GB897618A - Process for the enzymatic acylation of 6-amino-penicillanic acids - Google Patents
Process for the enzymatic acylation of 6-amino-penicillanic acidsInfo
- Publication number
- GB897618A GB897618A GB3008160A GB3008160A GB897618A GB 897618 A GB897618 A GB 897618A GB 3008160 A GB3008160 A GB 3008160A GB 3008160 A GB3008160 A GB 3008160A GB 897618 A GB897618 A GB 897618A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- penicillanic
- bacteria
- acid
- extracts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 3
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 239000012045 crude solution Substances 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 229960003424 phenylacetic acid Drugs 0.000 abstract 1
- 239000003279 phenylacetic acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
- C07D499/12—Acylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Milling, Drilling, And Turning Of Wood (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF29459A DE1149361B (de) | 1959-09-24 | 1959-09-24 | Verfahren zur Herstellung von 6-Acylaminopenicillansaeuren auf enzymatischem Wege |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB897618A true GB897618A (en) | 1962-05-30 |
Family
ID=7093317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3008160A Expired GB897618A (en) | 1959-09-24 | 1960-08-31 | Process for the enzymatic acylation of 6-amino-penicillanic acids |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE595257A (enrdf_load_stackoverflow) |
| CH (1) | CH388962A (enrdf_load_stackoverflow) |
| DE (1) | DE1149361B (enrdf_load_stackoverflow) |
| DK (1) | DK108723C (enrdf_load_stackoverflow) |
| GB (1) | GB897618A (enrdf_load_stackoverflow) |
| NO (1) | NO115253B (enrdf_load_stackoverflow) |
| SE (1) | SE340282B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596777A (en) * | 1983-08-10 | 1986-06-24 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1745619B1 (de) * | 1963-09-14 | 1969-09-11 | Bayer Ag | Verfahren zur Herstellung von halbsynthetischen 6-Acylaminopenicillansaeuren |
-
1959
- 1959-09-24 DE DEF29459A patent/DE1149361B/de active Pending
-
1960
- 1960-08-24 CH CH957060A patent/CH388962A/de unknown
- 1960-08-31 GB GB3008160A patent/GB897618A/en not_active Expired
- 1960-09-21 DK DK373060A patent/DK108723C/da active
- 1960-09-21 BE BE595257A patent/BE595257A/fr unknown
- 1960-09-23 SE SE911460A patent/SE340282B/xx unknown
- 1960-09-23 NO NO13743660A patent/NO115253B/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596777A (en) * | 1983-08-10 | 1986-06-24 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| SE340282B (enrdf_load_stackoverflow) | 1971-11-15 |
| DE1149361B (de) | 1963-05-30 |
| BE595257A (fr) | 1961-03-21 |
| NO115253B (enrdf_load_stackoverflow) | 1968-09-09 |
| DK108723C (da) | 1968-02-05 |
| CH388962A (de) | 1965-03-15 |
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