GB888578A - Process for preparing 3:5-diketopyrazolidine derivatives - Google Patents
Process for preparing 3:5-diketopyrazolidine derivativesInfo
- Publication number
- GB888578A GB888578A GB18842/58A GB1884258A GB888578A GB 888578 A GB888578 A GB 888578A GB 18842/58 A GB18842/58 A GB 18842/58A GB 1884258 A GB1884258 A GB 1884258A GB 888578 A GB888578 A GB 888578A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- general formula
- malonic acid
- hydrazine
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
3 : 5-Dioxopyrazolidine derivatives of the general formula p <FORM:0888578/IV (b)/1> (wherein R1 and R2 represent alkyl or aryl groups, or one but not both may represent hydrogen, R3 represents hydrogen or a C1-6 alkyl group, and R4 a C1-6 alkyl group) are manufactured by condensing a mono- or disubstituted malonic acid monoester monohydrazide of the general formula <FORM:0888578/IV (b)/2> (wherein R5 represents an alkoxy group) with a 4-piperidone of the general formula <FORM:0888578/IV (b)/3> reducing the resulting hydrazone, and cyclizing the hydrazide so formed by heating it to about 180 DEG C.-250 DEG C. in the atmosphere of an inert gas or in the presence of an alkali metal alcoholate. Substituted malonic acid ester-monohydrazides of formula II are obtainable by condensing a reactive derivative (e.g. chloride-ester or amideester) of the appropriate substituted malonic acid with hydrazine or with a monoalkylated hydrazine in which the free NH2 group may be protected by a cleavable group. Specifications 843,688, 843,691 and 843,694 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH888578X | 1957-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB888578A true GB888578A (en) | 1962-01-31 |
Family
ID=4545490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB18842/58A Expired GB888578A (en) | 1957-07-12 | 1958-06-12 | Process for preparing 3:5-diketopyrazolidine derivatives |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE569195A (en) |
| CH (1) | CH354786A (en) |
| FR (1) | FR1209245A (en) |
| GB (1) | GB888578A (en) |
-
0
- BE BE569195D patent/BE569195A/xx unknown
-
1957
- 1957-07-12 CH CH354786D patent/CH354786A/en unknown
-
1958
- 1958-06-12 GB GB18842/58A patent/GB888578A/en not_active Expired
- 1958-07-10 FR FR1209245D patent/FR1209245A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH354786A (en) | 1961-06-15 |
| BE569195A (en) | |
| FR1209245A (en) | 1960-02-29 |
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