GB916709A - Improvements in or relating to the formation of reagents useful in steroid synthesisand the reagents thus produced - Google Patents

Improvements in or relating to the formation of reagents useful in steroid synthesisand the reagents thus produced

Info

Publication number
GB916709A
GB916709A GB3692860A GB3692860A GB916709A GB 916709 A GB916709 A GB 916709A GB 3692860 A GB3692860 A GB 3692860A GB 3692860 A GB3692860 A GB 3692860A GB 916709 A GB916709 A GB 916709A
Authority
GB
United Kingdom
Prior art keywords
reagents
steroid
synthesisand
relating
formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3692860A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB916709A publication Critical patent/GB916709A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises an improvement in or modification of the process for the preparation of 5a -hydroxy-6b -fluoro or 9a -fluoro-11b -hydroxy steroid compounds claimed in the parent Specification which comprises first introducing anhydrous HF into dimethylformamide at an elevated temperature, cooling the reagent thus formed to below 10 DEG C. and then reacting it with a 5a ,6a -epoxy or 9b ,11b -epoxy steroid so as thus to form the desired 5a -hydroxy-6b -fluoro or 9a -fluoro-11b -hydroxy steroid compound, and a process for the preparation of the reagent claimed in the parent Specification by introducing anhydrous HF into dimethylformamide at elevated temperature, e.g. 40 DEG -60 DEG C.
GB3692860A 1959-11-13 1960-10-27 Improvements in or relating to the formation of reagents useful in steroid synthesisand the reagents thus produced Expired GB916709A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR810032A FR77254E (en) 1959-11-13 1959-11-13 Process for the preparation of fluoro-hydroxy steroids

Publications (1)

Publication Number Publication Date
GB916709A true GB916709A (en) 1963-01-23

Family

ID=8721229

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3692860A Expired GB916709A (en) 1959-11-13 1960-10-27 Improvements in or relating to the formation of reagents useful in steroid synthesisand the reagents thus produced

Country Status (5)

Country Link
BE (1) BE596977R (en)
CH (1) CH395977A (en)
ES (1) ES262186A2 (en)
FR (1) FR77254E (en)
GB (1) GB916709A (en)

Also Published As

Publication number Publication date
ES262186A2 (en) 1960-12-16
FR77254E (en) 1962-02-09
CH395977A (en) 1965-07-31
BE596977R (en) 1961-05-10

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