GB1012492A - Improvements in or relating to 6-alkylmorphinan derivatives and their preparation - Google Patents
Improvements in or relating to 6-alkylmorphinan derivatives and their preparationInfo
- Publication number
- GB1012492A GB1012492A GB13485/63A GB1348563A GB1012492A GB 1012492 A GB1012492 A GB 1012492A GB 13485/63 A GB13485/63 A GB 13485/63A GB 1348563 A GB1348563 A GB 1348563A GB 1012492 A GB1012492 A GB 1012492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparation
- general formula
- hydrogen atom
- alkylmorphinan
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:1012492/C2/1> where R represents a hydrogen atom or a methyl group; R1 represents an alkyl group having not more than five carbon atoms and X represents a hydrogen atom or a hydroxyl group, and the preparation thereof by the catalystic hydrogenation of compounds of the general formula <FORM:1012492/C2/2> where a double bond exists between the 6-position and an adjacent position thereto. As catalysts there may be used platinum, palladium or nickel catalysts, for example in an inert solvent medium. The reaction is generally carried out at between 15 DEG C. and 30 DEG C. under atmospheric pressure. The 6-alkylmorphinans form acid addition salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1425262 | 1962-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1012492A true GB1012492A (en) | 1965-12-08 |
Family
ID=11855883
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13485/63A Expired GB1012492A (en) | 1962-04-09 | 1963-04-04 | Improvements in or relating to 6-alkylmorphinan derivatives and their preparation |
GB13483/63A Expired GB1031366A (en) | 1962-04-09 | 1963-04-04 | Improvements in or relating to the hydrogenation of morphinan derivatives and the products thereof |
GB13477/63A Expired GB1031363A (en) | 1962-04-09 | 1963-04-04 | Improvements in or relating to the hydrogenation of unsaturated morphinans and the products thereof |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13483/63A Expired GB1031366A (en) | 1962-04-09 | 1963-04-04 | Improvements in or relating to the hydrogenation of morphinan derivatives and the products thereof |
GB13477/63A Expired GB1031363A (en) | 1962-04-09 | 1963-04-04 | Improvements in or relating to the hydrogenation of unsaturated morphinans and the products thereof |
Country Status (2)
Country | Link |
---|---|
CH (3) | CH450443A (en) |
GB (3) | GB1012492A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4322426A (en) * | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
-
1963
- 1963-04-04 GB GB13485/63A patent/GB1012492A/en not_active Expired
- 1963-04-04 GB GB13483/63A patent/GB1031366A/en not_active Expired
- 1963-04-04 GB GB13477/63A patent/GB1031363A/en not_active Expired
- 1963-04-08 CH CH448163A patent/CH450443A/en unknown
- 1963-04-08 CH CH447963A patent/CH433361A/en unknown
- 1963-04-08 CH CH448063A patent/CH433362A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4322426A (en) * | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
Also Published As
Publication number | Publication date |
---|---|
CH433361A (en) | 1967-04-15 |
GB1031363A (en) | 1966-06-02 |
CH433362A (en) | 1967-04-15 |
CH450443A (en) | 1968-01-31 |
GB1031366A (en) | 1966-06-02 |
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