GB886428A - New hydrazide derivatives and processes for their manufacture - Google Patents

New hydrazide derivatives and processes for their manufacture

Info

Publication number
GB886428A
GB886428A GB28540/59A GB2854059A GB886428A GB 886428 A GB886428 A GB 886428A GB 28540/59 A GB28540/59 A GB 28540/59A GB 2854059 A GB2854059 A GB 2854059A GB 886428 A GB886428 A GB 886428A
Authority
GB
United Kingdom
Prior art keywords
formula
reacting
manufacture
processes
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28540/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB886428A publication Critical patent/GB886428A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0886428/IV (b)/1> wherein R1 denotes a hydrogen atom or an alkyl group, R2 a hydrogen atom or an alkyl cycloalkyl, aryl or aralkyl group and R the radical of one of the two epimeric podophyllic acids of the empirical formula C22H23O8 and the preparation thereof by (a) reducing a compound of the general formula <FORM:0886428/IV (b)/2> at the -C=N double bond; (b) reacting a podophyllic acid hydrazide of the formula R.NH.NH2 with an alkylating agent of the formula <FORM:0886428/IV (b)/3> wherein X is a halogen atom or a radical of a sulpho or alkyl sulphuric acid; (c) reacting podophyllotoxin or picropodophyllin with a hydrazine of the formula <FORM:0886428/IV (b)/4> and (d) reacting a hydrazide of the formula R.NH.NH2 with a carbonyl compound of the formula <FORM:0886428/IV (b)/5> with simultaneous reduction of the -C=N double bond. Specification 886,427 is referred to.
GB28540/59A 1958-08-21 1959-08-20 New hydrazide derivatives and processes for their manufacture Expired GB886428A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH886428X 1958-08-21

Publications (1)

Publication Number Publication Date
GB886428A true GB886428A (en) 1962-01-10

Family

ID=4545304

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28540/59A Expired GB886428A (en) 1958-08-21 1959-08-20 New hydrazide derivatives and processes for their manufacture

Country Status (1)

Country Link
GB (1) GB886428A (en)

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