GB1292097A - Amino acids - Google Patents

Amino acids

Info

Publication number
GB1292097A
GB1292097A GB2134571A GB2134571A GB1292097A GB 1292097 A GB1292097 A GB 1292097A GB 2134571 A GB2134571 A GB 2134571A GB 2134571 A GB2134571 A GB 2134571A GB 1292097 A GB1292097 A GB 1292097A
Authority
GB
United Kingdom
Prior art keywords
amino acid
insoluble
acylase
water
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2134571A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of GB1292097A publication Critical patent/GB1292097A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1292097 Water-insoluble acylase complexes TANABE SEIYAKU CO Ltd 19 April 1971 [3 Feb 1970] 21345/71 Heading C3H A water-insoluble mould acylase complex of a substantially water-insoluble haloacetyl-polysaccharide has hydrolysing activity such as to hydrolyse an alpha-N-acyl derivative of a racemic amino acid selectively to yield the free L-amino acid. Examples of haloacetyl polysaccharides which may be used are bromoacetylcellulose, bromoacetyl - dextrane, bromoacetylagarose, chloroacetyl - cellulose, chloroacetyldextrane, chloroacetyl - agarose, iodoacetylcellulose, iodoacetyl-dextrane and iodoacetylagarose. Particularly preferred mould acylases are those produced by Aspergillus oryzae or Penicillium vinaceum. The water-insoluble complex may be produced by treating the mould acylase with the water-insoluble haloacetyl polysaccharide in the presence of a protein salting- out agent such as ammonium sulphate. A method of producing a free L-amino acid from a racemic amino acid comprises incubating a solution of an alpha-N-acyl-derivative of the racemic amino acid in the presence of waterinsoluble mould acylase complex to form free L-amino acid in the solution. In a further method of resolution, the solution of the alpha- N-acyl derivative of the racemic amino acid in an aqueous medium is flowed continuously through a column of the acylase preparation and the resulting free L-amino acid and alpha- N-acyl-D-amino acid in the effluent are separated.
GB2134571A 1970-02-03 1971-04-19 Amino acids Expired GB1292097A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP978970 1970-02-03

Publications (1)

Publication Number Publication Date
GB1292097A true GB1292097A (en) 1972-10-11

Family

ID=11729973

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2134571A Expired GB1292097A (en) 1970-02-03 1971-04-19 Amino acids

Country Status (3)

Country Link
DE (1) DE2105009C3 (en)
FR (1) FR2078103A5 (en)
GB (1) GB1292097A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3334848A1 (en) * 1983-09-27 1985-04-04 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING THE OPTICAL ANTIPODES OF TERT.-LEUCIN

Also Published As

Publication number Publication date
DE2105009B2 (en) 1973-04-26
DE2105009C3 (en) 1973-11-15
FR2078103A5 (en) 1971-11-05
DE2105009A1 (en) 1971-09-16

Similar Documents

Publication Publication Date Title
EP0464325A3 (en) Process for the preparation of l-ornithine salts
ES8504247A1 (en) Method for production of an immobilized enzyme preparation by means of a crosslinking agent
GB1257761A (en)
KR860003249A (en) Method for preparing pyoxycamp monohydrate
GB1377243A (en) Process for preparing aromatic hydroxyaldehydes
GB1386500A (en) Microcrystalline cellulose dispersion and method of stabilizing acidic soft drinks therewith
GB1426483A (en) Vincamine derivatives and process for the preparation of vincamine and derivatives thereof
GB1377313A (en) Process for purifying phenylalanine derivatives
GB1292097A (en) Amino acids
GB1419727A (en) Process for the production of lamellar gold powder
GB1303935A (en)
GB1369970A (en) Process for producing 7-aminodesacetoxy-cephalosporanic acid
GB1261363A (en) Acid carboxypeptidase and the preparation thereof
GB1202120A (en) A method of preparing comenic acid
GB1362108A (en) Process for preparing hydroxy-l-proline or n-acetyl-hydroxy- l-proline from hydrolysed gelatin
GB1380555A (en) Process for the preparation of 2,3,5-trimethylhydroquinone
GB1293870A (en) Preparation of cis-1-alkenyl phosphonic acids and their o-carboxyphenyl esters
GB1323017A (en) Production of methacrolein
GB1212551A (en) Penicillins
GB897618A (en) Process for the enzymatic acylation of 6-amino-penicillanic acids
GB1309039A (en) Amplifiying factor of cortisone induction and process for the pro duction thereof
GB1479731A (en) Process for the production of crystals of monosodium glutamate pentahydrate
GB1423273A (en) Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates
GB1387460A (en) Production of 6-aminopenicillanic acid
GB1153275A (en) Production of Alpha, Omega-diaminoalkane Carboxylic Acids

Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees