GB9218334D0 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
GB9218334D0
GB9218334D0 GB929218334A GB9218334A GB9218334D0 GB 9218334 D0 GB9218334 D0 GB 9218334D0 GB 929218334 A GB929218334 A GB 929218334A GB 9218334 A GB9218334 A GB 9218334A GB 9218334 D0 GB9218334 D0 GB 9218334D0
Authority
GB
United Kingdom
Prior art keywords
pct
hydroxy
nhch2
sch2
alkylcarbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929218334A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB929218334A priority Critical patent/GB9218334D0/en
Publication of GB9218334D0 publication Critical patent/GB9218334D0/en
Priority to GB939317153A priority patent/GB9317153D0/en
Priority to EP93919477A priority patent/EP0656897B1/en
Priority to CA002143430A priority patent/CA2143430A1/en
Priority to AU49691/93A priority patent/AU4969193A/en
Priority to AT93919477T priority patent/ATE161843T1/de
Priority to JP6506955A priority patent/JPH08502731A/ja
Priority to ZA936201A priority patent/ZA936201B/xx
Priority to DE69316224T priority patent/DE69316224D1/de
Priority to PCT/GB1993/001802 priority patent/WO1994005660A1/en
Priority to IL106797A priority patent/IL106797A0/xx
Priority to US08/392,928 priority patent/US5714496A/en
Priority to MX9305200A priority patent/MX9305200A/es
Priority to CA002104981A priority patent/CA2104981A1/en
Priority to TW082107086A priority patent/TW231293B/zh
Priority to FI950893A priority patent/FI950893A0/fi
Priority to NO950756A priority patent/NO950756L/no
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB929218334A 1992-08-28 1992-08-28 Heterocyclic compounds Pending GB9218334D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
GB939317153A GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds
CA002143430A CA2143430A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
DE69316224T DE69316224D1 (de) 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren
PCT/GB1993/001802 WO1994005660A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
AU49691/93A AU4969193A (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
AT93919477T ATE161843T1 (de) 1992-08-28 1993-08-24 Chinuclidine derivate als squalen synthase inhibitoren
JP6506955A JPH08502731A (ja) 1992-08-28 1993-08-24 スクアレンシンターゼ阻害剤としてのキヌクリジン誘導体
ZA936201A ZA936201B (en) 1992-08-28 1993-08-24 Heterocyclic compounds
EP93919477A EP0656897B1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors
IL106797A IL106797A0 (en) 1992-08-28 1993-08-25 Heterocyclic compounds
US08/392,928 US5714496A (en) 1992-08-28 1993-08-25 Quinuclidine derivatives as squalene synthase inhibitors
MX9305200A MX9305200A (es) 1992-08-28 1993-08-27 Compuestos heterociclicos
CA002104981A CA2104981A1 (en) 1992-08-28 1993-08-27 Heterocyclic compounds
TW082107086A TW231293B (enExample) 1992-08-28 1993-08-31
FI950893A FI950893A0 (fi) 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina
NO950756A NO950756L (no) 1992-08-28 1995-02-27 Kinuklidinderivater som squalensyntetase-inhibitorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB9218334D0 true GB9218334D0 (en) 1992-10-14

Family

ID=10721113

Family Applications (2)

Application Number Title Priority Date Filing Date
GB929218334A Pending GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
GB939317153A Pending GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB939317153A Pending GB9317153D0 (en) 1992-08-28 1993-08-18 Heterocyclic compounds

Country Status (13)

Country Link
US (1) US5714496A (enExample)
EP (1) EP0656897B1 (enExample)
JP (1) JPH08502731A (enExample)
AT (1) ATE161843T1 (enExample)
AU (1) AU4969193A (enExample)
CA (2) CA2143430A1 (enExample)
DE (1) DE69316224D1 (enExample)
FI (1) FI950893A0 (enExample)
GB (2) GB9218334D0 (enExample)
IL (1) IL106797A0 (enExample)
TW (1) TW231293B (enExample)
WO (1) WO1994005660A1 (enExample)
ZA (1) ZA936201B (enExample)

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US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
DE122006000066I2 (de) * 1991-05-31 2007-12-06 Pfizer Chinuclidinderivate
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
DE4417837A1 (de) * 1994-05-20 1995-11-23 Basf Ag Substituierte 3-Phenylpyrazole
GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
AU7871498A (en) * 1996-12-20 1998-07-17 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
EP1217001B1 (en) * 1999-09-28 2005-12-07 Eisai Co., Ltd. Quinuclidine compounds and drugs containing the same as the active ingredient
JP2004506686A (ja) * 2000-08-21 2004-03-04 ジョージタウン　ユニバーシティ モノアミン輸送体のモジュレーターとしての２，３−二置換キヌクリジン、及びこれに基づく治療及び診断法
US7112593B2 (en) 2001-03-27 2006-09-26 Eisai Co., Ltd. N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
JP2005512974A (ja) * 2001-10-17 2005-05-12 ユ セ ベ ソシエテ アノニム キヌクリジン誘導体、その調製方法、及びｍ２及び／又はｍ３ムスカリン受容体阻害剤としてのその使用
GB0127731D0 (en) * 2001-11-20 2002-01-09 Coin Controls Coin handling apparatus
CA2480378A1 (en) * 2002-05-07 2003-11-20 Neurosearch A/S Novel azacyclic ethynyl derivatives
PT1988397E (pt) 2002-12-19 2011-12-02 Scripps Research Inst Composições e utilizações para estabilização da transtirretina e inibição do enrolamento
CN103724343A (zh) 2004-03-25 2014-04-16 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
WO2005113523A1 (en) 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EA200700243A1 (ru) * 2004-07-14 2007-08-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения гепатита с
CA2578636A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
CA2584485C (en) 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
CN101365446B (zh) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
JP5635535B2 (ja) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション 心血管疾患の予防および治療のための化合物
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
CN107252429B (zh) 2009-04-22 2023-06-16 雷斯韦洛吉克斯公司 新抗炎剂
JP5869677B2 (ja) 2011-09-16 2016-02-24 ファイザー・インク トランスサイレチン解離阻害剤の固体形態
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

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NL6715600A (enExample) * 1966-12-02 1968-06-04
US3534053A (en) * 1967-05-24 1970-10-13 American Home Prod Quinuclidine derivatives
US3763168A (en) * 1968-09-09 1973-10-02 Sterling Drug Inc N-(3-quinuclidinyl) acylanilides
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3725410A (en) * 1970-07-15 1973-04-03 American Home Prod 3-aminomethyl-3-quinuclidinols
US3679690A (en) * 1971-03-18 1972-07-25 Sterling Drug Inc Certain n-(pyridyl) propionanilides
FR2183565B1 (enExample) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
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Also Published As

Publication number Publication date
US5714496A (en) 1998-02-03
IL106797A0 (en) 1993-12-08
CA2104981A1 (en) 1994-03-01
JPH08502731A (ja) 1996-03-26
ATE161843T1 (de) 1998-01-15
EP0656897B1 (en) 1998-01-07
FI950893A7 (fi) 1995-02-27
FI950893A0 (fi) 1995-02-27
WO1994005660A1 (en) 1994-03-17
EP0656897A1 (en) 1995-06-14
GB9317153D0 (en) 1993-10-06
CA2143430A1 (en) 1994-03-17
DE69316224D1 (de) 1998-02-12
AU4969193A (en) 1994-03-29
TW231293B (enExample) 1994-10-01
ZA936201B (en) 1994-02-28

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Legal Events

Date Code Title Description
730A Proceeding under section 30 patents act 1977