GB890315A - Improvements in or relating to steroids and the manufacture thereof - Google Patents
Improvements in or relating to steroids and the manufacture thereofInfo
- Publication number
- GB890315A GB890315A GB14248/60A GB1424860A GB890315A GB 890315 A GB890315 A GB 890315A GB 14248/60 A GB14248/60 A GB 14248/60A GB 1424860 A GB1424860 A GB 1424860A GB 890315 A GB890315 A GB 890315A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dione
- chloro
- acetate
- hydroxy
- dihydroxypregnane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 6-chloro-17a -hydroxy-4-pregnene-3,20-dione 17-acetate, the corresponding D 4,6, D 1,4, or D 1,4,6 compounds and a process for the preparation thereof by dehydrating 6b - chloro - 5a , 17a - dihydroxypregnane - 3, 20 - dione 17-acetate and, if desired, subjecting the 6a - chloro - 17a - hydroxy - 4 - pregnene - 3, 20 - dione 17-acetate thus produced to treatment with chloranil and/or 1-dehydrogenation using selenium dioxide. The 6b - chloro - 5a , 17a - dihydroxypregnane-3,20-dione 17-acetate is obtained by treating 5a ,6a -oxido-3b ,17a -dihydroxypregnan-20-one 17-acetate with HCl to obtain the 6b -chloro-5a -hydroxy compound and oxidising this to produce 6b -fluoro-5a ,17a -dihydroxypregnane-3,20-dione. Depending on the acid dehydration agent the 6a - or 6b -isomers are produced. Specification 886,963 is referred to.ALSO:Pharmaceutical compositions comprise 6a -or 6b - chloro - 17a - hydroxy - 4 - pregnene3,20 - dione - 17 - acetate, 6a - chloro - 17a - hydroxy - 1,4 - pregnadiene - 3,20 - dione 17-acetate, 6 - chloro - 17a - hydroxy - 4,6-pregnadiene - 3,20 - dione 17 - acetate or 6-chloro - 17a - hydroxy - 1,4,6 - pregnatriene-3,20 - dione 17 - acetate and a pharmaceutical diluent. They are employed orally as pills, tablets, capsules, solutions, syrups or elixirs, or in liquid forms for injection. Specification 886,963 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US890315XA | 1959-05-19 | 1959-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB890315A true GB890315A (en) | 1962-02-28 |
Family
ID=22215125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB14248/60A Expired GB890315A (en) | 1959-05-19 | 1960-04-22 | Improvements in or relating to steroids and the manufacture thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB890315A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1359154A1 (en) * | 2002-04-29 | 2003-11-05 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Further syntheses of cyproterone acetate |
-
1960
- 1960-04-22 GB GB14248/60A patent/GB890315A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1359154A1 (en) * | 2002-04-29 | 2003-11-05 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Further syntheses of cyproterone acetate |
WO2003092578A2 (en) * | 2002-04-29 | 2003-11-13 | Boehringer Ingelheim International Gmbh | Further syntheses of cyproterone acetate |
WO2003092578A3 (en) * | 2002-04-29 | 2004-04-08 | Boehringer Ingelheim Int | Further syntheses of cyproterone acetate |
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