GB905100A - Preparation of new morphine derivatives - Google Patents
Preparation of new morphine derivativesInfo
- Publication number
- GB905100A GB905100A GB1156/61A GB115661A GB905100A GB 905100 A GB905100 A GB 905100A GB 1156/61 A GB1156/61 A GB 1156/61A GB 115661 A GB115661 A GB 115661A GB 905100 A GB905100 A GB 905100A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydroxy
- preparation
- methoxymethyl
- och2och3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- VFNHLTBRAFJQER-ISWURRPUSA-N (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-methyl-2,4,7a,13-tetrahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)C=C[C@@]3(O)[C@]4([H])N(C)CC[C@]13C1=C2C(O)=CC=C1C4 VFNHLTBRAFJQER-ISWURRPUSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- XJUZRXYOEPSWMB-UHFFFAOYSA-N Chloromethyl methyl ether Chemical compound COCCl XJUZRXYOEPSWMB-UHFFFAOYSA-N 0.000 abstract 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940061627 chloromethyl methyl ether Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- XYDYWTJEGDZLTH-UHFFFAOYSA-N methylenetriphenylphosphorane Chemical group C=1C=CC=CC=1P(C=1C=CC=CC=1)(=C)C1=CC=CC=C1 XYDYWTJEGDZLTH-UHFFFAOYSA-N 0.000 abstract 1
- PFBSOANQDDTNGJ-YNHQPCIGSA-N morphinone Chemical class O([C@H]1C(C=C[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O PFBSOANQDDTNGJ-YNHQPCIGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US212160A | 1960-01-13 | 1960-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB905100A true GB905100A (en) | 1962-09-05 |
Family
ID=21699322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1156/61A Expired GB905100A (en) | 1960-01-13 | 1961-01-11 | Preparation of new morphine derivatives |
Country Status (3)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0039066A3 (en) * | 1980-04-28 | 1981-11-18 | E.I. Du Pont De Nemours And Company | 17-substituted 6-desoxy-7,8-dihydro-6-alpha-methylnoroxymorphone narcotic antagonists |
-
1961
- 1961-01-11 FR FR849453A patent/FR848M/fr active Active
- 1961-01-11 GB GB1156/61A patent/GB905100A/en not_active Expired
- 1961-01-12 BE BE599031A patent/BE599031A/fr unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0039066A3 (en) * | 1980-04-28 | 1981-11-18 | E.I. Du Pont De Nemours And Company | 17-substituted 6-desoxy-7,8-dihydro-6-alpha-methylnoroxymorphone narcotic antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| BE599031A (fr) | 1961-07-12 |
| FR848M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1961-10-02 |
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