GB954213A - New therapeutically active sulphonamides and process for their preparation - Google Patents
New therapeutically active sulphonamides and process for their preparationInfo
- Publication number
- GB954213A GB954213A GB2785760A GB2785760A GB954213A GB 954213 A GB954213 A GB 954213A GB 2785760 A GB2785760 A GB 2785760A GB 2785760 A GB2785760 A GB 2785760A GB 954213 A GB954213 A GB 954213A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aminobenzenesulphonamido
- thiazole
- methyl
- compounds
- therapeutically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises monoazo compounds of formula <FORM:0954213/C3/1> wherein R1 is a hydrogen atom or an acetyl group, R is a heterocyclic residue containing either a nitrogen atom and a sulphur atom or two nitrogen atoms and A is an aromatic residue which may be substituted. The compounds are therapeutically active. They are prepared by coupling a diazotised aromatic amine with a compound of formula <FORM:0954213/C3/2> The compounds are light yellow in colour. In examples the preparation of the following compounds is described: 2-(p-aminobenzenesulphonamido) - 4 - methyl - 5 - (p - chlorophenylazo) - thiazole; 2 - (p - aminobenzenesulphonamido) - 4 - methyl - 5 - (phenylazo)-thiazole; 2 - (p - aminobenzenesulphonamido)- 4 - methyl - 5 - (p - tolylazo) - thiazole; 2 - (p-acetylaminobenzenesulphonamido) - 4 - methyl- 5 - (p - chlorophenylazo) - thiazole; 2 - (p - aminobenzenesulphonamido) - 4,6 - dimethyl- 5 - (phenylazo) - pyrimidine; 2 - (p - aminobenzenesulphonamido) - 4 - methyl - 5 - (p-ethoxyphenylazo) - thiazole; 2 - (p - aminobenzenesulphonamido) - 4 - methyl - 5 - (l-naphthylazo) - thiazole; 2 - (p - aminobenzenesulphonamido) - 5 - (p - chlorophenylazo) - thiazole and 2 - (p - aminobenzenesulphonamido)-4-phenyl-5-(p-tolylazo)-thiazole. Compounds of the above formula are therapeutically active and may be used in pharmaceutical compositions. Specified compositions are wound sprayings, ointments for eyes or wounds, aqueous suspensions, aerosols and enterosolvent dragees. The compounds are effective against strepto-, staphylo- and pneumo-cocci and have some action on strains of Staphylococcus aureus haemolyticus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU30659 | 1959-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB954213A true GB954213A (en) | 1964-04-02 |
Family
ID=10949015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2785760A Expired GB954213A (en) | 1959-08-17 | 1960-08-11 | New therapeutically active sulphonamides and process for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB954213A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406661A (en) | 1980-06-06 | 1983-09-27 | Cassella Aktiengesellschaft | Process for dyeing and printing synthetic, hydrophobic fibre material with dischargeable azo disperse dye |
-
1960
- 1960-08-11 GB GB2785760A patent/GB954213A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406661A (en) | 1980-06-06 | 1983-09-27 | Cassella Aktiengesellschaft | Process for dyeing and printing synthetic, hydrophobic fibre material with dischargeable azo disperse dye |
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