GB935282A - Improvements in and relating to sulphonyl ureas and their manufacture - Google Patents

Improvements in and relating to sulphonyl ureas and their manufacture

Info

Publication number
GB935282A
GB935282A GB2345059A GB2345059A GB935282A GB 935282 A GB935282 A GB 935282A GB 2345059 A GB2345059 A GB 2345059A GB 2345059 A GB2345059 A GB 2345059A GB 935282 A GB935282 A GB 935282A
Authority
GB
United Kingdom
Prior art keywords
tetramethylene
dimethylphenylsulphonyl
salts
ethyl
dimethylbenzenesulphonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2345059A
Inventor
Eric Walton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB2345059A priority Critical patent/GB935282A/en
Priority to ES0259494A priority patent/ES259494A1/en
Publication of GB935282A publication Critical patent/GB935282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises N-3:4-dimethylphenylsulphonyl-N1-tetramethylene urea and salts, such as the sodium salt, thereof, and their preparation by treating pyrrolidine with a reactive carbonic acid derivative of 3:4-dimethylbenzenesulphonamide, such as ethyl 3:4-dimethylbenzenesulphonyl-carbamate, or by reacting 3:4-dimethylbenzenesulphonyl chloride with N-tetramethylene-O-alkylisourea and hydrolysing the resulting N-3:4-dimethylphenylsulphonyl-N1-tetramethylene-O-alkyl isourea with acid. Pharmaceutical preparations for the treatment of diabetes comprise the above compound or a salt thereof together with a pharmaceutical carrier. The Provisional Specification comprises N-phenylsulphonyl-N1-tetramethylene-ureas and salts thereof which carry methyl, ethyl, n-propyl, isopropyl, methoxy, ethoxy or bromine substituents in the 3- and 4-positions of the benzene ring.
GB2345059A 1959-07-08 1959-07-08 Improvements in and relating to sulphonyl ureas and their manufacture Expired GB935282A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB2345059A GB935282A (en) 1959-07-08 1959-07-08 Improvements in and relating to sulphonyl ureas and their manufacture
ES0259494A ES259494A1 (en) 1959-07-08 1960-07-07 Improvements in and relating to sulphonyl ureas and their manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2345059A GB935282A (en) 1959-07-08 1959-07-08 Improvements in and relating to sulphonyl ureas and their manufacture

Publications (1)

Publication Number Publication Date
GB935282A true GB935282A (en) 1963-08-28

Family

ID=10195830

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2345059A Expired GB935282A (en) 1959-07-08 1959-07-08 Improvements in and relating to sulphonyl ureas and their manufacture

Country Status (2)

Country Link
ES (1) ES259494A1 (en)
GB (1) GB935282A (en)

Also Published As

Publication number Publication date
ES259494A1 (en) 1961-01-01

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