1999/00194T TR199900194T2 (xx) 1996-08-02 1997-07-29 Antibakteryal kullan�m i�in azabisiklik karbamoiloksi mutilin t�revleri.
AU42036/97A AU4203697A (en) 1996-08-02 1997-07-29 Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
PE1997000668A PE99098A1 (es) 1996-08-02 1997-07-30 Derivados de 14-o-carbamoilo de mutilina
IDP972673A ID17421A (id) 1996-08-02 1997-07-31 Senyawa senyawa baru
UY24653A UY24653A1 (es) 1996-08-02 1997-07-31 Nuevos compuestos
MA24748A MA24355A1 (fr) 1996-08-02 1997-07-31 Procede de preparation de nouveaux composes
ZA976817A ZA976817B (en) 1996-08-02 1997-07-31 Novel compounds
CO97044307A CO5031248A1 (es) 1996-08-02 1997-08-01 Compuesto azabiziclico mutilin 14-carbamatos utiles como an- tibacterianos
ARP970103499A AR010984A1 (es) 1996-08-02 1997-08-01 Nuevos esteres de la pleuromutilina, y el acido 1-azabiciclo-4- carbanilcarbanico; procedimiento para su preparacion y composicionesfarmaceuticas que los contienen.
MX9805416A MX9805416A (es) 1996-01-03 1998-07-02 Derivados de carbamoiloxi de mutilina y su uso como antibacterianos.
NO983074A NO983074L (no) 1996-01-03 1998-07-02 Karbamoyloksyderivater av mutilin og deres anvendelse som antibakterielle midler
OA9800101A OA10708A (en) 1996-01-03 1998-07-02 Carbamoyloxy derivatives of mutiline and their useas antibacterials.
BG102600A BG102600A (en) 1996-01-03 1998-07-03 Carbamoyloxy derivatives of mutilin and their use as bactericides
NO990463A NO990463L (no) 1996-08-02 1999-02-01 Azabicykliske karbamoyloksymutilinderivater for antibakteriell anvendelse
US09/467,695 US6239175B1 (en) 1996-01-03 1999-12-21 Carbamoyloxy derivatives of mutiline and their use as antibacterials

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GBGB9616305.0A GB9616305D0 (en) 1996-08-02 1996-08-02 Novel compounds

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CO (1) CO5031248A1 (id)
GB (1) GB9616305D0 (id)
ID (1) ID19442A (id)
MA (1) MA24348A1 (id)
PE (1) PE87698A1 (id)
UY (1) UY24603A1 (id)
ZA (1) ZA976817B (id)

Also Published As

Publication number Publication date
PE87698A1 (es) 1999-01-30
ZA976817B (en) 1999-02-01
AP9701040A0 (en) 1997-07-31
CO5031248A1 (es) 2001-04-27
ID19442A (id) 1998-07-09
UY24603A1 (es) 1997-12-30
MA24348A1 (fr) 1998-07-01

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