GB900755A - Improvements in and relating to the production of 2-acylphenothiazines - Google Patents
Improvements in and relating to the production of 2-acylphenothiazinesInfo
- Publication number
- GB900755A GB900755A GB19532/60A GB1953260A GB900755A GB 900755 A GB900755 A GB 900755A GB 19532/60 A GB19532/60 A GB 19532/60A GB 1953260 A GB1953260 A GB 1953260A GB 900755 A GB900755 A GB 900755A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkylene
- reacting
- phenothiazine
- acyl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Abstract
2-Acylphenothiazines of the general formula: <FORM:0900755/IV (b)/1> in which A is an alkylene radical containing 2-5 carbon atoms, R is an alkyl radical containing 1-4 carbon atoms and R1 is an hydroxy substituted alkyl radical containing 1-4 carbon atoms are prepared by reacting a phenothiazine of the general formula: <FORM:0900755/IV (b)/2> either with an alkylene halide or haloalkyl aryl sulphonate and condensing the 2 2-acyl-10-(haloalkyl)-phenothiazine so produced with an N-hydroxyalkyl piperazine, or with piperazine and reacting the 2-acyl-10-(piperazinylalkyl) phenothiazine with an alkylene halohydrin, an alkylene oxide or an alkylene carbonate; or reacting the above 2-acylphenothiazine with either an N-haloalkylpiperazine and reacting the resulting 2-acyl-10-(alkylpiperazinyl)-pheno-thiazine with an alkylene halohydrin, alkylene oxide or alkylene carbonate, or with an N-haloalkyl-N1-hydroxyalkylpiperazine, the condensation involving the 10-position of the 2-acylphenothiazine in each of the aforesaid reactions taking place in the presence of sodium hydride dissolved in dimethyl formamide or dimethyl acetamide. The products may be converted to acid addition salts. Tranquillising compositions comprise the 2-acylphenothiazines or p acid addition salts thereof produced by the process of the invention and an inert carrier. Salts specified include ascorbates and nicotinates. Reference has been directed by the Comptroller to Specification 819,886
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81774059A | 1959-06-03 | 1959-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB900755A true GB900755A (en) | 1962-07-11 |
Family
ID=25223778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19532/60A Expired GB900755A (en) | 1959-06-03 | 1960-06-02 | Improvements in and relating to the production of 2-acylphenothiazines |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE590867A (en) |
| CH (1) | CH402864A (en) |
| ES (1) | ES258570A1 (en) |
| FR (1) | FR235M (en) |
| GB (1) | GB900755A (en) |
-
1960
- 1960-05-16 BE BE590867A patent/BE590867A/en unknown
- 1960-06-02 ES ES0258570A patent/ES258570A1/en not_active Expired
- 1960-06-02 GB GB19532/60A patent/GB900755A/en not_active Expired
- 1960-06-02 CH CH632060A patent/CH402864A/en unknown
- 1960-08-23 FR FR836527A patent/FR235M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BE590867A (en) | 1960-11-16 |
| CH402864A (en) | 1965-11-30 |
| FR235M (en) | 1961-02-27 |
| ES258570A1 (en) | 1960-11-16 |
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