GB888968A - Improvements in or relating to tetracycline derivatives - Google Patents

Improvements in or relating to tetracycline derivatives

Info

Publication number
GB888968A
GB888968A GB10886/59A GB1088659A GB888968A GB 888968 A GB888968 A GB 888968A GB 10886/59 A GB10886/59 A GB 10886/59A GB 1088659 A GB1088659 A GB 1088659A GB 888968 A GB888968 A GB 888968A
Authority
GB
United Kingdom
Prior art keywords
tetracycline
betahydroxyethyl
diamino
diethylene
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10886/59A
Inventor
Boris Gradnik
Andrea Pedrazzoli
Gianmario Cipelletti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECH S ET D APPLIC SCIENT ET M
Original Assignee
RECH S ET D APPLIC SCIENT ET M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECH S ET D APPLIC SCIENT ET M filed Critical RECH S ET D APPLIC SCIENT ET M
Priority to GB10886/59A priority Critical patent/GB888968A/en
Priority to FR1584701D priority patent/FR1584701A/fr
Priority to BE588705A priority patent/BE588705A/en
Priority to CH301260A priority patent/CH394214A/en
Priority to BR118004/60A priority patent/BR6018004D0/en
Priority to DE1960S0067726 priority patent/DE1129494C2/en
Priority to FR835978A priority patent/FR520M/fr
Publication of GB888968A publication Critical patent/GB888968A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G11/00—Antibiotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to the compound N - [ 41 - ( betahydroxyethyl ) - diethylene - diamino-11-methyl] tetracycline which is very soluble in water and has the formula <FORM:0888968/IV (b)/1> It is prepared by reacting tetracycline base with formaldehyde or paraformaldehyde and N-(betahydroxyethyl)-ethylene diamine in an inert solvent such as methanol, n-butanol, isopropanol or ethyl acetate at 20 DEG C. to 60 DEG C. for 1 to 6 hours and precipitating by the addition of ether. Injectable aqueous solutions of the above tetracycline are used medicinally. Specification 809,585 is referred to.ALSO:An injectable composition comprises an aqueous solution of N-[41-(betahydroxyethyl)-diethylene - diamino - 11 - methyl] - tetracycline of formula <FORM:0888968/VI/1> Specification 809,585 is referred to.
GB10886/59A 1959-03-31 1959-03-31 Improvements in or relating to tetracycline derivatives Expired GB888968A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB10886/59A GB888968A (en) 1959-03-31 1959-03-31 Improvements in or relating to tetracycline derivatives
FR1584701D FR1584701A (en) 1959-03-31 1960-03-15
BE588705A BE588705A (en) 1959-03-31 1960-03-16 Novel derivative of tetracycline and its manufacturing process
CH301260A CH394214A (en) 1959-03-31 1960-03-17 Process for manufacturing a novel derivative of tetracycline
BR118004/60A BR6018004D0 (en) 1959-03-31 1960-03-23 MANUFACTURING PROCESS OF N2 (OU 9, OU7) -4 (BETA HYDROXYETHIL) DIETHYLENYDYAMINO-METHYL TETRACYCLINE
DE1960S0067726 DE1129494C2 (en) 1959-03-31 1960-03-24 PROCESS FOR THE PRODUCTION OF A WATER-SOLUBLE AMINOMETHYLTE TRACYCLINE DERIVATIVE
FR835978A FR520M (en) 1959-03-31 1960-08-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB10886/59A GB888968A (en) 1959-03-31 1959-03-31 Improvements in or relating to tetracycline derivatives

Publications (1)

Publication Number Publication Date
GB888968A true GB888968A (en) 1962-02-07

Family

ID=9976122

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10886/59A Expired GB888968A (en) 1959-03-31 1959-03-31 Improvements in or relating to tetracycline derivatives

Country Status (5)

Country Link
BE (1) BE588705A (en)
BR (1) BR6018004D0 (en)
CH (1) CH394214A (en)
FR (2) FR1584701A (en)
GB (1) GB888968A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1196648B (en) * 1961-03-27 1965-07-15 Leo Ind Chim Farm Spa Process for the preparation of water-soluble derivatives of tetracyclines

Also Published As

Publication number Publication date
CH394214A (en) 1965-06-30
FR1584701A (en) 1970-01-02
BE588705A (en) 1960-07-18
FR520M (en) 1961-05-23
BR6018004D0 (en) 1973-05-24

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