GB945671A - 2-sulphamoylthiazoles and a process for their preparation - Google Patents

2-sulphamoylthiazoles and a process for their preparation

Info

Publication number
GB945671A
GB945671A GB11581/60A GB1158160A GB945671A GB 945671 A GB945671 A GB 945671A GB 11581/60 A GB11581/60 A GB 11581/60A GB 1158160 A GB1158160 A GB 1158160A GB 945671 A GB945671 A GB 945671A
Authority
GB
United Kingdom
Prior art keywords
chloride
carbo
alkoxy
carboxyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11581/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB945671A publication Critical patent/GB945671A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention comprises compounds of the formula: <FORM:0945671/C2/1> wherein X is hydrogen, carboxyl, carbo (C1-5 alkoxy) or chlorine, Y is methyl, carboxyl, carbo (C1-5 alkoxy), phenyl, p-carboxyphenyl or p-carbo (C1-5 alkoxy) phenyl including alkalimetal salts of these compounds, and their preparation by chlorinating the appropriate 2-mercapto-substituted-thiazole (obtained for example by reacting a ketone of the formula Y.CO.CHX.Halogen with ammonium dithiocarbonate) and reacting the resulting sulphonyl chloride with ammonia. Products wherein X or Y contain a carboxyl group are conveniently prepared via the corresponding esters. p-Carbethoxphenacetyl chloride used as a starting material is made by treating p-cyanophenacetyl chloride with ethanol and dry hydrogen chloride. Pharmaceutical preparations having diuretic activity comprise the above compounds of the invention in a suitable form for administration such as a tablet for oral use or a solution in an isotonic aqueous medium for injection.
GB11581/60A 1959-04-06 1960-04-01 2-sulphamoylthiazoles and a process for their preparation Expired GB945671A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80413459A 1959-04-06 1959-04-06

Publications (1)

Publication Number Publication Date
GB945671A true GB945671A (en) 1964-01-08

Family

ID=25188264

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11581/60A Expired GB945671A (en) 1959-04-06 1960-04-01 2-sulphamoylthiazoles and a process for their preparation

Country Status (1)

Country Link
GB (1) GB945671A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029904A1 (en) * 1994-04-29 1995-11-09 Allergan Substituted thiazole sulfonamides as antiglaucoma agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029904A1 (en) * 1994-04-29 1995-11-09 Allergan Substituted thiazole sulfonamides as antiglaucoma agents

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