CO5031248A1 - Compuesto azabiziclico mutilin 14-carbamatos utiles como an- tibacterianos - Google Patents

Compuesto azabiziclico mutilin 14-carbamatos utiles como an- tibacterianos

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Publication number
CO5031248A1
CO5031248A1 CO97044307A CO97044307A CO5031248A1 CO 5031248 A1 CO5031248 A1 CO 5031248A1 CO 97044307 A CO97044307 A CO 97044307A CO 97044307 A CO97044307 A CO 97044307A CO 5031248 A1 CO5031248 A1 CO 5031248A1
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Colombia
Prior art keywords
formula
compound
tibacterials
azabiziclico
compuest
Prior art date
Application number
CO97044307A
Other languages
English (en)
Inventor
Andrew Kenneth Takle
Eric Hunt
Antoinette Naylor
Original Assignee
Smithkline Beecham Plc
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Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5031248A1 publication Critical patent/CO5031248A1/es

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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
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    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
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    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
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    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/72—Nitrogen atoms
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Abstract

Un compuesto de fórmula (3), o una de sus sales o derivadosfarmacéuticamente aceptables;en la que :R1 es vinilo o etilo; y R2 es un grupo R3 , R4 CH2 - o R5 R6 C=CH-; en el que cada R3 y R4 es un sistema de anillo azabicíclico o R5 y R6 , junto al átomo de carbono al que se encuentran unidos, forman un sistema de anillo azabacíclico.Un procedimiento para preparar un compuesto según cualquiera de las reivindicaciones anteriores, que incluye hacer reaccionar un compuesto de fórmula (4), en la que X es hidrógeno o un grupo protector de hidroxilo, o un compuesto de fórmula (5), con un isocianato de ácido de fórmula R3 CONCO, R4 CH2 CONCO o R5 R6 C=CHCONCO:Un procedimiento para tratar infecciones microbianas en animales, en especial, en seres humanos y en mamíferos domesticados, que comprende administrar una cantidad eficaz desde el punto de vista antimicrobiano de un compuesto según la reivindicación 1, 2 ó 3, o una composición según la reivindicación 7, a un paciente que lo necesite.
CO97044307A 1996-08-02 1997-08-01 Compuesto azabiziclico mutilin 14-carbamatos utiles como an- tibacterianos CO5031248A1 (es)

Applications Claiming Priority (1)

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GBGB9616305.0A GB9616305D0 (en) 1996-08-02 1996-08-02 Novel compounds

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CO5031248A1 true CO5031248A1 (es) 2001-04-27

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AP (1) AP9701040A0 (es)
CO (1) CO5031248A1 (es)
GB (1) GB9616305D0 (es)
ID (1) ID19442A (es)
MA (1) MA24348A1 (es)
PE (1) PE87698A1 (es)
UY (1) UY24603A1 (es)
ZA (1) ZA976817B (es)

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PE87698A1 (es) 1999-01-30
ZA976817B (en) 1999-02-01
AP9701040A0 (en) 1997-07-31
ID19442A (id) 1998-07-09
UY24603A1 (es) 1997-12-30
GB9616305D0 (en) 1996-09-11
MA24348A1 (fr) 1998-07-01

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