GB869799A - Improvements in or relating to steroids and the manufacture thereof - Google Patents
Improvements in or relating to steroids and the manufacture thereofInfo
- Publication number
- GB869799A GB869799A GB23895/58A GB2389558A GB869799A GB 869799 A GB869799 A GB 869799A GB 23895/58 A GB23895/58 A GB 23895/58A GB 2389558 A GB2389558 A GB 2389558A GB 869799 A GB869799 A GB 869799A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dione
- dihydroxy
- compound
- dimethyl
- referred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds havingthe formulae: <FORM:0869799/IV (b)/1> <FORM:0869799/IV (b)/2> <FORM:0869799/IV (b)/3> and a process for the preparation thereofwhich comprises treating a compound of the formula: <FORM:0869799/IV (b)/4> with an epoxidising agent to form the corresponding 5,6-oxido compound, alkylating this compound to produce a 5a ,11-dihydroxy-6,11-dialkylallopregnane-3,20-dione-3,20-bis (lower alkylene) ketal, hydrolysing this compound to obtain a 5a ,11-dihydroxy-6,11-dialkylallopregnane-3,20-dione, which may be dehydrated to obtain a 6,11-dialkyl-11-hydroxyprogesterone. Illustrative products of the invention are a 5a , 11b - dihydroxy-6b ,11a - dimethyl-allopregnane-3,20-dione 3,20-bis (lower alkylene) ketal, 5a , 11b - dihydroxy-6b ,11a - dimethyl-allopregnane-3,20-dione, and 6a ,11a -dimethyl-11b -hydroxy-progesterone. Specification 734,805 is referred to.ALSO:A pharmaceutical composition comprises a 6,11 - dialkyl - 11 - hydroxy - progesterone and a pharmaceutical diluent. The compounds may be administered as a stable suspension for injection, or orally in the form of syrups or tablets. Specification 734,805 is referred to. is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US869799XA | 1957-08-09 | 1957-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB869799A true GB869799A (en) | 1961-06-07 |
Family
ID=22202103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB23895/58A Expired GB869799A (en) | 1957-08-09 | 1958-07-24 | Improvements in or relating to steroids and the manufacture thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB869799A (en) |
-
1958
- 1958-07-24 GB GB23895/58A patent/GB869799A/en not_active Expired
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