GB848502A - New isonicotinylhydrazide derivative and process for its preparation - Google Patents

New isonicotinylhydrazide derivative and process for its preparation

Info

Publication number
GB848502A
GB848502A GB175158A GB175158A GB848502A GB 848502 A GB848502 A GB 848502A GB 175158 A GB175158 A GB 175158A GB 175158 A GB175158 A GB 175158A GB 848502 A GB848502 A GB 848502A
Authority
GB
United Kingdom
Prior art keywords
formylbenzal
pyridine
preparation
thiosemicarbazonoformylaniline
carboxyhydrazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB175158A
Inventor
Arthur Adams
Ronald Slack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB175158A priority Critical patent/GB848502A/en
Publication of GB848502A publication Critical patent/GB848502A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides

Abstract

The invention comprises 41-formylbenzal-4-thiosemicarbazonoformylaniline pyridine-4-carboxyhydrazone having the formula: <FORM:0848502/IV(b)/1> and pharmaceutical compositions thereof (see Group VI); and the preparation thereof by condensing41-formylbenzal-4-thiosemicarbazonoformylaniline with pyridine-4-carboxyhydrazide. The product is a therapeutic agent in the treatment of tuberculosis. 41 - Formylbenzal - 4 - thiosemicarbazonoformylaniline is prepared by condensing p-aminobenzaldehyde thiosemicarbazone and terephthal-aldehyde. A by-product, terephthalaldehyde-bispyridine-4-carboxyhydrazone is obtained when, to this reaction mixture, is added pyridine-4-carboxyhydrazide in the preparation of the product of the invention without prior isolation of the above intermediate.ALSO:Pharmaceutical compositions for the treatment of tuberculosis comprise 41-formylbenzal-4-thio-semicarbazoneformylaniline pyridine-4-carboxyhydrazone having the formula: <FORM:0848502/VI/1> and a pharmaceutical diluent. Oral preparations may be in the form of suspensions, syrups, elixirs, emulsions, powders, tablets or capsules. Examples are given of tablets and an aqueous suspension in 65% sucrose solution.
GB175158A 1958-01-17 1958-01-17 New isonicotinylhydrazide derivative and process for its preparation Expired GB848502A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB175158A GB848502A (en) 1958-01-17 1958-01-17 New isonicotinylhydrazide derivative and process for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB175158A GB848502A (en) 1958-01-17 1958-01-17 New isonicotinylhydrazide derivative and process for its preparation

Publications (1)

Publication Number Publication Date
GB848502A true GB848502A (en) 1960-09-21

Family

ID=9727354

Family Applications (1)

Application Number Title Priority Date Filing Date
GB175158A Expired GB848502A (en) 1958-01-17 1958-01-17 New isonicotinylhydrazide derivative and process for its preparation

Country Status (1)

Country Link
GB (1) GB848502A (en)

Similar Documents

Publication Publication Date Title
GB808105A (en) New pharmaceutical compositions
GB848502A (en) New isonicotinylhydrazide derivative and process for its preparation
GB850006A (en) Improvements in or relating to derivatives of nitrofuran
GB1091109A (en) New derivative of phenylbutazone and its preparation
US3131197A (en) 5-(3, 4-carbonyldioxyphenyl)-3-isopropyl-2-oxazolidone
GB842325A (en) Pharmaceutical compositions containing aminoguanidine derivatives
GB1002005A (en) New benzanilide derivatives
GB914524A (en) Thiazole carboxylic acid-(5-nitrofuryl-2-methylidene)-hydrazides and process for their manufacture
GB1046001A (en) Propanolamine derivatives
GB869460A (en) Phenyl-tetrahydropyryl-piperazines
GB874246A (en) Chloral derivative
GB782469A (en) Anti-t.b. factor
GB956252A (en) Improvements in or relating to the production of nitrofurfurylidenehydrazines
GB897693A (en) New substituted 3:3:3-triphenyl-propylamines and process for their manufacture
GB873781A (en) Novel sulphanilamido-pyrimidines and acid addition salts thereof and a process for the manufacture of same
GB986201A (en) Improvements in or relating to nitrofurfurylidene-imidazoles
GB886965A (en) Substituted isonicotinic acid amides and process for their manufacture
GB890829A (en) Novel hydrazones and salts thereof and a process for the manufacture of same
GB860940A (en) New diphenyl derivative
GB869799A (en) Improvements in or relating to steroids and the manufacture thereof
GB933141A (en) Dextromethorphan n-cyclohexylsulphamate
GB884883A (en) Diamino-5,8-quinoline-quinone derivatives
GB830844A (en) Quinoline derivatives and their preparation
GB813778A (en) Quaternary aminoacylphenothiazines
GB858133A (en) Manufacture of metal salts of formo-sulphathiazole