GB924421A - Aminosteroid compounds and process for their manufacture - Google Patents
Aminosteroid compounds and process for their manufactureInfo
- Publication number
- GB924421A GB924421A GB27165/59A GB2716559A GB924421A GB 924421 A GB924421 A GB 924421A GB 27165/59 A GB27165/59 A GB 27165/59A GB 2716559 A GB2716559 A GB 2716559A GB 924421 A GB924421 A GB 924421A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- steroid
- pharmaceutical preparations
- manufacture
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NDDAQHROMJDMKS-XFYXLWKMSA-N [(2s,3s,5s,8r,9s,10s,13s,14s)-2-hydroxy-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]azanium;chloride Chemical class Cl.C1[C@H](N)[C@@H](O)C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 NDDAQHROMJDMKS-XFYXLWKMSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XIIAYQZJNBULGD-UHFFFAOYSA-N (5alpha)-cholestane Natural products C1CC2CCCCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 XIIAYQZJNBULGD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- XIIAYQZJNBULGD-LDHZKLTISA-N cholestane Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 XIIAYQZJNBULGD-LDHZKLTISA-N 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 150000003128 pregnanes Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- INLFWQCRAJUDCR-LYLBMTSKSA-N spirostane Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CCCCC4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 INLFWQCRAJUDCR-LYLBMTSKSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001549 tubercolostatic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6266958A CH368163A (de) | 1958-08-07 | 1958-08-07 | Verfahren zur Herstellung von Amino-steroiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB924421A true GB924421A (en) | 1963-04-24 |
Family
ID=4524441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27165/59A Expired GB924421A (en) | 1958-08-07 | 1959-08-07 | Aminosteroid compounds and process for their manufacture |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3004968A (cg-RX-API-DMAC7.html) |
| CH (1) | CH368163A (cg-RX-API-DMAC7.html) |
| DE (1) | DE1131665B (cg-RX-API-DMAC7.html) |
| GB (1) | GB924421A (cg-RX-API-DMAC7.html) |
| NL (2) | NL242068A (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197296A (en) * | 1977-03-23 | 1980-04-08 | Glaxo Group Limited | Androstanes |
| US4352798A (en) * | 1980-07-16 | 1982-10-05 | Glaxo Group Limited | 11 α-Amino-androstanes |
| US4353898A (en) * | 1980-07-16 | 1982-10-12 | Glaxo Group Limited | 11α-Amino-androstanes |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3137710A (en) * | 1961-03-30 | 1964-06-16 | Ormonoterapia Richter Spa | Method for the preparation of primary amines |
| US3503959A (en) * | 1962-03-30 | 1970-03-31 | Sterling Drug Inc | 3-amino steroids |
| US3381021A (en) * | 1967-06-02 | 1968-04-30 | Dow Chemical Co | Method for the preparation of alpha, delta-diketones from alpha, beta-ethylenically unsaturated monoketones |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2045574A (en) * | 1936-06-30 | Process for the catalytic | ||
| US2566336A (en) * | 1947-08-28 | 1951-09-04 | Glidden Co | Preparation of keto-amine salts in the steroid series and products |
| US2700682A (en) * | 1948-06-24 | 1955-01-25 | American Home Prod | Ketimines and process of preparing same |
| US2705238A (en) * | 1951-05-19 | 1955-03-29 | Glidden Co | Steroid-dimethylamines and their quaternary halides |
-
0
- NL NL122816D patent/NL122816C/xx active
- NL NL242068D patent/NL242068A/xx unknown
-
1958
- 1958-08-07 CH CH6266958A patent/CH368163A/de unknown
-
1959
- 1959-07-22 US US828709A patent/US3004968A/en not_active Expired - Lifetime
- 1959-07-28 DE DEC19489A patent/DE1131665B/de active Pending
- 1959-08-07 GB GB27165/59A patent/GB924421A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197296A (en) * | 1977-03-23 | 1980-04-08 | Glaxo Group Limited | Androstanes |
| US4352798A (en) * | 1980-07-16 | 1982-10-05 | Glaxo Group Limited | 11 α-Amino-androstanes |
| US4353898A (en) * | 1980-07-16 | 1982-10-12 | Glaxo Group Limited | 11α-Amino-androstanes |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1131665B (de) | 1962-06-20 |
| US3004968A (en) | 1961-10-17 |
| NL122816C (cg-RX-API-DMAC7.html) | |
| CH368163A (de) | 1963-03-31 |
| NL242068A (cg-RX-API-DMAC7.html) |
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